Mass Spectrometry Study of Acylthioureas and Acylthiocarbamates

2002 ◽  
Vol 8 (5) ◽  
pp. 367-374 ◽  
Author(s):  
Roberto Martínez-Alvarez ◽  
Nazario Martín ◽  
Carlos Seoane ◽  
Ana María Plutin ◽  
Margarita Suárez ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electron Impact ◽  
Chemical Ionization ◽  
Impact Ionization ◽  
Fragmentation Process ◽  
Degradation Pathways ◽  
Ion Fragmentation ◽  
Mass Spectrometry Study ◽  
Sequential Product

A variety of acylthiocarbamates and acylthioureas have been investigated under electron impact ionization (EI), chemical ionization (CI) and electrospray ionization (ESI) conditions. Sequential product-ion fragmentation (MSn) was performed to elucidate the degradation pathways for these compounds. Comparisons are made between positive and negative even-electron ions from ESI and CI and the odd-electron ions obtained under EI conditions. The data collected in this paper provide information on the strong differences found in the fragmentation process of these compounds.

Gas-Liquid Chromatographic/Mass Spectrometric Screening Method for T-2 Toxin in Milk

1979 ◽  
Vol 62 (6) ◽  
pp. 1274-1280
Author(s):  
George J Collins ◽  
Joseph D Rosen
Keyword(s):  
Mass Spectrometry ◽  
Electron Impact ◽  
Chemical Ionization ◽  
Impact Ionization ◽  
Trimethylsilyl Ether ◽  
Screening Method ◽  
Internal Standard ◽  
Electron Impact Ionization ◽  
Gas Liquid Chromatography ◽  
Ionization Mass

Abstract A method for the analysis of T-2 toxin in milk is presented. Ethyl acetate extracts of milk samples which had been spiked with T-2 toxin were purified by thin layer chromatography and derivatized with N,O-bis(trimethylsilyl)acetamide to produce the T-2 toxin trimethylsilyl ether (T-2 toxin-TMS). N,O-bis(trimethylsilyl-d9)acetamide was used to make T-2 toxin d9-trimethylsilyl ether (T-2 toxin-d9TMS) which was added to the derivatized milk extract as an internal standard. Samples were analyzed by combined gas-liquid chromatography/mass spectrometry using either electron impact ionization or chemical ionization mass spectrometry. In electron impact ionization analyses, simultaneous monitoring of the T-2 toxin-TMS fragment ion at m/z 436 and the T-2 toxin-d9TMS fragment ion at m/z 445 gave a T-2 toxin-TMS detectability estimated at 6 μg/kg. In chemical ionization analyses, the T-2 toxin-TMS fragment ion at m/z 377 and the T-2 toxin-d9TMS fragment ion at m/z 386 were simultaneously monitored to give a T-2 toxin-TMS detectability estimated at 3 μg/kg. Average recovery was 85% at 200 μg/kg and 65% at 20 μg/kg.

Electron Impact and Chemical Ionization Mass Spectrometry of Some Butyrophenones

1977 ◽  
Vol 60 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Jos G Leferink ◽  
Robert A A Maes
Keyword(s):  
Mass Spectrometry ◽  
Electron Impact ◽  
Mass Spectra ◽  
Chemical Ionization ◽  
Impact Ionization ◽  
Electron Impact Ionization ◽  
Ionization Mass Spectrometry ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass

Abstract The mass spectra of some butyrophenoncs are presented. Electron impact ionization and chemical ionization with isobutane as the reagent gas are compared. The chemical ionization spectra show the quasi molecular ion (M + H)+ to be the most abundant ion. Important fragments in the electron impact spectra are discussed for easy determination of other similar compounds.

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