scholarly journals Possible Role of Potassium Channels in Mu-receptor-Mediated Inhibition and Muscarinic Autoinhibition in Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum

2000 ◽  
Vol 82 (4) ◽  
pp. 343-349 ◽  
Author(s):  
Hideyuki Nishiwaki ◽  
Noriko Saitoh ◽  
Hideaki Nishio ◽  
Tadayoshi Takeuchi ◽  
Fumiaki Hata
1997 ◽  
Vol 74 (2) ◽  
pp. 155-163 ◽  
Author(s):  
Noriko Saitoh ◽  
Ritsuko Fujimoto ◽  
Toshiaki Ishii ◽  
Hideaki Nishio ◽  
Tadayoshi Takeuchi ◽  
...  

1997 ◽  
Vol 74 (2) ◽  
pp. 155-163
Author(s):  
Noriko Saitoh ◽  
Ritsuko Fujimoto ◽  
Toshiaki Ishii ◽  
Hideaki Nishio ◽  
Tadayoshi Takeuchi ◽  
...  

1993 ◽  
Vol 233 (2-3) ◽  
pp. 237-242 ◽  
Author(s):  
Yuko Fukunaga ◽  
Yukiko Mine ◽  
Shiyu Yoshikawa ◽  
Tadayoshi Takeuchi ◽  
Fumiaki Hata ◽  
...  

1984 ◽  
Vol 246 (5) ◽  
pp. G509-G514 ◽  
Author(s):  
D. H. Teitelbaum ◽  
T. M. O'Dorisio ◽  
W. E. Perkins ◽  
T. S. Gaginella

The peptides caerulein, neurotensin, somatostatin, and substance P modulate the activity of intestinal neurons and alter gut motility. We examined the effects of these peptides on acetylcholine release from the myenteric plexus and intestinal contractility in vitro. Caerulein (1 X 10(-9) M), neurotensin (1.5 X 10(-6) M), and substance P (1 X 10(-7) M) significantly enhanced the release of [3H]acetylcholine from the myenteric plexus of the guinea pig ileum. This effect was inhibited by tetrodotoxin (1.6 X 10(-6) M). Somatostatin (10(-6) M) inhibited caerulein- and neurotensin-evoked release of acetylcholine but did not inhibit release induced by substance P. Caerulein, neurotensin, and substance P caused contraction of the guinea pig ileal longitudinal muscle. Somatostatin inhibited the contractions induced by caerulein and neurotensin. In contrast, substance P-induced contraction was not inhibited significantly by somatostatin. Thus, in the guinea pig ileum, caerulein-, neurotensin-, and substance P-induced contractility is due, at least in part, to acetylcholine release from the myenteric plexus. The ability of somatostatin to inhibit peptide-induced contractility is selective, and its mechanism may be attributed to inhibition of acetylcholine release.


2013 ◽  
Vol 25 (2) ◽  
pp. e114-e126 ◽  
Author(s):  
C. Giaroni ◽  
S. Marchet ◽  
E. Carpanese ◽  
V. Prandoni ◽  
R. Oldrini ◽  
...  

1993 ◽  
Vol 239 (1-3) ◽  
pp. 261-264 ◽  
Author(s):  
Shiyu Yoshikawa ◽  
Yuko Fukunaga ◽  
Tadayoshi Takeuchi ◽  
Hideaki Nishio ◽  
Fumiaki Hata

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