scholarly journals The Role of Endothelium-Derived Nitric Oxide in Relaxations to Levcromakalim in the Rat Aorta.

1999 ◽  
Vol 81 (4) ◽  
pp. 362-366 ◽  
Author(s):  
Hiroyuki Kinoshita ◽  
Shizue Iwahashi ◽  
Tetsuya Kakutani ◽  
Kazuhiro Mizumoto ◽  
Hiroshi Iranami ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Aorta

Vasomodulatory effect of novel peroxovanadate compounds on rat aorta: Role of rho kinase and nitric oxide/cGMP pathway

2011 ◽  
Vol 64 (3) ◽  
pp. 274-282 ◽  
Author(s):  
Vivek Khanna ◽  
Manish Jain ◽  
Manoj Kumar Barthwal ◽  
Diganta Kalita ◽  
Jeena Jyoti Boruah ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rho Kinase ◽  
Rat Aorta ◽  
Cgmp Pathway

scholarly journals The Role of Endothelium-Derived Nitric Oxide in Relaxations to Levcromakalim in the Rat Aorta

1999 ◽  
Vol 81 (4) ◽  
pp. 362-366
Author(s):  
Hiroyuki Kinoshita ◽  
Shizue Iwahashi ◽  
Tetsuya Kakutani ◽  
Kazuhiro Mizumoto ◽  
Hiroshi Iranami ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Aorta

scholarly journals Dysfunction in nitric oxide synthesis in streptozotocin treated rat aorta and role of methylglyoxal

2019 ◽  
Vol 842 ◽  
pp. 321-328
Author(s):  
Yousif A. Shamsaldeen ◽  
Mahdi H. Alsugoor ◽  
Lisa A. Lione ◽  
Christopher D. Benham
Keyword(s):  
Nitric Oxide ◽  
Rat Aorta ◽  
Nitric Oxide Synthesis

Relaxant effect of oxime derivatives in isolated rat aorta: role of nitric oxide (NO) formation in smooth muscle

2004 ◽  
Vol 67 (6) ◽  
pp. 1203-1214 ◽  
Author(s):  
Karel Chalupsky ◽  
Irina Lobysheva ◽  
Françoise Nepveu ◽  
Irina Gadea ◽  
Petra Beranova ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Rat Aorta ◽  
Relaxant Effect ◽  
No Formation ◽  
Oxime Derivatives ◽  
Isolated Rat

scholarly journals Role of the Transient Receptor Potential Vanilloid Type 1 (TRPV1) in the Regulation of Nitric Oxide Release in Wistar Rat Aorta

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Elvira Varela-López ◽  
Leonardo del Valle-Mondragón ◽  
Vicente Castrejón-Téllez ◽  
Israel Pérez-Torres ◽  
Araceli Páez Arenas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Transient Receptor Potential ◽  
Rat Aorta ◽  
Aortic Tissue ◽  
Transient Receptor Potential Vanilloid ◽  
Aortic Endothelial Cells ◽  
Aortic Endothelial

The potential transient vanilloid receptor type 1 (TRPV1) plays important functional roles in the vascular system. In the present study, we explored the role of the TRPV1 in the production of nitric oxide (NO), biopterines (BH4 and BH2), cyclic guanosine monophosphate (cGMP), malondialdehyde (MDA), phosphodiesterase-3 (PDE-3), total antioxidant capacity (TAC), and calcitonin gene-related peptide (CGRP) in the rat aorta. Wistar rats were divided into four groups: (1) control, (2) capsaicin (CS, 20 mg/kg), (3) capsazepine (CZ, 24 mg/kg), and (4) CZ + CS. Treatments were applied daily for 4 days before removing the thoracic aortas for testing of aortic tissue and endothelial cells. TRPV1 activation produced increases in BH4 14%, cGMP 25%, NO 29%, and TAC 59.2% in comparison to the controls. BH2 and MDA increased with CZ. CGRP shows a tendency to decrease with CZ. The analysis by immunocytochemistry confirmed that the TRPV1 is present in aortic endothelial cells. Aortic endothelial cells were obtained from healthy rats and cultured to directly explore the effects of CS and CZ. The activation of the TRPV1 (CS 30 μM) produced increases in BH4 17%, NO 36.6%, TAC 56.3%, and CGRP 65%, when compared to controls. BH2 decreased with CZ + CS. CS effects were diminished by CZ in cells and in the tissue. We conclude that the TRPV1 is a structure present in the membrane of aortic endothelial cells and that it participates in the production of NO. The importance of the TRPV1 should be considered in vascular reactivity studies.

scholarly journals Role of nitric oxide and cytoskeleton in regulation of contractile activity smooth muscle cells

2009 ◽  
Vol 8 (3) ◽  
pp. 17-22
Author(s):  
S. V. Gusakova ◽  
M. B. Baskakov ◽  
I. V. Kovalev ◽  
O. S. Melnik ◽  
L. V. Kapilevich ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Sodium Nitroprusside ◽  
Contractile Activity ◽  
Muscle Cells ◽  
Rat Aorta

The influence of modulation of cytoskeleton by colchicine, nocodazole and cytochalasine D on contractile reactions of smooth muscle cells caused by depolarization, phenylephrine end sodium nitroprusside has been investigated by the mechanographical method. It was found that the reduction in smooth muscle cells of rat aorta caused by fenilefrin more sensitive to sodium nitroprusside than the reduction induced hyperpotassium solution. We show that microtubules involved in relaxation, indirect nitric oxide of smooth muscle in hyperpotassium solution, whereas the efficiency of relaxing influence of nitric oxide in rat aorta smooth muscle in the action depends on phenylephrine and microfilaments and microtubules.

Attenuated endothelium-mediated relaxation by acteoside in rat aorta: Role of endothelial [Ca2+]i and nitric oxide/cyclic GMP pathway

Life Sciences ◽  
2004 ◽  
Vol 75 (10) ◽  
pp. 1149-1157 ◽  
Author(s):  
Chi-Wai Lau ◽  
Zhen-Yu Chen ◽  
Chi-Ming Wong ◽  
Xiaoqiang Yao ◽  
Zhendan He ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cyclic Gmp ◽  
Rat Aorta

scholarly journals Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aorta

2017 ◽  
Vol 174 (8) ◽  
pp. 718-733 ◽  
Author(s):  
Chi Ming Wong ◽  
Chak Leung Au ◽  
Suk Ying Tsang ◽  
Chi Wai Lau ◽  
Xiaoqiang Yao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Rat Aorta ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals The role of nitric oxide on the responses of curcumin-treated rat aorta

2012 ◽  
Vol 113 (05) ◽  
pp. 270-273
Author(s):  
E. K. Atalik ◽  
H. Gokbel ◽  
M. Oz ◽  
N. Okudan ◽  
M. Belviranli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Aorta
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