scholarly journals Angiotensin II Type 1-Receptor Antagonist Candesartan Cilexitil Prevents Left Ventricular Dysfunction in Myocardial Infarcted Rats

1998 ◽  
Vol 78 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Hanatani Akihisa ◽  
Yoshiyama Minoru ◽  
Takeuchi Kazuhide ◽  
Kim Shokei ◽  
Nakayama Koji ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular

Comparative effects of tamoxifen and angiotensin II type-1 receptor antagonist therapy on the hemodynamic profile of the ovariectomized female rat

2003 ◽  
Vol 81 (9) ◽  
pp. 915-919 ◽  
Author(s):  
My-Lan Pham-Dang ◽  
Robert Clement ◽  
Isabelle Mercier ◽  
Angelino Calderone
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Body Weight Gain ◽  
Left Ventricular ◽  
Female Rat ◽  
Ovx Rats ◽  
Hemodynamic Profile

Hormonal replacement therapy (HRT) has failed to provide a cardioprotective action in postmenopausal women, and thus alternative pharmacological approaches are required. The present study examined the therapeutic potential of the partial estrogen receptor agonist tamoxifen and the angiotensin II type-1 receptor antagonist irbesartan on the hemodynamic profile of ovariectomized (OVX) female Sprague–Dawley rats (9–11 weeks). Three weeks following ovariectomy, uterine atrophy was evident and body weight was increased as compared with sham-operated animals. Left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), and mean arterial pressure (MAP) were significantly increased in the OVX rats as compared with sham rats. One week following ovariectomy, rats were treated with either tamoxifen (10 mg kg–1 day–1) or irbesartan (40 mg kg–1 day–1) for a period of 2 weeks. The administration of tamoxifen to OVX rats partially reversed uterine atrophy and prevented body weight gain, albeit body weight remained significantly lower than in sham-operated animals. LVSP and LVEDP were normalized in the tamoxifen-treated OVX rats, whereas MAP remained elevated. Irbesartan partially reduced the body weight gain of the OVX rats and did not influence uterine atrophy. LVSP and MAP were normalized in irbesartan-treated OVX rats, whereas LVEDP remained elevated. These data demonstrate that irbesartan rather than tamoxifen was efficacious in normalizing MAP in the OVX rats without a secondary effect on the uterus.Key words: ovariectomy, hemodynamics, tamoxifen, AT1 receptor antagonists.

scholarly journals Effects of the AT1 -receptor antagonist eprosartan on the progression of left ventricular dysfunction in dogs with heart failure

2003 ◽  
Vol 138 (2) ◽  
pp. 301-309 ◽  
Author(s):  
George Suzuki ◽  
Takayuki Mishima ◽  
Elaine J Tanhehco ◽  
Victor G Sharov ◽  
Anastassia Todor ◽  
...  
Keyword(s):  
Heart Failure ◽  
Receptor Antagonist ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
At1 Receptor
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