scholarly journals Dexamethasone Prevents the Decrease of Bone Mineral Density in Type II Collagen-Induced Rat Arthritis Model

1998 ◽  
Vol 78 (2) ◽  
pp. 225-228 ◽  
Author(s):  
Takagi Toshiki ◽  
Tsao Peter W. ◽  
Totsuka Ryuichi ◽  
Suzuki Tatsuo ◽  
Murata Takashi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Mineral Density ◽  
Arthritis Model

LncRNA Urothelial Carcinoma-Associated 1 (UCA1) Regulates Rat Bone Marrow Mesenchymal Stem Cell Differentiation and Promotes Repair of Bone Defects

2019 ◽  
Vol 9 (10) ◽  
pp. 1441-1447
Author(s):  
Yucheng Li ◽  
Jiang Xin ◽  
Wencai Sun
Keyword(s):  
Bone Mineral Density ◽  
Bone Marrow ◽  
Bone Defect ◽  
Bone Mineral ◽  
Type Ii Collagen ◽  
Bone Defects ◽  
Control Group ◽  
Type Ii ◽  
Mineral Density ◽  
Alp Activity

Bone marrow mesenchymal stem cells (BMSCs) have characteristics of self-renewal and multidirectional differentiation. LncRNA UCA1 regulates BMSCs differentiation. Whether LncRNA UCA1 plays a role in bone defects remains unclear. BMSCs were randomly divided into control group, radiation group (6Gy), radiation + UCA1 group followed by analysis of the expression of LncRNA UCA1, RUNX2 and OPN by real time PCR, BMSCs proliferation by MTT assay as well as ALP activity. Healthy Sprague-Dawley rats were randomly divided into control group; bone defect group; UCA1 group, in which UCA1-transfected BMSCs were infused into bone defect rats followed by analysis of bone mineral density, ALP activity as well as the formation of type II collagen by ELISA. LncRNA UCA1 expression was significantly decreased in BMSCs of irradiated group, with decreased BMSCs proliferation, reduced expression of RUNX2 and OPN as well as decreased ALP activity (P < 0.05). Transfection of UCA1 significantly up-regulated LncRNA UCA1 expression in BMSCs, promoted BMSCs proliferation, increased the expression of RUNX2 and OPN, and the activity of ALP (P < 0.05). In addition, UCA1 promoted bone mineral density, increased ALP activity and type II collagen formation in rats with bone defect. LncRNA UCA1 promotes osteogenic differentiation of BMSCs, and targeting it might be a novel approach to promote bone remodeling at the bone defect site.

Bone mineral density in women with type II diabetes mellitus

2009 ◽  
Vol 4 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Ruth S. Weinstock ◽  
Robin S. Goland ◽  
Elizabeth Shane ◽  
Thomas L. Clemens ◽  
Robert Lindsay ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Mineral Density

The Long-Term Effect Of Specific Type II 5α-Reductase Inhibition With Finasteride on Bone Mineral Density in Men: Results of a 4-Year Placebo Controlled Trial

2002 ◽  
Vol 167 (5) ◽  
pp. 2105-2108 ◽  
Author(s):  
ALVIN M. MATSUMOTO ◽  
LISA TENOVER ◽  
MICHAEL McCLUNG ◽  
DAVID MOBLEY ◽  
JACK GELLER ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Controlled Trial ◽  
Term Effect ◽  
Type Ii ◽  
Mineral Density ◽  
Long Term Effect

scholarly journals Biomechanical investigation of four different fixation techniques in sacrum Denis type II fracture with low bone mineral density

2017 ◽  
Vol 36 (6) ◽  
pp. 1624-1629 ◽  
Author(s):  
Yves P. Acklin ◽  
Ivan Zderic ◽  
Robert G. Richards ◽  
Paul Schmitz ◽  
Boyko Gueorguiev ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Type Ii ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
Biomechanical Investigation ◽  
Fixation Techniques
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