scholarly journals Induction of CPP32-Like Activity and Inhibition of Interleukin 1β Converting Enzyme Activity in the Liver of a Mouse Concanavalin A-Induced Hepatitis Model

1998 ◽  
Vol 77 (3) ◽  
pp. 257-259 ◽  
Author(s):  
Toshihiro Okamoto ◽  
Tadashi Kobayashi ◽  
Naoki Tsuzuike ◽  
Kaoni Hara
Keyword(s):  
Enzyme Activity ◽  
Concanavalin A ◽  
Interleukin 1Β ◽  
Converting Enzyme

scholarly journals Chronic Hepatitis in Interferon-γ Transgenic Mice Is Associated With Elevated CPP32-Like Activity and Interleukin-1β-Converting Enzyme Activity Suppression

1999 ◽  
Vol 79 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Okamoto Toshihiro ◽  
Nakano Yoshihisa ◽  
Yamakawa Tomio ◽  
Hara Kaoru ◽  
Yamamura Ken-Ichi ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Chronic Hepatitis ◽  
Transgenic Mice ◽  
Interferon Γ ◽  
Interleukin 1Β ◽  
Converting Enzyme

scholarly journals Stability and oligomeric equilibria of refolded interleukin-1β converting enzyme.

1997 ◽  
Vol 272 (2) ◽  
pp. 1412
Author(s):  
Robert V. Talanian ◽  
Luan C. Dang ◽  
Catherine R. Ferenz ◽  
Maria C. Hackett ◽  
John A. Mankovich ◽  
...  
Keyword(s):  
Interleukin 1Β ◽  
Converting Enzyme

scholarly journals Pomelo fruit wastes are potentially valuable antioxidants, anti-inflammatories, antihypertensives, and antihyperglycemics

2021 ◽  
Author(s):  
Li-Yun Lin ◽  
Chi-Yun Huang ◽  
Kuan-Chou Chen ◽  
Robert Y. Peng
Keyword(s):  
Enzyme Activity ◽  
Hepg2 Cells ◽  
Protocatechuic Acid ◽  
Converting Enzyme ◽  
Coumaric Acid ◽  
Angiotensin Converting Enzyme Activity ◽  
Tnf Α ◽  
Ethanolic Extracts ◽  
Fruit Wastes ◽  
Considerable Loss

AbstractGrapefruit (G) parts contain abundant phenolic acids and flavonoids (PPNs and FLVs). The wastes created from exocarps, mesocarps (G wastes, GW) and waste blanching water (WBW) lead to a considerable loss of PPNs and FLVs. Here, we assessed Buntan (CB), Buntan Hayata (CBH), and Peiyu (CP) cultivars and observed considerable amounts of PPNs and FLVs. The ethanolic extracts of GW (GWE) and WBW contained gallic acid, protocatechuic acid, chlorogenic acid, caffeic acid, ferulic acid, coumaric acid, naringin, hesperidin, diosmin, quercetin, hesperetin, nobiletin, and tangeretin (GWC). GWE has previously been reported to be a relatively active antioxidant, anti-inflammatory (based on the expression of TNF-α in Raw264.7 cells), antihypertensive, and anti-hyperglycemic compound. The IC50 values for antihyperglycemic activity with WBW for α-amylase were as follows: CB (27.96 ± 0.03 mg/mL) < CP (28.13 ± 0.19 mg/mL) < CBH (41.60 ± 0.16 mg/mL), and those for α-glucosidase were CB (1.80 ± 0.03 mg/mL) < CP (2.97 ± 0.29 mg/mL) < CBH (9.10 ± 0.51 mg/mL). GWC upregulated Glut4 in HepG2 cells, as well as the insulin secretion capability, and intracellular levels in RIN-m5F cells, and it downregulated DPP4 in HepG2 cells. The IC50 values for the angiotensin-converting enzyme activity were: CBP (5.10 ± 0.02 mg/mL) < CB (7.24 ± 0.65 mg/mL) < CP (8.60 ± 2.03 mg/mL). Our results indicate that PPNs and FLVs present in GW are worth reclaiming.

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