scholarly journals Effect of 5-{3-[((2S)-l,4-Benzodioxan-2-ylmethyl)amino]propoxy}-1,3-benzodioxole HCl (MKC-242), a Novel 5-HT1A-Receptor Agonist, on Aggressive Behavior and Marble Burying Behavior in Mice

1998 ◽  
Vol 76 (3) ◽  
pp. 297-304 ◽  
Author(s):  
Michikazu Abe ◽  
Hiroshi Nakai ◽  
Reiko Tabata ◽  
Ken-Ichi Saito ◽  
Mitsuo Egawa
Keyword(s):  
Aggressive Behavior ◽  
Receptor Agonist ◽  
Marble Burying

scholarly journals The effect of 5-HT2a/2c receptor agonist microinjected into central amygdaloid nucleus and median preoptic area on maternal aggressive behavior in rats

2006 ◽  
Vol 28 (2) ◽  
pp. 130-134 ◽  
Author(s):  
Rosa Maria Martins de Almeida ◽  
Marcia Giovenardi ◽  
Simone Perroni da Silva ◽  
Verônica Paz de Oliveira ◽  
Dirson João Stein
Keyword(s):  
Aggressive Behavior ◽  
Receptor Agonist ◽  
Female Rats ◽  
Amygdaloid Nucleus ◽  
Preoptic Nucleus ◽  
Social Investigation ◽  
Maternal Aggression ◽  
Median Preoptic Nucleus ◽  
Central Amygdaloid Nucleus ◽  
Periaqueductal Grey Area

OBJECTIVE: Much evidence supports the hypothesis that 5-hydroxytryptamine (5-HT) activation is related to the inhibition of aggression. We examined potentially pro- and anti-aggressive effects of the 5-HT2A/2C receptor agonist on specific brain sites. METHOD: Female Wistar rats on the 7th day postpartum were microinjected with the selective 5-HT2A/2C receptor agonist, alpha-methyl-5-hydroxytryptamine maleate (0.2 to 1.0 µg/0.2 µl) into the central amygdaloid nucleus and median preoptic nucleus. For each brain area studied, the frequency of the behaviors: locomotion, social investigation, lateral threat, attacks (frontal and lateral), and biting the intruder were compared among the various treatments by an Analysis of Variance, followed when appropriate, by Tukey's test. RESULTS: Microinjection of the selective 5-HT2A/2C receptor agonist, a-methyl-5-hydroxytryptamine maleate into central amygdaloid nucleus increased maternal aggression in the absence of concurrent changes in non-aggressive behavior. By contrast, microinjection of the selective 5-HT2A/2C receptor agonist at several dilutions into the median preoptic nucleusdid not alter aggressive behavior. CONCLUSIONS: The current and earlier data with pro- and anti-aggressive effects of the 5-HT2a/2c receptor agonist, when microinjected into the median preoptic nucleus relative to the central amygdaloid nucleus, medial septum and periaqueductal grey area in female rats point to functionally separate serotonin receptor populations in the amygdaloid-septal-hypothalamic and periaqueductal gray matter areas controlling aggressive behavior. It is possible that amygdaloid 5-HT2a/2c receptors may increase aggressive behavior in lactating females as a result of changes in fear.

scholarly journals Infralimbic and dorsal raphé microinjection of the 5-HT1B receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice

2012 ◽  
Vol 222 (1) ◽  
pp. 117-128 ◽  
Author(s):  
S. Faccidomo ◽  
I. M. H. Quadros ◽  
A. Takahashi ◽  
E. W. Fish ◽  
K. A. Miczek
Keyword(s):  
Aggressive Behavior ◽  
Receptor Agonist ◽  
Dorsal Raphe ◽  
Male Mice ◽  
Dorsal Raphé

MKC-733, a selective 5-HT3 receptor agonist, stimulates fasting human antral motility

2001 ◽  
Vol 120 (5) ◽  
pp. A460-A461 ◽  
Author(s):  
N COLEMAN ◽  
J WRIGHT ◽  
M PARKER ◽  
R SPILLER
Keyword(s):  
Receptor Agonist ◽  
Antral Motility

1197: AT-Home Efficacy of an Intranasally Administered Melanocortin Receptor Agonist, PT-141, In Men with Erectile Dysfunction (ED)

2004 ◽  
Vol 171 (4S) ◽  
pp. 316-316
Author(s):  
Hunter Wessells ◽  
Harin Padma-Nathan ◽  
Jacob Rajfer ◽  
Robert Feldman ◽  
Raymond Rosen ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Receptor Agonist ◽  
Melanocortin Receptor ◽  
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