A Novel Angiotensin II-Receptor Antagonist, 606A, Induces Regression of Cardiac Hypertrophy, Augments Endothelium-Dependent Relaxation and Improves Renal Function in Stroke-Prone Spontaneously Hypertensive Rats

Yoshihiro Hashimoto; Yukie Kurosawa; Koichi Minami; Keiko Fushimi; Hiroshi Narita

doi:10.1254/jjp.76.185

A Novel Angiotensin II-Receptor Antagonist, 606A, Induces Regression of Cardiac Hypertrophy, Augments Endothelium-Dependent Relaxation and Improves Renal Function in Stroke-Prone Spontaneously Hypertensive Rats

The Japanese Journal of Pharmacology ◽

10.1254/jjp.76.185 ◽

1998 ◽

Vol 76 (2) ◽

pp. 185-192 ◽

Cited By ~ 12

Author(s):

Yoshihiro Hashimoto ◽

Yukie Kurosawa ◽

Koichi Minami ◽

Keiko Fushimi ◽

Hiroshi Narita

Keyword(s):

Renal Function ◽

Angiotensin Ii ◽

Cardiac Hypertrophy ◽

Spontaneously Hypertensive Rats ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist ◽

Spontaneously Hypertensive ◽

Regression Of Cardiac Hypertrophy ◽

Endothelium Dependent Relaxation

Download Full-text

TCV−116, a newly developed angiotensin II receptor antagonist, induces regression of cardiac hypertrophy through suppression of the tissue renin-angiotensin system in spontaneously hypertensive rats

Life Sciences ◽

10.1016/0024-3205(94)90133-3 ◽

1994 ◽

Vol 54 (25) ◽

pp. 1987-1994 ◽

Cited By ~ 11

Author(s):

Kenji Mizuno ◽

Susumu Niimura ◽

Ken Katoh ◽

Soitsu Fukuchi

Keyword(s):

Angiotensin Ii ◽

Cardiac Hypertrophy ◽

Spontaneously Hypertensive Rats ◽

Renin Angiotensin System ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist ◽

Angiotensin System ◽

Spontaneously Hypertensive ◽

Regression Of Cardiac Hypertrophy

Download Full-text

Effects of losartan, a nonpeptide angiotensin II receptor antagonist, on cardiac hypertrophy and the tissue angiotensin II content in spontaneously hypertensive rats

Life Sciences ◽

10.1016/0024-3205(92)90589-h ◽

1992 ◽

Vol 51 (5) ◽

pp. 367-374 ◽

Cited By ~ 43

Author(s):

Kenji Mizuno ◽

Makio Tani ◽

Shigeatsu Hashimoto ◽

Susumu Niimura ◽

Hironobu Sanada ◽

...

Keyword(s):

Angiotensin Ii ◽

Cardiac Hypertrophy ◽

Receptor Antagonist ◽

Spontaneously Hypertensive Rats ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist ◽

Spontaneously Hypertensive ◽

Tissue Angiotensin

Download Full-text

Effect of Angiotensin II Receptor Antagonist, TCV-116, on Cardiac Hypertrophy and Coronary Circulation in Spontaneously Hypertensive Rats

Japanese Heart Journal ◽

10.1536/ihj.36.540 ◽

1995 ◽

Vol 36 (4) ◽

pp. 540-540

Author(s):

Hiroshi Fujita ◽

Kazuo Takeda ◽

Kazue Nakamura ◽

Atsushi Uchida ◽

Hiroshi Itoh ◽

...

Keyword(s):

Angiotensin Ii ◽

Cardiac Hypertrophy ◽

Receptor Antagonist ◽

Spontaneously Hypertensive Rats ◽

Coronary Circulation ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist ◽

Spontaneously Hypertensive

Download Full-text

Kidney is an important target for the antihypertensive action of an angiotensin II receptor antagonist in spontaneously hypertensive rats.

Hypertension ◽

10.1161/01.hyp.21.6.1056 ◽

1993 ◽

Vol 21 (6_pt_2) ◽

pp. 1056-1061 ◽

Cited By ~ 23

Author(s):

J M Wood ◽

C R Schnell ◽

N R Levens

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Spontaneously Hypertensive Rats ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist ◽

Spontaneously Hypertensive ◽

Important Target ◽

Antihypertensive Action

Download Full-text

Diverse effects of Ace inhibitors and angiotensin II receptor antagonists on prevention of cardiac hypertrophy and collagen distribution in spontaneously hypertensive rats

International Journal of Cardiology ◽

10.1016/j.ijcard.2003.10.016 ◽

2004 ◽

Vol 97 (3) ◽

pp. 373-381 ◽

Cited By ~ 14

Author(s):

C. Gagnon ◽

F. Legault ◽

P. Geraldes ◽

J.-F. Tanguay ◽

C. Lambert

Keyword(s):

Angiotensin Ii ◽

Cardiac Hypertrophy ◽

Ace Inhibitors ◽

Spontaneously Hypertensive Rats ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Spontaneously Hypertensive

Download Full-text

Effect of chronic administration of TCV-116, a novel nonpeptide angiotensin II receptor antagonist, on vasoconstrictor response to sympathetic nerve stimulation in spontaneously hypertensive rats (SHR)

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)40969-4 ◽

1998 ◽

Vol 76 ◽

pp. 215

Author(s):

Masatoshi Okazaki ◽

Hiromu Kawasaki ◽

Akira Nakatsuma ◽

Yuichi Mimaki ◽

Hiroaki Araki ◽

...

Keyword(s):

Angiotensin Ii ◽

Nerve Stimulation ◽

Spontaneously Hypertensive Rats ◽

Chronic Administration ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist ◽

Sympathetic Nerve Stimulation ◽

Spontaneously Hypertensive ◽

Vasoconstrictor Response

Download Full-text

Central administration of a specific angiotensin II receptor antagonist on baroreflex function in spontaneously hypertensive rats

Journal of Hypertension ◽

10.1097/00004872-199104000-00009 ◽

1991 ◽

Vol 9 (4) ◽

pp. 365-371 ◽

Cited By ~ 30

Author(s):

Kathleen H. Berecek ◽

Joel D. Robertson ◽

M Hernandez Thorstad

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Spontaneously Hypertensive Rats ◽

Central Administration ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist ◽

Spontaneously Hypertensive ◽

Baroreflex Function

Download Full-text

Aldosterone Breakthrough During Angiotensin II Receptor Antagonist Therapy in Stroke-Prone Spontaneously Hypertensive Rats

Hypertension ◽

10.1161/01.hyp.0000022606.52221.2f ◽

2002 ◽

Vol 40 (1) ◽

pp. 28-33 ◽

Cited By ~ 88

Author(s):

Mitsuhide Naruse ◽

Akiyo Tanabe ◽

Atsuhisa Sato ◽

Sachiko Takagi ◽

Ken Tsuchiya ◽

...

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Spontaneously Hypertensive Rats ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist ◽

Antagonist Therapy ◽

Spontaneously Hypertensive ◽

Aldosterone Breakthrough

Download Full-text

Effects of a Specific Angiotensin II Receptor Antagonist on the Vascular Renin-Angiotensin System in Spontaneously Hypertensive Rats

Japanese Heart Journal ◽

10.1536/ihj.34.499 ◽

1993 ◽

Vol 34 (4) ◽

pp. 499-499

Author(s):

Shang Jin Shi ◽

Koichi Higashimori ◽

Jitsuo Higaki ◽

Hiroshi Mikami ◽

Toshio Ogihara

Keyword(s):

Angiotensin Ii ◽

Receptor Antagonist ◽

Spontaneously Hypertensive Rats ◽

Renin Angiotensin System ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist ◽

Angiotensin System ◽

Spontaneously Hypertensive ◽

Renin Angiotensin

Download Full-text

Comparison of the effects of angiotensin II receptor antagonist monotherapy and combination therapy with a diuretic on cardiac function in spontaneously hypertensive rats

Journal of Echocardiography ◽

10.1007/s12574-012-0141-1 ◽

2012 ◽

Vol 10 (4) ◽

pp. 125-131 ◽

Cited By ~ 1

Author(s):

Kasumi Masuda ◽

Hiroki Taenaka ◽

Toshihiko Asanuma ◽

Satoshi Nakatani

Keyword(s):

Angiotensin Ii ◽

Combination Therapy ◽

Cardiac Function ◽

Receptor Antagonist ◽

Spontaneously Hypertensive Rats ◽

Angiotensin Ii Receptor ◽

Hypertensive Rats ◽

Angiotensin Ii Receptor Antagonist ◽

Spontaneously Hypertensive

Download Full-text