scholarly journals Shortening of Monophasic Action Potential Duration During Hyperkalemia and Myocardial Ischemia in Anesthetized Dogs

1998 ◽  
Vol 76 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Kaori Hamada ◽  
Jun Yamazaki ◽  
Taku Nagao
Keyword(s):  
Myocardial Ischemia ◽  
Action Potential ◽  
Action Potential Duration ◽  
Monophasic Action Potential ◽  
Anesthetized Dogs

Influence of IV Haloperidol on Ventricular Repolarization and Monophasic Action Potential Duration in Anesthetized Dogs

CHEST Journal ◽  
2004 ◽  
Vol 125 (5) ◽  
pp. 1821-1829 ◽  
Author(s):  
Saeed Rasty ◽  
Neeta B. Amin ◽  
Hani N. Sabbah ◽  
Takayuki Mishima ◽  
Steven Borzak ◽  
...  
Keyword(s):  
Action Potential ◽  
Action Potential Duration ◽  
Ventricular Repolarization ◽  
Monophasic Action Potential ◽  
Anesthetized Dogs

Effect of sotalol, aprindine and the combination aprindine—sotalol on monophasic action potential duration

1986 ◽  
Vol 7 (1) ◽  
pp. 47-53 ◽  
Author(s):  
R. STROOBANDT ◽  
J. BRACHMANN ◽  
H. KESTELOOT ◽  
W. KÜBLER ◽  
J. SENGES
Keyword(s):  
Action Potential ◽  
Action Potential Duration ◽  
Monophasic Action Potential

scholarly journals Effects of Volatile Anesthetics on Atrial and AV Nodal Electrophysiological Properties in Guinea Pig Isolated Perfused Heart 

1998 ◽  
Vol 89 (2) ◽  
pp. 434-442 ◽  
Author(s):  
Pekka M. J. Raatikainen ◽  
Mark F. Trankina ◽  
Timothy E. Morey ◽  
Donn M. Dennis
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Action Potential Duration ◽  
Volatile Anesthetics ◽  
Monophasic Action Potential ◽  
Computer Assisted ◽  
Conduction Time ◽  
Av Node ◽  
Refractory Periods ◽  
Supraventricular Tachycardias

Background Knowledge of the anesthetic effects on atrial and atrioventricular (AV) nodal electrophysiologic properties is fundamental to understand the modulatory role of anesthetics on the pathogenesis of supraventricular tachycardias, and to individualize the perioperative management of patients with supraventricular tachycardias or AV nodal conduction disturbances. Therefore the authors studied the effects of three commonly used volatile anesthetics on the electrophysiologic properties of the atrium and AV node. Methods The concentration-dependent electrophysiologic effects of halothane, isoflurane, and desflurane (0-2 minimum alveolar concentration [MAC]) were studied in guinea pig Langendorff-perfused hearts fit with instruments to simultaneously measure atrial and AV nodal conduction times and atrial monophasic action potential duration. Atrial and AV nodal effective refractory periods were measured simultaneously using a computer-assisted premature stimulation protocol. The concentrations of anesthetics in the gas phase were monitored by an infrared gas analyzer. Results Volatile anesthetics caused markedly different concentration-dependent effects on atrial conduction, repolarization, and refractoriness, and on AV nodal function. At equianesthetic concentrations, halothane depressed atrial conduction the most, whereas desflurane caused the greatest shortening of atrial monophasic action potential duration. Halothane had no significant effect on atrial refractoriness, whereas at 2 MAC desflurane significantly shortened and isoflurane significantly prolonged atrial effective refractory periods by 18.1+/-13.5% and 13.2+/-14.7%, respectively. On an equi-MAC basis, the rank order of potency for the anesthetics to prolong AV nodal conduction time and AV nodal ERP was halothane > desflurane > isoflurane. Conclusion The different electrophysiologic effects of volatile anesthetics in the atrium and AV node suggest that these agents may modulate atrial dysrhythmogenesis in distinctly different ways.

DYNAMICAL EFFECTS OF MYOCARDIAL ISCHEMIA IN ANISOTROPIC CARDIAC MODELS IN THREE DIMENSIONS

2007 ◽  
Vol 17 (12) ◽  
pp. 1965-2008 ◽  
Author(s):  
PIERO COLLI FRANZONE ◽  
LUCA F. PAVARINO ◽  
SIMONE SCACCHI
Keyword(s):  
Myocardial Ischemia ◽  
Action Potential ◽  
Numerical Simulations ◽  
Cardiac Muscle ◽  
Action Potential Duration ◽  
Three Dimensions ◽  
Extracellular Potential ◽  
Anisotropic Structure ◽  
Orthogonal Components ◽  
Cardiac Excitation

The interaction between the presence of moderate or severe subendocardial ischemic regions and the anisotropic structure of the cardiac muscle is investigated here by means of numerical simulations based on anisotropic Bidomain and Monodomain models. The ischemic effects on cardiac excitation, recovery and distribution of action potential duration are discussed, showing the presence of ischemic epicardial markers. Extracellular potential distributions during the ST and TQ intervals are computed separately using non-stationary models. During the ST interval, the extracellular potential patterns differ from those simulated with stationary models used in the literature. These differences are explained by decomposing the cardiac current sources into conormal, axial and orthogonal components and by determining which component is dominant during the ST and TQ intervals.

Sign in / Sign up

Export Citation Format

Share Document