scholarly journals Effects of Various Selective Phosphodiesterase Inhibitors on Muscle Contractility in Guinea Pig Ileal Longitudinal Smooth Muscle.

1997 ◽  
Vol 75 (1) ◽  
pp. 77-85 ◽  
Author(s):  
Takeharu Kaneda ◽  
Kazumasa Shimizu ◽  
Shinjiro Nakajyo ◽  
Norimoto Urakawa
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Phosphodiesterase Inhibitors ◽  
Muscle Contractility ◽  
Longitudinal Smooth Muscle

Characterization of the effects of AHN 086, an irreversible ligand of "peripheral" benzodiazepine receptors, on contraction in guinea-pig atria and ileal longitudinal smooth muscle

1989 ◽  
Vol 67 (2) ◽  
pp. 126-134 ◽  
Author(s):  
G. T. Bolger ◽  
A. H. Newman ◽  
K. C. Rice ◽  
H. W. M. Lueddens ◽  
A. S. Basile ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Calcium Channels ◽  
Benzodiazepine Receptors ◽  
Significant Inhibition ◽  
Bay K 8644 ◽  
Longitudinal Smooth Muscle ◽  
Peripheral Benzodiazepine Receptors ◽  
Inotropic Responses ◽  
Guinea Pig Atria

The effects of AHN 086 and its reversibly acting structural analogue Ro 5-4864 were studied in the spontaneously beating guinea-pig atria and field-stimulated guinea-pig ileal longitudinal smooth muscle in the presence and absence of dihydropyridine calcium channel modulators. The treatment of guinea-pig atria with AHN 086 followed by extensive washing did not alter contraction. However, AHN 086 (0.5 μM) potentiated (88%) the positive inotropic responses by BAY K 8644, an effect that was not reversed by extensive washing of the tissue. Higher concentrations of AHN 086 (> 2 μM) irreversibly inhibited the intropic, but not the chronotropic responses to BAY K 8644, nifedipine, and isoproterenol. Ro 5-4864 (10 μM) produced a reversible enhancement of the inotropic responses and block of the chronotropic responses to BAY K 8644. In guinea-pig ileal longitudinal smooth muscle, both AHN 086 and Ro 5-4864 reversibly inhibited field-stimulated contractions. Neither Ro 5-4864 nor AHN 086 affected the ability of nifedipine to inhibit field-stimulated contractions of ileal longitudinal smooth muscle. Treatment of intact atria with 5 μM AHN 086 followed by extensive washing resulted in a significant inhibition (30–50%) of [3H]Ro 5-4864 binding to peripheral benzodiazepine receptors and of [3H]nitrendipine binding to voltage-operated calcium channels, but did not affect [3H]dihydroalprenolol binding to β-adrenergic receptors on atrial membranes. The same treatment applied to intact ileal longitudinal smooth muscle affected neither [3H] (−)-quinuclidinyl benzilate binding to muscarine receptors nor [3H]nitrendipine binding, but did result in a significant inhibition (30–50%) of [3H]Ro 5-4864 binding to ileal longitudinal smooth muscle membranes. The pharmacology of AHN 086 suggests that there is a different relationship between peripheral benzodiazepine receptors and voltage-operated calcium channels in guinea-pig atria and ileal longitudinal smooth muscle.Key words: calcium channels, peripheral benzodiazepine receptors, dihydropyridines, benzodiazepines, dihydropyridine binding sites.

The development and reversal of the tolerance to morphine in the longitudinal smooth muscle-myenteric plexus preparation of the guinea pig

Life Sciences ◽  
1989 ◽  
Vol 45 (16) ◽  
pp. 1483-1489 ◽  
Author(s):  
Judith A. Leedham ◽  
Nancy Doak ◽  
David A. Taylor ◽  
William W. Fleming
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Longitudinal Smooth Muscle

Mechanisms of PTHrP-induced inhibition of smooth muscle contractility in the guinea pig gastric antrum

2017 ◽  
Vol 29 (12) ◽  
pp. e13142
Author(s):  
H. Ohguchi ◽  
R. Mitsui ◽  
K. Imaeda ◽  
T. Joh ◽  
H. Hashitani
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Gastric Antrum ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility
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