scholarly journals Histamine H2-Receptor Antagonism of T-593: Studies on Positive Chronotropic Responses in Guinea Pig Atria

1994 ◽  
Vol 64 (4) ◽  
pp. 251-256 ◽  
Author(s):  
Hirotoshi Arai ◽  
Masaya Nakagawa ◽  
Kikuko Tanada ◽  
Hidetoshi Yamaguchi ◽  
Shiro Hirai
Keyword(s):  
Guinea Pig ◽  
Histamine H2 Receptor ◽  
Receptor Antagonism ◽  
H2 Receptor ◽  
Guinea Pig Atria

Distinct Interaction of Human and Guinea Pig Histamine H2-Receptor with Guanidine-Type Agonists

2001 ◽  
Vol 60 (6) ◽  
pp. 1210-1225 ◽  
Author(s):  
Melissa T. Kelley ◽  
Tilmann Bürckstümmer ◽  
Katharina Wenzel-Seifert ◽  
Stefan Dove ◽  
Armin Buschauer ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Histamine H2 Receptor ◽  
H2 Receptor

Cholinergic and VIP-ergic pathways mediate histamine H2 receptor-induced cyclical secretion in the guinea pig colon

1995 ◽  
Vol 268 (3) ◽  
pp. G465-G470 ◽  
Author(s):  
H. J. Cooke ◽  
Y. Z. Wang ◽  
R. Reddix ◽  
N. Javed
Keyword(s):  
Guinea Pig ◽  
Channel Blocker ◽  
Short Circuit ◽  
Cholinergic Neurons ◽  
Distal Colon ◽  
Neural Pathways ◽  
Histamine H2 Receptor ◽  
Muscarinic Antagonist ◽  
H2 Receptor ◽  
Anion Secretion

Previous studies demonstrated neurally mediated recurrent increases in short-circuit current (Isc) suggestive of anion secretion in guinea pig distal colon. To determine the neural pathways involved, segments of distal colon from guinea pigs were mounted in flux chambers. In muscle-stripped or whole thickness preparations, serosal addition of the histamine H2 receptor agonist, dimaprit, caused cyclical increases in Isc, which were reduced by the chloride channel blocker, N-phenylanthranilic acid, but not by the sodium channel blocker amiloride. Dimaprit stimulated release of [3H]acetylcholine and vasoactive intestinal polypeptide (VIP) from submucosal/mucosal sheets. Dimaprit caused recurrent increases in Isc, which were significantly decreased by mecamylamine, a nicotinic receptor antagonist, and nearly abolished by the muscarinic antagonist, atropine (M3 > M1 = M2). The muscarinic antagonist, 4-diphenylacetoxy-N-methyl-piperidine methiodide (4-DAMP, M3 > M1), was more potent than pirenzepine (M1 > M3) in reducing recurrent increases in Isc. Dimaprit- and electrically evoked secretion were inhibited by the VIP antagonists [4Cl-D-Phe6, Leu17]VIP and VIP hybrid. The results suggest the involvement of VIP-ergic and cholinergic neurons utilizing nicotinic and muscarinic synapses in mediating secretion.

Effect of histamine H2 receptor antagonism on levodopa-induced dyskinesia in the MPTP-macaque model of Parkinson's disease

2010 ◽  
Vol 25 (10) ◽  
pp. 1379-1390 ◽  
Author(s):  
Tom H. Johnston ◽  
Anne van der Meij ◽  
Jonathan M. Brotchie ◽  
Susan H. Fox
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Histamine H2 Receptor ◽  
Receptor Antagonism ◽  
H2 Receptor ◽  
Macaque Model
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