scholarly journals Pharmacological Profiles of Aspergillomarasmines as Endothelin Converting Enzyme Inhibitors

1993 ◽  
Vol 63 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Akihiro Matsuura ◽  
Hiroshi Okumura ◽  
Rieko Asakura ◽  
Naoki Ashizawa ◽  
Mayumi Takahashi ◽  
...  
Keyword(s):  
Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Endothelin Converting Enzyme ◽  
Pharmacological Profiles

Endothelin-Converting Enzyme Inhibitors

2006 ◽  
Vol 2 (4) ◽  
pp. 373-378 ◽  
Author(s):  
Cristina Navarrete ◽  
Cleide Suguihara
Keyword(s):  
Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Endothelin Converting Enzyme

Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications

2002 ◽  
Vol 80 (5) ◽  
pp. 440-449 ◽  
Author(s):  
Arco Y Jeng ◽  
Paul Mulder ◽  
Aij-Lie Kwan ◽  
Bruno Battistini
Keyword(s):  
Amino Acid Sequence Identity ◽  
Enzyme Inhibitors ◽  
Neutral Endopeptidase ◽  
Therapeutic Agents ◽  
Converting Enzyme ◽  
Central Nervous System Diseases ◽  
Converting Enzyme Inhibitors ◽  
Endothelin Converting Enzyme ◽  
Significant Amino Acid Sequence ◽  
Significant Amino Acid

Endothelins (ETs) are potent vasoconstrictors, promitogens, and inflammatory mediators. They have been implicated in the pathogenesis of various cardiovascular, renal, pulmonary, and central nervous system diseases. Since the final step of the biosynthesis of ETs is catalyzed by a family of endothelin-converting enzymes (ECEs), inhibitors of these enzymes may represent novel therapeutic agents. Currently, seven isoforms of these metalloproteases have been identified; they all share a significant amino acid sequence identity with neutral endopeptidase 24.11 (NEP), another metalloprotease. Therefore, it is not surprising that the majority of ECE inhibitors also possess potent NEP inhibitory activity. To date, three classes of ECE inhibitors have been synthesized: dual ECE/NEP inhibitors, triple ECE/NEP/ACE inhibitors, and selective ECE inhibitors. Potential clinical applications of these compounds in hypertension, chronic heart failure, restenosis, renal failure, and cerebral vasospasm deduced from studies with relevant animal models are reviewed.Key words: endothelin-converting enzyme, ECE, inhibitors, phosphoramidon, CGS 26303, CGS 35066, FR 901533, SCH 54470, metalloprotease.

scholarly journals Highly sensitive and selective fluorescence assays for rapid screening of endothelin-converting enzyme inhibitors

2001 ◽  
Vol 356 (3) ◽  
pp. 813 ◽  
Author(s):  
Nathalie LUCIANI ◽  
Hugues de ROCQUIGNY ◽  
Serge Turcaud ◽  
Anthony ROMIEU ◽  
Bernard P. ROQUES
Keyword(s):  
Enzyme Inhibitors ◽  
Rapid Screening ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Highly Sensitive ◽  
Endothelin Converting Enzyme ◽  
Fluorescence Assays
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