scholarly journals Non-Competitive Antagonism by Hirsuteine of Nicotinic Receptor-Mediated Dopamine Release from Rat Pheochromocytoma Cells

1993 ◽  
Vol 62 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Tomokazu Watano ◽  
Ken Nakazawa ◽  
Tomoko Obama ◽  
Mayumi Mori ◽  
Kazuhide Inoue ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Dopamine Release ◽  
Pheochromocytoma Cells ◽  
Competitive Antagonism

scholarly journals r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement

2015 ◽  
Vol 40 (10) ◽  
pp. 2121-2130 ◽  
Author(s):  
Joshua S. Beckmann ◽  
Andrew C. Meyer ◽  
M. Pivavarchyk ◽  
David B. Horton ◽  
Guangrong Zheng ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Nicotinic Receptor ◽  
Dopamine Release ◽  
Nicotinic Receptor Antagonist

scholarly journals Indolizidine (−)-235B′ and related structural analogs: Discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release

2011 ◽  
Vol 658 (2-3) ◽  
pp. 132-139 ◽  
Author(s):  
Marharyta Pivavarchyk ◽  
Andrew M. Smith ◽  
Zhenfa Zhang ◽  
Dejun Zhou ◽  
Xu Wang ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Dopamine Release ◽  
Receptor Antagonists

Physostigmine, galanthamine and codeine act as ‘noncompetitive nicotinic receptor agonists’ on clonal rat pheochromocytoma cells

1995 ◽  
Vol 290 (3) ◽  
pp. 207-219 ◽  
Author(s):  
Alexander Storch ◽  
André Schrattenholz ◽  
Julia C. Cooper ◽  
El Moeiz Abdel Ghani ◽  
Oliver Gutbrod ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Pheochromocytoma Cells ◽  
Receptor Agonists

scholarly journals Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure

2019 ◽  
Author(s):  
Ashley M. Fennell ◽  
Elizabeth G. Pitts ◽  
Lacey L. Sexton ◽  
Mark J. Ferris
Keyword(s):  
Substance Use ◽  
Individual Differences ◽  
Substance Use Disorder ◽  
Nicotinic Receptor ◽  
Dopamine Release ◽  
The United States ◽  
Locomotor Sensitization ◽  
Nicotine Exposure ◽  
Behavioral Models ◽  
Sprague Dawley

AbstractSmoking remains the primary cause of preventable death in the United States and smoking related illness costs more than $300 billion annually. Nicotine (the primary reinforcer in cigarettes) causes changes in behavior and neurochemistry that lead to increased probability of relapse. Given the role of mesolimbic dopamine projections in motivation, substance use disorder, and drug relapse, we examined the effect of repeated nicotine on rapid dopamine signals in the nucleus accumbens (NAc) of rats. Adult, male Sprague-Dawley rats were exposed to nicotine (0.2 or 0.4 mg/kg, subcutaneous) once daily for 7 days. On day 8, dopamine release and uptake dynamics, and their modulation by nicotinic receptor agonists and antagonists, were assessed using fast scan cyclic voltammetry in the NAc core. Nicotine exposure decreased electrically-stimulated dopamine release across a range of stimulation frequencies and decreased α6β2-containing nicotinic receptor control over dopamine release. Additionally, nicotine locomotor sensitization correlated with accumbal dopamine modulation by nicotine and mecamylamine. Taken together, our study suggests that repeated exposure to nicotine blunts dopamine release in the NAc core through changes in α6β2 modulation of dopamine release and individual differences in the sensitivity to this outcome may predict variation in behavioral models of vulnerability to substance use disorder.

scholarly journals Antagonism of nicotinic receptor-mediated dopamine release by hirsuteine, an alkaloid extracted from Uncalia genous

1992 ◽  
Vol 58 ◽  
pp. 369
Author(s):  
Tomokazu Watano ◽  
Ken Nakazawa ◽  
Kazuhide Inoue ◽  
Tomoko Obama ◽  
Mayumi Mori ◽  
...  
Keyword(s):  
Nicotinic Receptor ◽  
Dopamine Release

Identification of coffee components that stimulate dopamine release from pheochromocytoma cells (PC-12)

2012 ◽  
Vol 50 (2) ◽  
pp. 390-398 ◽  
Author(s):  
J. Walker ◽  
B. Rohm ◽  
R. Lang ◽  
M.W. Pariza ◽  
T. Hofmann ◽  
...  
Keyword(s):  
Dopamine Release ◽  
Pheochromocytoma Cells
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