scholarly journals Blockade of Retinal NMDA Receptors by Sodium Nitroprusside Is Probably Due to Nitric Oxide Formation

1993 ◽  
Vol 62 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Hisamitsu Ujihara ◽  
Akinori Akaike ◽  
Yutaka Tamura ◽  
Takeharu Yokota ◽  
Masashi Sasa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nmda Receptors ◽  
Sodium Nitroprusside ◽  
Oxide Formation ◽  
Nitric Oxide Formation

Interaction of glyceryl trinitrate and sodium nitroprusside with bovine pulmonary vein homogenate and 10 000 × g supernatant: biotransformation and nitric oxide formation

1991 ◽  
Vol 69 (6) ◽  
pp. 889-892 ◽  
Author(s):  
Gerald S. Marks ◽  
Brian E. McLaughlin ◽  
Leslie B. Brown ◽  
Danielle E. Beaton ◽  
Brian P. Booth ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glyceryl Trinitrate ◽  
Sodium Nitroprusside ◽  
Pulmonary Vein ◽  
Argon Atmosphere ◽  
Supernatant Fraction ◽  
Gas Liquid Chromatography ◽  
Oxide Formation ◽  
Nitric Oxide Formation ◽  
Headspace Gas

The current proposed mechanism of action of nitrovasodilator drugs involves biotransformation to nitric oxide, which is postulated to be the active vasodilator substance. Our objective was to determine whether nitric oxide was formed from two prototype nitrovasodilator drugs, glyceryl trinitrate (GTN) and sodium nitroprusside (SNP), after incubation with bovine pulmonary vein (BPV) preparations. GTN or SNP was incubated in an argon atmosphere with phosphate buffer, BPV homogenate, or the 10 000 × g supernatant fraction of the homogenate. Nitric oxide formation, as determined by a chemiluminescence – headspace gas method, was measurable following the incubation of SNP with BPV homogenate and 10 000 × g supernatant. There was no detectable formation of nitric oxide from the incubation of GTN with the two BPV preparations, although GTN was biotransformed to glyceryl dinitrate, as determined by gas–liquid chromatography. There was decreased recovery of nitric oxide during the incubation of authentic nitric oxide with the two BPV preparations as compared with buffer. In conclusion, formation of nitric oxide was measured for the interaction of SNP, but not GTN, with BPV preparations. However, the data do not exclude the possible formation of nitric oxide from GTN, as nitric oxide was shown to be sequestered or transformed by the BPV preparations.Key words: glyceryl trinitrate, sodium nitroprusside, nitric oxide formation, bovine pulmonary vein.

Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction

Diabetes ◽  
1992 ◽  
Vol 41 (4) ◽  
pp. 552-556 ◽  
Author(s):  
J. A. Corbett ◽  
R. G. Tilton ◽  
K. Chang ◽  
K. S. Hasan ◽  
Y. Ido ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vascular Dysfunction ◽  
Oxide Formation ◽  
Nitric Oxide Formation

scholarly journals Nitric oxide formation during light-induced decomposition of phenyl N-tert-butylnitrone

1993 ◽  
Vol 268 (16) ◽  
pp. 11520-11527
Author(s):  
W. Chamulitrat ◽  
S.J. Jordan ◽  
R.P. Mason ◽  
K. Saito ◽  
R.G. Cutler
Keyword(s):  
Nitric Oxide ◽  
Oxide Formation ◽  
Nitric Oxide Formation ◽  
Induced Decomposition

scholarly journals Zinc regulates iNOS-derived nitric oxide formation in endothelial cells

Redox Biology ◽  
2014 ◽  
Vol 2 ◽  
pp. 945-954 ◽  
Author(s):  
Miriam M. Cortese-Krott ◽  
Larissa Kulakov ◽  
Christian Opländer ◽  
Victoria Kolb-Bachofen ◽  
Klaus-D. Kröncke ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Oxide Formation ◽  
Nitric Oxide Formation

Room F, 10/17/2000 9: 00 AM - 11: 00 AM (PS) Interleukin-10 Inhibits Nitric Oxide Formation in Murine Macrophages by Suppressing CAT-2 Transcription 

2000 ◽  
Vol 93 (3A) ◽  
pp. A-451
Author(s):  
Chun-Jen Huang ◽  
R. B. Nielsen ◽  
David R. Nelson ◽  
Bruce R. Stevens ◽  
Jeffrey W. Skimming
Keyword(s):  
Nitric Oxide ◽  
Interleukin 10 ◽  
Oxide Formation ◽  
Murine Macrophages ◽  
Nitric Oxide Formation
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