scholarly journals Effects of KW-3635, a Novel Dibenzoxepin Derivative of a Selective Thromboxane A2 Antagonist, on Human, Guinea Pig and Rat Platelets.

1992 ◽  
Vol 59 (3) ◽  
pp. 357-364 ◽  
Author(s):  
Ichiro Miki ◽  
Nobuyuki Kishibayashi ◽  
Hiromi Nonaka ◽  
Etsuo Ohshima ◽  
Hitoshi Takami ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Thromboxane A2 ◽  
Rat Platelets ◽  
Thromboxane A2 Antagonist

scholarly journals Effects of KW-3635, a Novel Dibenzoxepin Derivative of a Selective Thromboxane A2 Antagonist, on Human, Guinea Pig and Rat Platelets

1992 ◽  
Vol 59 (3) ◽  
pp. 357-364
Author(s):  
Ichiro Miki ◽  
Nobuyuki Kishibayashi ◽  
Hiromi Nonaka ◽  
Etsuo Ohshima ◽  
Hitoshi Takami ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Thromboxane A2 ◽  
Rat Platelets ◽  
Thromboxane A2 Antagonist

Effect of Ridogrel on Vascular Contractions Gaused by Vasoactive Substances Released during Platelet Activation

1990 ◽  
Vol 64 (01) ◽  
pp. 091-096 ◽  
Author(s):  
W J Janssens ◽  
F J S Cools ◽  
L A M Hoskens ◽  
J M Van Nueten
Keyword(s):  
Smooth Muscle ◽  
Blood Vessel ◽  
Platelet Activation ◽  
Prostaglandin F2α ◽  
Thromboxane A2 ◽  
Femoral Arteries ◽  
Vasoactive Substances ◽  
Caudal Artery ◽  
Isolated Rat ◽  
Rat Platelets

SummaryRidogrel (6.3 × 10−6 to 10−4 M) inhibited contractions of isolated rat caudal arteries and rabbit femoral arteries caused by U-46619. The slope of an Arunlakshana-Schild plot (pA2-value: 3.4 × 10−6 M) on the caudal artery was slightly higher than one (1.14). This effect was maximal within}D min of incubation of the blood vessel with the compound and easily reversible. Ridogrel antagonised contractions of isolated rabbit femoral arteries caused by prostaglandin Fzo2α in the same concentration range. Ridogrel also inhibited contractions induced by aggregating rat platelets on isolated rat caudal arteries (itt the presence of ketanserin 4 × 10−7 M) and on isolated rabbit pulmonary and femoral arteries (in the absence of ketanserin). Ridogrel had no effect on Ca2+-induced contractions in depolarised isolated rabbit femoral arteries, and at 10−4 M antagonised serotonin-induced contractions in this blood vessel. Its effect on serotonin-induced contractions was statistically significant but very small on isolated rat caudal arteries. These observations indicate that ridogrel is an antagonist of prostaglandin endoperoxide/thromboxane A2 and prostaglandin F2α raCeptors on vascular smooth muscle.

scholarly journals Role of thromboxane A2 in guinea pig complement-mediated respiratory disorders

1990 ◽  
Vol 52 ◽  
pp. 305
Author(s):  
Fumitoshi Asai ◽  
Atsuhiro Sugidachi ◽  
Takako Nagasawa ◽  
Naoko Yazawa ◽  
Kayoko Arai ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Thromboxane A2 ◽  
Respiratory Disorders
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