scholarly journals The Effect of Cimetidine on Adaptive Cytoprotection by Mild Irritant Dose of HC1 in the Rat Gastric Mucosa

1991 ◽  
Vol 57 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Shinichi Ota ◽  
Hideyuki Hiraishi ◽  
Akira Terano ◽  
Hiroyuki Mutoh ◽  
Yasuo Hata ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Adaptive Cytoprotection ◽  
Rat Gastric Mucosa ◽  
Mild Irritant

Adaptive cytoprotection by 0.25 M HCl is truly "cytoprotective" and may not depend upon elevated levels of prostaglandin synthesis

1988 ◽  
Vol 66 (8) ◽  
pp. 1075-1081 ◽  
Author(s):  
W. K. MacNaughton ◽  
T. E. Williamson ◽  
G. P. Morris
Keyword(s):  
Ex Vivo ◽  
Potential Difference ◽  
Surface Epithelium ◽  
Lesion Area ◽  
Damage Potential ◽  
Adaptive Cytoprotection ◽  
Epithelial Damage ◽  
Subsequent Exposure ◽  
Rat Gastric Mucosa ◽  
Mild Irritant

The ability of a mild irritant to reduce ethanol-induced damage to the rat gastric mucosa was investigated using an ex vivo gastric chamber preparation. Exposure to 0.25 M hydrochloric acid (HCl) did not cause significant damage to the surface epithelium, but did reduce both the lesion area and the extent of superficial epithelial damage caused by subsequent exposure to 40% ethanol (EtOH). "Adaptive cytoprotection" was also demonstrated by the reduction of ethanol-induced changes in transmural potential difference and net K+ efflux, and by rapid recovery of these physiological parameters following the removal of ethanol from the chamber. Pretreatment of rats with indomethacin at a dose that has been shown to significantly inhibit gastric cyclooxygenase activity did not significantly affect the ability of 0.25 M HCl to reduce the effects of ethanol on lesion area, epithelial damage, potential difference, and net K+ efflux.

scholarly journals Vinegar is a Dietary Mild Irritant to the Rat Gastric Mucosa

1986 ◽  
Vol 41 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Youichi NOBUHARA ◽  
Koji TAKEUCHI ◽  
Susumu OKABE
Keyword(s):  
Gastric Mucosa ◽  
Rat Gastric Mucosa ◽  
Mild Irritant

Role of complement regulatory membrane proteins in ischaemia-reperfusion injury of rat gastric mucosa

1999 ◽  
Vol 14 (10) ◽  
pp. 967-972 ◽  
Author(s):  
Fumihiro Iwata ◽  
Takashi Joh ◽  
Toyohiro Tada ◽  
Noriko Okada ◽  
B Paul Morgan ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Membrane Proteins ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Rat Gastric Mucosa
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