scholarly journals Salivary peptide P-C modulates both insulin and glucagon release from isolated perfused rat pancreas.

1990 ◽  
Vol 52 (4) ◽  
pp. 579-585 ◽  
Author(s):  
Masayasu KIMURA ◽  
Noboru NAKASHIMA ◽  
Ikuko KIMURA
1983 ◽  
Vol 245 (4) ◽  
pp. E313-E317
Author(s):  
J. Szecowka ◽  
D. Tendler ◽  
S. Efendic

Effects of the novel gastrointestinal polypeptide PHI with N-terminal histidine, C-terminal isoleucine amide, and 27 amino acids have been studied in isolated perfused rat pancreas. PHI increased the release of insulin, glucagon, and somatostatin. The amounts of these hormones released were strictly dependent on the prevailing glucose concentrations. In the absence of glucose, PHI (1 nmol/liter) stimulated glucagon release. In the presence of 4.4 and 6.7 mmol/liter glucose, the same dose of this peptide stimulated insulin and somatostatin release. In the presence of 16.7 mmol/liter glucose, only insulin secretion was increased by PHI. When arginine was used as a secretagogue, PHI (10 nmol/liter) potentiated secretion of insulin, glucagon, and somatostatin. Thus, PHI may take part in the regulation of the function of the pancreatic A, B, and D cells.


1984 ◽  
Vol 60 (6) ◽  
pp. 729-737
Author(s):  
Tomio TANESE ◽  
Manabu NARIMIYA ◽  
Haruo YAMADA ◽  
Ikuro MATSUBA ◽  
Akira TSURUOKA ◽  
...  

1980 ◽  
Vol 27 (Supplement) ◽  
pp. 95-102 ◽  
Author(s):  
MAKOTO OTSUKI ◽  
CHOITSU SAKAMOTO ◽  
HOSAI YUN ◽  
MITSUO MAEDA ◽  
SOICHIRO MORITA ◽  
...  

1990 ◽  
Vol 37 (6) ◽  
pp. 867-874 ◽  
Author(s):  
KOICHI KAWAI ◽  
SEIJI SUZUKI ◽  
KAZUE TAKANO ◽  
NAOMI HIZUKA ◽  
YASUKO WATANABE ◽  
...  

1989 ◽  
Vol 36 (4) ◽  
pp. 587-594 ◽  
Author(s):  
KOICHI KAWAI ◽  
HIDEHITO MUKAI ◽  
YUKINOBU CHIBA ◽  
HAJIME OHMORI ◽  
SEIJI SUZUKI ◽  
...  

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