scholarly journals Immunopharmacological Studies on TBX, a New Antiallergic Drug (1) Inhibitory Effects on Passive Cutaneous Anaphylaxis in Rats and Guinea Pigs

1988 ◽  
Vol 48 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Yukiyoshi YANAGIHARA ◽  
Hiroshi KASAI ◽  
Toshio KAWASHIMA ◽  
Takao SHIDA
Keyword(s):  
Guinea Pigs ◽  
Passive Cutaneous Anaphylaxis ◽  
Inhibitory Effects ◽  
Antiallergic Drug

scholarly journals Effect of AS-35, a novel antiallergic drug, on acetic acid-induced colitis in guinea pigs.

1993 ◽  
Vol 61 ◽  
pp. 331
Author(s):  
Shigeki Ohmura ◽  
Yoshinori Shiraishi ◽  
Noriko Takenawa ◽  
Seiji Kamiya ◽  
Yukiharu Ishida ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Guinea Pigs ◽  
Antiallergic Drug

PASSIVE CUTANEOUS ANAPHYLAXIS INDUCED IN GUINEA PIGS BY INSULINS AND THEIR COMPONENT CHAINS

1966 ◽  
Vol 44 (7) ◽  
pp. 989-996 ◽  
Author(s):  
S. Wilson ◽  
Marie A. Aprile ◽  
Louise Sasaki
Keyword(s):  
Guinea Pigs ◽  
Competitive Inhibition ◽  
The Other ◽  
Passive Cutaneous Anaphylaxis ◽  
Antigenic Determinants ◽  
Enzymic Digestion ◽  
Heterologous Antiserum ◽  
Wide Range ◽  
Homologous Antiserum

Small amounts of purified ox insulin and its component chains provoked passive cutaneous anaphylaxis (PCA) in guinea pigs previously injected intradermally with antiserum to ox insulin. Cod insulin and its chains also yielded a PCA reaction with antiserum to cod insulin, indicating that antibody-combining sites are located on both the A- and B-chains of insulin Enzymic digestion of the chain preparations essentially destroyed their ability to combine with anaphylactic antibodies, although the B-chain digests had some residual PCA reactivity.Ox and cod insulins gave positive PCA reactions with the heterologous antiserum but at higher levels than with the homologous antiserum, and none of the four chain preparations reacted with the heterologous antiserum. These results demonstrated differences between the antibody-combining sites on the chains of ox and cod insulins.Insulins from a wide range of species also yielded a PCA reaction with antisera to cod and ox insulins, suggesting that the different hormone preparations have certain antigenic determinants in common. Immunologic relationships between several insulins were derived from the competitive inhibition of one antiserum by the other when both were present in the same animal.

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