scholarly journals Alpha-Human Atrial Natriuretic Peptide (α-hANP) Prevents Pulmonary Edema Induced by Arachidonic Acid Treatment in Isolated Perfused Lung from Guinea Pig

1987 ◽  
Vol 44 (2) ◽  
pp. 211-214 ◽  
Author(s):  
Norio INOMATA ◽  
Norio OHNUMA ◽  
Mayumi FURUYA ◽  
Yujiro HAYASHI ◽  
Yasushi KANAI ◽  
...  
1993 ◽  
Vol 40 (3) ◽  
pp. 211-220 ◽  
Author(s):  
Paolo Di Nardo ◽  
Marco Pafi ◽  
Manuela Bartoli ◽  
Marilena Minieri ◽  
Fausta Bellegrandi ◽  
...  

1989 ◽  
Vol 67 (10) ◽  
pp. 1213-1218 ◽  
Author(s):  
W. Potvin ◽  
D. R. Varma

Atrial natriuretic peptide (ANP) produced concentration-dependent relaxation of isolated guinea pig tracheal chains contracted with histamine, serotonin, carbachol, and arachidonic acid. ANP was a full agonist. ANP was two-to three-fold less potent when compared with isoprenaline in relaxing histamine-, serotonin-, and arachidonic acid-contracted tracheal chains. However, ANP was 20-fold less potent than isoprenaline in relaxing carbachol-contracted tracheal chains. The relaxant potencies of isoprenaline and sodium nitroprusside were similar regardless of the agent used to induce the tone. ANP was less potent and efficacious than isoprenaline in inhibiting the serotonin-, histamine-, and carbachol-induced increases in pulmonary inflation pressure in pentobarbitone-anesthetized guinea pigs. Neither ANP nor isoprenaline inhibited the arachidonic acid-induced increase in pulmonary inflation pressure. ANP decreased and isoprenaline increased arterial pressure. The data suggest that ANP possesses limited bronchodilator activity especially in vivo.Key words: bronchodilatation, atrial natriuretic peptide, isoprenaline, arachidonic acid, bronchoconstrictors, guinea pig trachea, pulmonary inflation pressure.


1987 ◽  
Vol 43 ◽  
pp. 91
Author(s):  
Yujiro Hayashi ◽  
Mayumi Furuya ◽  
Fuyuki Iwasa ◽  
Norio Ohnuma ◽  
Tamayo Hatoh ◽  
...  

2016 ◽  
Vol 31 (2) ◽  
pp. 163-169 ◽  
Author(s):  
Takahiro Moriyama ◽  
Shintaro Hagihara ◽  
Toko Shiramomo ◽  
Misaki Nagaoka ◽  
Shohei Iwakawa ◽  
...  

1986 ◽  
Vol 70 (s13) ◽  
pp. 13P-13P ◽  
Author(s):  
A.M. Richards ◽  
J. Cleland ◽  
G. Tonolo ◽  
H. Dargie ◽  
G. McIntyre ◽  
...  

1992 ◽  
Vol 123 (4) ◽  
pp. 984-989 ◽  
Author(s):  
Masashi Akaike ◽  
Fuminobu Ishikura ◽  
Seiki Nagata ◽  
Kohji Kimura ◽  
Kunio Miyatake

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