scholarly journals Relationship between hypertensive response and brain kinin level in the rat injected intraventricularly with glandular kallikrein.

1987 ◽  
Vol 43 (2) ◽  
pp. 129-132 ◽  
Author(s):  
Kimio KARIYA ◽  
Aiko YAMAUCHI
Keyword(s):  
Glandular Kallikrein ◽  
Kinin Level

Temporal variations of glandular kallikrein, protein and amylase in mixed human saliva

1987 ◽  
Vol 32 (10) ◽  
pp. 757-759 ◽  
Author(s):  
Joyce W. Jenzano ◽  
C.K. Brown ◽  
Sally M. Mauriello
Keyword(s):  
Temporal Variations ◽  
Human Saliva ◽  
Glandular Kallikrein

Sensitive two-site immunoassays for measurement of the free and total forms of human glandular kallikrein 2 (hK2)

2002 ◽  
Vol 1 (1) ◽  
pp. 96
Author(s):  
Ville Väisänen ◽  
S. Eriksson ◽  
K. Ivaska ◽  
H. Lilja ◽  
K. Pettersson
Keyword(s):  
Glandular Kallikrein ◽  
Kallikrein 2

DISCRIMINATION OF MEN WITH PROSTATE CANCER FROM THOSE WITH BENIGN DISEASE BY MEASUREMENTS OF HUMAN GLANDULAR KALLIKREIN 2 (HK2) IN SERUM

2000 ◽  
Vol 163 (1) ◽  
pp. 311-316 ◽  
Author(s):  
CHARLOTTE BECKER ◽  
TIMO PIIRONEN ◽  
KIM PETTERSSON ◽  
THOMAS BJöRK ◽  
KIRK J. WOJNO ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Disease ◽  
Glandular Kallikrein ◽  
Kallikrein 2

Glandular Kallikrein, Renin and Angiotensin Converting Enzyme of Diabetic and Hypertensive Rats

1989 ◽  
pp. 443-448 ◽  
Author(s):  
Hiroshi Handa ◽  
Shoki Sakurama ◽  
Shoichi Nakagawa ◽  
Taro Yasukouchi ◽  
Wataru Sakamoto ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Glandular Kallikrein

Decreased concentrations of prostate-specific antigen and human glandular kallikrein 2 in malignant versus nonmalignant prostatic tissue

Urology ◽  
2000 ◽  
Vol 56 (3) ◽  
pp. 527-532 ◽  
Author(s):  
Angeliki Magklara ◽  
Andreas Scorilas ◽  
Carsten Stephan ◽  
Glen O Kristiansen ◽  
Steffen Hauptmann ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Prostatic Tissue ◽  
Glandular Kallikrein ◽  
Kallikrein 2

scholarly journals Human Glandular Kallikrein in Breast Milk, Amniotic Fluid, and Breast Cyst Fluid

1999 ◽  
Vol 45 (10) ◽  
pp. 1774-1780 ◽  
Author(s):  
Angeliki Magklara ◽  
Andreas Scorilas ◽  
Carlos López-Otín ◽  
Francisco Vizoso ◽  
Alvaro Ruibal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Amniotic Fluid ◽  
Biological Fluids ◽  
Cyst Fluid ◽  
Cystic Disease ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Glandular Kallikrein ◽  
Female Breast

Abstract Background: Human glandular kallikrein (hK2) belongs to the serine protease family of enzymes and has high sequence homology with prostate-specific antigen (PSA). The physiological role of hK2 has not as yet been determined, but there is evidence that it can regulate the proteolytic activity of PSA through processing and activating pro-PSA, an inactive precursor. Thus, it is conceivable that these two secreted proteins may coexist in biological fluids. Currently, hK2 is considered an androgen-regulated and prostate-specific protein. Recently, it has been demonstrated that hK2 is expressed in the breast cancer cell line T-47D after stimulation by steroid hormones, and we reported that hK2 can be detected in a subset of breast tumor extracts. These data suggest that hK2 may be expressed in tissues other than the prostate, such as those in which PSA has already been detected. Because hK2 is a secreted protein, it may be present in various biological fluids. Methods: We analyzed milk samples from lactating women, amniotic fluid from pregnant women, and breast cyst fluid from patients with gross breast cystic disease, using a highly sensitive and specific immunoassay for hK2. Results: hK2 was present in all three biological fluids. We suggest that the female breast may produce hK2 and provide evidence that hK2 may have value as an additional marker for the discrimination between type I and type II breast cysts. Conclusions: The female breast produces hK2 in addition to PSA. More studies are necessary to establish the role of this kallikrein in nondiseased breast, gross breast cystic disease, and breast cancer.

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