scholarly journals Involvement of cyclic AMP in the positive inotropic effect of OPC-8212, a new cardiotonic agent, on the canine ventricular muscle.

1984 ◽  
Vol 36 (3) ◽  
pp. 379-388 ◽  
Author(s):  
Teruyuki YANAGISAWA ◽  
Masao ENDOH ◽  
Norio TAIRA
Keyword(s):  
Cyclic Amp ◽  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Ventricular Muscle ◽  
Cardiotonic Agent

Cyclic AMP and the positive inotropic effect of norepinephrine and phenylephrine

1977 ◽  
Vol 55 (2) ◽  
pp. 279-287 ◽  
Author(s):  
T. T. Martinez ◽  
J. H. McNeill
Keyword(s):  
Cyclic Amp ◽  
Cell Membrane ◽  
Time Course ◽  
Positive Inotropic Effect ◽  
Contractile Response ◽  
Contractile Force ◽  
Time Response ◽  
Inotropic Effect ◽  
Chronotropic Response ◽  
Right Atria

Time-response studies of the effects of norepinephrine and phenylephrine revealed that both agonists caused an increase in cyclic AMP levels before increases in contractile force in either the electrically stimulated left atria or spontaneously beating right atria of the rat. Norepinephrine caused a nearly sixfold increase in cyclic AMP, whereas phenylephrine produced only a 50% increase in the nucleotide. Pretreatment with reserpine did not affect the norepinephrine cyclic AMP response; however, the phenylephrine cyclic AMP response was abolished. Reserpine pretreatment did not significantly affect the contractile responses of either amine. In the presence of propranolol, norepinephrine was found to have the ability to produce an increase in contractile force in which cyclic AMP was apparently not involved. The time course of the contractile response induced by adrenergic amines was found to be remarkably influenced by the chronotropic response in spontaneously beating preparations while the cyclic AMP response was not greatly affected. This difference in the contractile response may be due to the ability of the chronotropic response to influence the flux of calcium through the cell membrane.

scholarly journals Adenosine inhibits the positive inotropic effect of 3-isobutyl-1-methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP

1988 ◽  
Vol 93 (4) ◽  
pp. 729-738 ◽  
Author(s):  
Michael Böhm ◽  
Reinhard Brückner ◽  
Joachim Neumann ◽  
Monika Nose ◽  
Wilhelm Schmitz ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Cyclic Gmp ◽  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Papillary Muscles
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