scholarly journals Heterogeneous distribution of the cytochrome P-450 monooxygenase system in rat liver lobes.

1982 ◽  
Vol 32 (6) ◽  
pp. 999-1011 ◽  
Author(s):  
Takashi MATSUBARA ◽  
Akira TOUCHI ◽  
Ayako OGAWA
Keyword(s):  
Rat Liver ◽  
Monooxygenase System ◽  
Heterogeneous Distribution ◽  
Cytochrome P 450

scholarly journals Postnatal development and sublobular distribution of cytochrome P-450 in rat liver: a microphotometric study.

1993 ◽  
Vol 41 (3) ◽  
pp. 397-400 ◽  
Author(s):  
J Watanabe ◽  
Y Asaka ◽  
S Kanamura
Keyword(s):  
Postnatal Development ◽  
Rat Liver ◽  
Perinatal Period ◽  
Postnatal Growth ◽  
Male Rats ◽  
Heterogeneous Distribution ◽  
Liver Lobule ◽  
Subsequent Period ◽  
The Difference ◽  
Cytochrome P 450

To study the process of expression of cytochrome P-450 (P-450) in hepatocytes during development, we measured microphotometrically the P-450 content in periportal and perivenular hepatocytes of male rats during peri- and postnatal growth. From Day 19 of gestation to Day 5 after birth, P-450 content in both periportal and perivenular hepatocytes increased markedly (periportal 1046%; perivenular 819%). The content in periportal hepatocytes remained unchanged from 5 to 20 days of age, and increased slightly (24%) from 20 to 45 days of age. However, the content in perivenular hepatocytes increased progressively (105%) between 5 and 45 days of age. The difference in P-450 content became apparent between periportal and perivenular hepatocytes after 7 days of age. The content in periportal or perivenular hepatocytes reached the adult level at 45 days of age. Therefore, the perinatal period is the time at which a marked increase in P-450 occurs in hepatocytes throughout the liver lobule. The subsequent period before weaning is the time at which the sublobular heterogeneous distribution of P-450 appears. The period after weaning is the time at which a slight increase in P-450 content in periportal hepatocytes and a marked increase in the enzyme in perivenular hepatocytes takes place.

THE EFFECT OF VITAMIN E ON THE BIOCHEMICAL PARAMETERS IN THE EXPERIMENT

2020 ◽  
Vol 93 (1) ◽  
pp. 103-105
Author(s):  
I. Shukurov ◽  
◽  
Ch. Khayrullayev ◽  
M. Gulomova ◽  
F. Umurov
Keyword(s):  
Acute Pancreatitis ◽  
Cytochrome P450 ◽  
Vitamin E ◽  
Rat Liver ◽  
Biochemical Parameters ◽  
Microsomal Fraction ◽  
Monooxygenase System ◽  
Experimental Acute Pancreatitis ◽  
Liver Cytochrome ◽  
Cytochrome P 450

The effect of vitamin E on rat liver cytochrome P-450 in experimental acute pancreatitis (AP) was studied. The animals were divided into 4 groups. The obtained data were compared with the indicators of the 1–st group (intact). During the experiment, the development of AP showed a decrease in the content of cytochrome P450 in the microsomal fraction. The administration of vitamin E to animals of the 4th group led to an increase in the content of cytochrome P-450, strengthening the protection of the liver, the abolition of inhibition of the monooxygenase system of the liver.

Induction of Cytochrome P-450-linked Monooxygenase System in Rat Liver Microsomes by Xiao-Chaihu-Tang

1996 ◽  
Vol 24 (02) ◽  
pp. 143-151 ◽  
Author(s):  
Taira Ohnishi ◽  
Hirohito Yoneyama ◽  
Tatushichiro Hamamoto ◽  
Toshihiko Ishida ◽  
Jirou Takahara ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
The Other ◽  
Female Rats ◽  
Male Rats ◽  
Monooxygenase System ◽  
Rat Liver Microsomes ◽  
Female Rat ◽  
Metabolic Rates ◽  
Cytochrome P 450

The administration of Xiao-Chaihu- Tang (TJ-9) for 2 weeks induced a 25% increase in the content of cytochrome P-450 in female rat liver microsomes, while the content in male rats remained unchanged. The enzymatic activities toward various xenobiotics were stimulated in female rats, the levels being in the range of 125-250% of those in the control rats. Among these xenobiotics, the metabolic rates for substrates of cytochrome P-450 2El were significantly enhanced in female rats. On the other hand, the activities toward various xenobiotics in male rats were unchanged. When 3-methylcholanthrene was given to rats for a week, the augmentation of cytochrome P-450 content and the stimulation ofxenobiotic metabolism were observed. However, co-administration ofTJ-9 did not alter the effect of 3-methylcholanthrene described above.

Effects of Cold Preservation and Reperfusion on Microsomal Cytochrome P-450-Linked Monooxygenase System of the Rat Liver

1996 ◽  
Vol 61 (2) ◽  
pp. 361-366 ◽  
Author(s):  
Kunihiko Izuishi ◽  
Yoshiyuki Ichikawa ◽  
Mohammad Akram Hossain ◽  
Takashi Maeba ◽  
Hajime Maeta ◽  
...  
Keyword(s):  
Rat Liver ◽  
Monooxygenase System ◽  
Cold Preservation ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450
Sign in / Sign up

Export Citation Format

Share Document