scholarly journals EFFECTS OF PHTHALAZINOL, EG 626, ON MEMBRANE AND MECHANICAL PROPERTIES OF SMOOTH MUSCLE CELLS OF RABBIT MAIN PULMONARY ARTERY AND SUPERIOR MESENTERIC ARTERY

1979 ◽  
Vol 29 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Hikaru SUZUKI ◽  
Yushi ITO ◽  
Hirosi KURIYAMA ◽  
Takio SHIMAMOTO
Keyword(s):  
Mechanical Properties ◽  
Smooth Muscle ◽  
Pulmonary Artery ◽  
Smooth Muscle Cells ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Main Pulmonary Artery ◽  
Muscle Cells

Isolation and culture of rat superior mesenteric artery smooth muscle cells

1993 ◽  
Vol 29 (2) ◽  
pp. 135-139 ◽  
Author(s):  
Paul G. McGuire ◽  
Helen M. Walker-Caprioglio ◽  
Sally A. Little ◽  
Linda J. McGuffee
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Muscle Cells

Membrane properties of smooth muscle cells in pulmonary hypertensive rats

1982 ◽  
Vol 242 (5) ◽  
pp. H907-H915 ◽  
Author(s):  
H. Suzuki ◽  
B. M. Twarog
Keyword(s):  
Smooth Muscle ◽  
Membrane Potential ◽  
Pulmonary Artery ◽  
Smooth Muscle Cells ◽  
Main Pulmonary Artery ◽  
Fold Increase ◽  
Muscle Cells ◽  
Membrane Properties ◽  
Resting Membrane Potential ◽  
Chronic Pulmonary Hypertension

The membrane properties of smooth muscle cells in rat main pulmonary artery (MPA) and small pulmonary artery (SPA) were investigated during chronic normobaric hypoxia and after monocrotaline injection. As chronic pulmonary hypertension developed, pronounced differences between MPA and SPA were observed. These findings may shed light on mechanisms of smooth muscle hypertrophy. 1) The resting membrane potential of smooth muscle in MPA became less negative than the normal (depolarized), whereas the resting membrane potential of smooth muscle in SPA became more negative (hyperpolarized). 2) In MPA, both the length and time constants diminished. 3) In MPA, the maximum membrane depolarization produced by a 10-fold increase in extracellular [K+] decreased. 4) In SPA, the depolarization observed in K+-free solution was more rapid and greater in amplitude, and the transient hyperpolarization following restoration of K+-containing solution increased. 5) In SPA, initial and sustained depolarization evoked by Na+-deficient solutions were increased. 6) Depolarization in MPA was due to increased membrane permeability, perhaps to Cl-, whereas hyperpolarization in SPA could be attributed to increased activity of an electrogenic Na+-K+ pump.

Membrane properties of smooth muscle cells in pulmonary arteries of the rat

1982 ◽  
Vol 242 (5) ◽  
pp. H900-H906 ◽  
Author(s):  
H. Suzuki ◽  
B. M. Twarog
Keyword(s):  
Smooth Muscle ◽  
Membrane Potential ◽  
Pulmonary Artery ◽  
Smooth Muscle Cells ◽  
Main Pulmonary Artery ◽  
Pulmonary Arteries ◽  
Outward Current ◽  
Muscle Cells ◽  
Membrane Properties ◽  
Similar Degree

Electrical properties of the membrane of smooth muscle cells in the rat main pulmonary artery (MPA) and a small pulmonary artery (SPA) were compared. MPA and SPA differed in several important respects, suggesting characteristic quantitative and qualitative differences in membrane properties. 1) Resting membrane potentials were similar in both (MPA 52.2 +/- 1.3 mV; SPA 51.5 +/- 1.7 mV). The cells displayed no spontaneous electrical activity. The muscle layers in both MPA and SPA showed cablelike properties; a graded local response to outward current pulses was observed, but no action potentials were evoked. 2) Tetraethylammonium chloride (TEA, 1-5 mM) depolarized, increased membrane resistance, and suppressed rectification in MPA. TEA strongly depolarized SPA and contraction ensued. 3) The maximum membrane depolarization produced by a 10-fold increase in extracellular [K+] was 48 mV in MPA and 47 mV in SPA. In K+-free solution gradual depolarization was observed in SPA, but the membrane potential in MPA was not modified. Restoration of K+-containing solution produced equivalent hyperpolarization in both tissues, indicating a similar degree of stimulation of electrogenic Na+-K+ pumping. 4) A Na+-deficient solution did not affect the membrane potential in MPA but depolarized SPA.

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