scholarly journals Studies on Cyclic Nucleotides in the Adrenal Gland VII. Cyclic AMP Systems in the Adrenal Medulla in Vivo

1978 ◽  
Vol 28 (4) ◽  
pp. 597-605 ◽  
Author(s):  
Sumio Shima ◽  
Yoshiko Kawashima ◽  
Masanao Hirai
Keyword(s):  
Cyclic Amp ◽  
Adrenal Gland ◽  
Adrenal Medulla ◽  
Cyclic Nucleotides

Studies on cyclic nucleotides in the adrenal gland : VI adenyl and guanyl cyclase in the adrenal medulla

1976 ◽  
Vol 8 (6) ◽  
pp. 557-563 ◽  
Author(s):  
Sumio Shima ◽  
Yoshtko Kawashima ◽  
Masanao Hirai ◽  
Satoshi Ihara ◽  
Hiroshi Kouyama
Keyword(s):  
Adrenal Gland ◽  
Adrenal Medulla ◽  
Cyclic Nucleotides

scholarly journals Studies on cyclic nucleotides in the adrenal gland VIII : Adenyl cyclase in the adrenal medulla

1976 ◽  
Vol 26 ◽  
pp. 111
Author(s):  
Sumio Shima ◽  
Yoshiko Kawashima ◽  
Masanao Hirai ◽  
Satoshi Ihara ◽  
Hiroshi Kouyama
Keyword(s):  
Adrenal Gland ◽  
Adrenal Medulla ◽  
Cyclic Nucleotides ◽  
Adenyl Cyclase

ALTERATIONS IN CYCLIC NUCLEOTIDES IN DOGS AFTER TRIIODOTHYRONINE

1975 ◽  
Vol 79 (1) ◽  
pp. 66-75 ◽  
Author(s):  
J. A. Fernandez-Pol ◽  
Marguerite T. Hays
Keyword(s):  
Adipose Tissue ◽  
Cyclic Amp ◽  
Cyclic Gmp ◽  
Cyclic Nucleotides ◽  
Time Lag ◽  
The Other ◽  
Experimental Procedure ◽  
Single Intravenous Injection ◽  
Converse Relation

ABSTRACT The effects of triiodothyronine (T3) on plasma and tissue levels (liver, adipose tissue, muscle) of adenosine 3′,5′-monophosphate (cyclic AMP) and guanosine 3′,5′-monophosphate (cyclic GMP) were determined in Mongrel dogs. Plasma cyclic AMP increased to a mean plateau value 165 % greater than control values in response to a single intravenous injection of T3 (100–200 μg/kg body weight). This treatment resulted in no increase in plasma cyclic GMP. In liver, cyclic AMP concentration decreased 54 %, while cyclic GMP increased 137 %. Adipose tissue cyclic AMP levels decreased in control animals during the experimental procedure. On the other hand, animals given T3 had stable or (in one case) increasing adipose tissue cyclic AMP levels. Hence, T3, actually maintained higher levels than that expected, in comparison to the control. Cyclic GMP levels in adipose tissue were not affected by T3. Cyclic AMP and cyclic GMP were unchanged in muscle. In all cases, a time lag occurred (30–40 min) between administration of T3 and subsequent alterations in cyclic nucleotide levels. It was concluded that T3 is capable of altering concentrations of cyclic AMP and cyclic GMP in vivo and that cyclic AMP and cyclic GMP patterns of response are completely different. In liver, a converse relation of the two nucleotides is present. These findings are compatible with the hypothesis that some of T3's action may be explained by its effects upon either cyclic AMP or cyclic GMP.

scholarly journals STUDIES ON CYCLIC NUCLEOTIDES IN THE ADRENAL GLAND V. ADENYLATE CYCLASE IN THE ADRENAL MEDULLA

1976 ◽  
Vol 26 (6) ◽  
pp. 711-717 ◽  
Author(s):  
Sumio SHIMA ◽  
Yoshiko KAWASHIMA ◽  
Masanao HIRAI ◽  
Hiroshi KOUYAMA
Keyword(s):  
Adrenal Gland ◽  
Adenylate Cyclase ◽  
Adrenal Medulla ◽  
Cyclic Nucleotides

MODIFICATION OF MYOMETRIAL ACTIVITY IN VIVO BY ADMINISTRATION OF CYCLIC NUCLEOTIDES AND THEOPHYLLINE TO THE PREGNANT RAT

1975 ◽  
Vol 66 (3) ◽  
pp. 339-347 ◽  
Author(s):  
J. W. BUCKLE ◽  
P. W. NATHANIELSZ
Keyword(s):  
Cyclic Amp ◽  
Cyclic Gmp ◽  
Cyclic Nucleotides ◽  
Dibutyryl Cyclic Amp ◽  
Short Term ◽  
Pregnant Rats ◽  
Pregnant Rat ◽  
Uterine Activity ◽  
Prostaglandin F

SUMMARY Myometrial activity was recorded in vivo in unrestrained pregnant rats from day 19 of gestation using radiotelemetry. The effects of short-term infusions of theophylline, dibutyryl cyclic AMP and 8-bromo-cyclic GMP were investigated. All three compounds caused a decrease in oxytocin-induced, prostaglandin F2α-induced and spontaneous uterine activity. After cessation of the infusion of these compounds uterine activity returned to near pre-infusion levels within approximately 15 min in most animals. The possible roles of cyclic nucleotides in the control of myometrial contraction are discussed in the light of these observations.

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