scholarly journals AN EXPERIMENTAL STUDY OF THE β-RECEPTOR BLOCKING AGENTS ON THE CARDIAC PERFORMANCE IN DOGS

1970 ◽  
Vol 20 (4) ◽  
pp. 467-472
Author(s):  
N. SINGH ◽  
R.K. SRIVASTAVA ◽  
V.K. KULSHRESTHA ◽  
J.N. SINHA ◽  
R.P. KOHLI ◽  
...  
Keyword(s):  
Experimental Study ◽  
Cardiac Performance ◽  
Receptor Blocking ◽  
Blocking Agents ◽  
Β Receptor

β-Receptor-Blocking Agents May Reverse or Prevent Diuretic-Induced Increases in Serum Low-Density Lipoprotein Cholesterol

1981 ◽  
Vol 61 (s7) ◽  
pp. 437s-439s ◽  
Author(s):  
A. Meier ◽  
H. Schiffl ◽  
P. Weidmann ◽  
R. Mordasini ◽  
W. Riesen ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Receptor Blocking ◽  
Blocking Agents ◽  
Group I ◽  
Β Blocker ◽  
Β Receptor

1. The effect of treatment with a thiazide-like diuretic alone or combined with a β-adrenoceptor blocker on serum lipoproteins was investigated in 35 patients with essential hypertension. 2. In group I (18 patients), serum low-density lipoprotein cholesterol was increased (P < 0.001) during monotherapy with chlorthalidone (100 mg/day) but not during combined chlorthalidone-β-blocker therapy. 3. This tendency was similar in subgroups studied with an inverse sequence of drug administration. In subgroup IA (11 men), a 22% increase (P < 0.01) in low-density lipoprotein cholesterol after 6 weeks of chlorthalidone was reversed after use of a β-blocker as well as chlorthalidone; in subgroup IB (five men, two post-menopausal women), low-density lipoprotein cholesterol was increased by 41% (P < 0.05) above placebo values 6 weeks after withdrawal of the β-blocker from combination therapy. 4. In group II (18 men), low-density lipoprotein cholesterol was increased by 13% (P < 0.025) after 4 weeks of monotherapy with clopamide (5 mg/day) but restored to control levels 4 weeks after addition of pindolol (10 mg/day). 5. No significant changes occurred during any treatment phase in high-density lipoprotein cholesterol. 6. Certain β-receptor blocking agents may prevent or reverse diuretic-induced increases in serum low-density lipoprotein cholesterol.

A comparison of the cardiovascular actions of four adrenergic β-receptor blocking agents in resting, conscious dogs

1971 ◽  
Vol 82 (3) ◽  
pp. 338-351 ◽  
Author(s):  
Mario Bergamaschi ◽  
Robin G. Shanks ◽  
Anna M. Caravaggi ◽  
Virginio Mandelli
Keyword(s):  
Conscious Dogs ◽  
Receptor Blocking ◽  
Blocking Agents ◽  
Cardiovascular Actions ◽  
Β Receptor

Effect of β-Receptor-Blocking Agents on Cardiovascular Structural Changes in Spontaneous and Noradrenaline-Induced Hypertension in Rats

1980 ◽  
Vol 59 (s6) ◽  
pp. 457s-460s ◽  
Author(s):  
Yukio Yamori ◽  
R. C. Tarazi ◽  
Akira Ooshima
Keyword(s):  
Blood Pressure ◽  
Protein Synthesis ◽  
Structural Changes ◽  
Cardiovascular Response ◽  
Left Ventricular ◽  
Spontaneously Hypertensive ◽  
Receptor Blocking ◽  
Blocking Agents ◽  
Collagen Protein ◽  
Β Receptor

1. Continuous intravenous noradrenaline infusion for 1 week into rats by osmotic minipumps significantly increased blood pressure and left ventricular weight. 2. Concomitant α-receptor-blockade infusion significantly lowered blood pressure and the aortic weight without significant reduction in left ventricular weight. 3. Two β-receptor-blocking agents in noradrenaline-infused rats normalized left ventricular weight and significantly reduced the aortic weight, although blood pressure was still higher than control non-infused rats. 4. In 7-week-old spontaneously hypertensive rats, propranolol (perorally for 2 weeks) did not lower blood pressure but reduced significantly cardiovascular protein synthesis ([14C]lysine and [3H]uridine incorporation into non-collagen protein and RNA respectively) in both left ventricle and aorta. This effect was in contrast to hydrallazine, which normalized blood pressure but did not reduce cardiovascular protein synthesis. 5. Results suggest that β-receptors play a modulating role in the structural cardiovascular response to blood pressure.

scholarly journals Actions of β-receptor blocking agents on adrenergic neurons.

1980 ◽  
Vol 30 ◽  
pp. 21
Author(s):  
Yoshimi Misu ◽  
Masayoshi Kaiho ◽  
Kazuko Qgawa ◽  
Takao Kubo
Keyword(s):  
Adrenergic Neurons ◽  
Receptor Blocking ◽  
Blocking Agents ◽  
Β Receptor

Adrenergic mechanisms in infection. III. α- and β-receptor blocking agents in treatment

1977 ◽  
Vol 30 (8) ◽  
pp. 1285-1288 ◽  
Author(s):  
I M Smith ◽  
L R Kennedy ◽  
M H Regné-Karlsson ◽  
V L Johnson ◽  
L F Burmeister
Keyword(s):  
Receptor Blocking ◽  
Adrenergic Mechanisms ◽  
Blocking Agents ◽  
Β Receptor
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