scholarly journals INHIBITION OF DRUG-METABOLIZING ENZYMES OF LIVER MICROSOMES BY HYDRAZINE DERIVATIVES IN RELATION TO THEIR LIPID SOLUBILITY

1969 ◽  
Vol 19 (2) ◽  
pp. 315-322 ◽  
Author(s):  
RYUIGHI KATO ◽  
AKIRA TAKANAKA ◽  
HATSUE SHOJI
Keyword(s):  
Liver Microsomes ◽  
Lipid Solubility ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Hydrazine Derivatives

Use of SWATH-MS to relatively quantify the expression of hepatic drug metabolizing enzymes in human liver microsomes using a label-free approach

2018 ◽  
Vol 33 (1) ◽  
pp. S57-S58
Author(s):  
Rohitash Jamwal ◽  
Benjamin J. Barlock ◽  
Sravani Adusumalli ◽  
Ken Ogasawara ◽  
Brigitte L. Simons ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Drug Metabolizing Enzymes ◽  
Label Free ◽  
Metabolizing Enzymes ◽  
Hepatic Drug

The Effect of Dietary Sulfur-Containing Amino Acids on the Activity of Drug-Metabolizing Enzymes in Rat-Liver Microsomes

1979 ◽  
Vol 109 (5) ◽  
pp. 864-871 ◽  
Author(s):  
Jacques Magdalou ◽  
Daniele Steimetz ◽  
Anne-Marie Batt ◽  
Bernard Poullain ◽  
Gérard Siest ◽  
...  
Keyword(s):  
Amino Acids ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Drug Metabolizing Enzymes ◽  
Rat Liver Microsomes ◽  
Metabolizing Enzymes ◽  
Sulfur Containing

Induction of drug-metabolizing enzymes of rat liver by derivatives of coumarin

1970 ◽  
Vol 48 (4) ◽  
pp. 232-240 ◽  
Author(s):  
George Feuer
Keyword(s):  
Lipid Solubility ◽  
Induction Effect ◽  
Drug Metabolizing Enzymes ◽  
Test Compound ◽  
Hydroxylase Activity ◽  
Metabolizing Enzymes ◽  
Oral Doses ◽  
Derivatives Of ◽  
Related Compounds ◽  
Enzyme Inducers

The ability of coumarin and 35 structurally related compounds to induce coumarin 3-hydroxylase was examined in the liver of the rat. After seven daily oral doses of 1 mmole/kg of the test compound, the hydroxylase activity with coumarin or 4-methylcoumarin as substrate was increased 13- to 14-fold by 8-(2″-butenyloxy-3″-methyl)-furo-(2′:3′–6:7) coumarin; 4- to 8-fold by 4-methylcoumarin; 6-fold by 6-acetyl-4,8-dimethyl-7-hydroxycoumarin; 2- to 5-fold by 7,8-dihydroxy-4-methylcoumarin; 2- to 3-fold by 6,7-dihydroxy-4-methylcoumarin, 7-hydroxy-4-methylcoumarin, 4,8-dimethyl-7-hydroxycoumarin, 3-isopropyl-7-methoxy-4-methyl coumarin, 3-chloro-7-methoxy-4-methylcoumarin, and 3-carboxycoumarin. Nearly all enzyme inducers contained the 4-methyl substituent. 4-Methylcoumarin and 6,7-dihydroxy-4-methyl coumarin elicited a greater induction on the hydroxylation of 4-methylcoumarin than on that of coumarin. The other coumarin derivatives brought about no consistently greater effect on either hydroxylase. No correlation was found between the induction effect and the lipid solubility of the inducer. 4-Methylcoumarin exerted a greater induction effect on coumarin 3-hy droxylase than on nitroanisole or codeine demethylase and hexobarbitone or butylated hydroxy toluene oxidases. Other known enzyme inducers (hexobarbitone, 17-methyltestosterone, and 20-methylcholanthrene) also increased hydroxylase activity in a manner comparable to that of 4-methylcoumarin.

Metabolism of Chamaechromone In Vitro with Human Liver Microsomes and Recombinant Human Drug-Metabolizing Enzymes

Planta Medica ◽  
2014 ◽  
Vol 80 (06) ◽  
pp. 493-497 ◽  
Author(s):  
Yan Lou ◽  
Haihong Hu ◽  
Yunqing Qiu ◽  
Jinqi Zheng ◽  
Linrun Wang ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes
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