scholarly journals Preventive effect of KZ-1026 on acute liver injury induced by CCl4 in rats: Histochemical, enzyme-histochemical and ultrastructural studies.

1989 ◽  
Vol 93 (1) ◽  
pp. 17-27 ◽  
Author(s):  
Masahiko KOBAYASHI ◽  
Takeo TAKAHASHI ◽  
Kazuhiro TAGUCHI ◽  
Yukio HIRAYAMA ◽  
Sonoko TSUCHIDA ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Preventive Effect ◽  
Ultrastructural Studies

Mechanism of the Protective Effects of Sumac Gall Extract and Gallic Acid on the Progression of CCl4-induced Acute Liver Injury in Rats

1998 ◽  
Vol 26 (03n04) ◽  
pp. 333-341 ◽  
Author(s):  
Shigeyuki Kanai ◽  
Hideyuki Okano
Keyword(s):  
Superoxide Dismutase ◽  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Gallic Acid ◽  
Cell Membranes ◽  
Acute Liver Injury ◽  
Radical Scavenging ◽  
Protective Effects ◽  
Preventive Effect

To examine the mechanism of the preventive effect of tannins on the progression of carbon tetrachloride (CCl4)-induced acute liver injury in rats, sumac gall (SG) extract and gallic acid (GA) were used as substitutes for crude tannins, because SG is a kind of Chinese traditional medicinal herb containing large amounts of various tannins, and GA is one of the major constituents of SG. The protective effect of oral (p.o.) and intraperitoneal (i.p.) administration of each substance on progression of CCl4-induced hepatitis was investigated in rats. Speculating that the superoxide dismutase (SOD)-like activities (O2 radical-scavenging activities) and/or protective effects of these substances on cell membranes might play a key role in the mechanism opposing the progression of CCl4-induced hepatitis, the O2 radical-scavenging activities in liver cells and serum in rats were monitored. Both substances significantly prevented the progression of acute liver injury with both p.o. and i.p. administration. These findings suggest that the mechanism for this prevention might be due mainly to the protective effect of these substances on cell membranes rather than O2 radical-scavenging activities.

scholarly journals Preventive Effect of Lactobacillus Plantarum HFY15 on Oxidative Damage and Acute Liver Injury Induced by Carbon Tetrachloride (CCl 4 ) in Mice

2021 ◽  
Author(s):  
Xingyao Long ◽  
Pan Wang ◽  
Yujing Zhou ◽  
Qiang Wang ◽  
Lixuan Ren ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Oxidative Damage ◽  
Lactobacillus Plantarum ◽  
Acute Liver Injury ◽  
Animal Experiments ◽  
B Cell Lymphoma ◽  
Related Factor ◽  
Preventive Effect ◽  
Antioxidant Genes

Abstract BackgroundCarbon tetrachloride (CCl4) is a widely used hepatic toxin that causes acute liver injury through pathological mechanisms such as oxidative stress, inflammation, and apoptosis. In this experiment, mice were treated with Lactobacillus plantarum (LP) HFY15, silymarin, and Lactobacillus delbruechii subsp. bulgaricus (LDSB) for two weeks, and intraperitoneal injection of CCl4-induced acute liver injury to study the preventive effect of LP-HFY on CCl4-induced acute liver injury, especially in oxidative damage. ResultsThe survival rate of LP-HFY15 in artificial gastric juice is 92.1%, and the growth efficiency in bile salt is 78.8%. Animal experiments show that LP-HFY15 reduces the liver index of mice, reduces the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the content of triglycerides (TG), malondialdehyde (MDA) and reactive oxygen species (ROS) in the serum of mice. LP-HFY15 also increased the antioxidant genes, such as nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase (HO-1), NAD(P)H:quinone oxidoreductase (NQO1), and increases the activity of superoxide dismutation (SOD), catalase (CAT), and glutathione (GSH) in the serum and gene level. At the same time, LP-HFY15 reduced the levels of cytokines IL-6, TNF-α, and IFN-γ in the serum and liver, increased antiapoptosis gene B-cell lymphoma-2 (Bcl-2) expression in the liver of mice, and inhibit the expression of proapoptotic genes Bcl-2-associated X (Bax) and Caspase-3. ConclusionsCompared with LDSB, LP-HFY15 has a greater alleviating effect on the liver injury caused by CCl4. These findings demonstrate that LP-HFY15 has great potential and research value in the future as a food supplement for preventing acute liver damage.

Preventive effect of Ganoderma amboinense on acetaminophen-induced acute liver injury

Phytomedicine ◽  
2008 ◽  
Vol 15 (11) ◽  
pp. 946-950 ◽  
Author(s):  
Cheng-chin Hsu ◽  
Ko-yen Lin ◽  
Zhi-hong Wang ◽  
Wea-lung Lin ◽  
Mei-chin Yin
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Preventive Effect

Preventive effect of cyclosporin A on experimentally induced acute liver injury in rats

2008 ◽  
Vol 17 (2) ◽  
pp. 107-114 ◽  
Author(s):  
Shuji Wasaki ◽  
Isao Sakaida ◽  
Koichi Uchida ◽  
Teruaki Kimura ◽  
Kozo Kayano ◽  
...  
Keyword(s):  
Liver Injury ◽  
Cyclosporin A ◽  
Acute Liver Injury ◽  
Preventive Effect ◽  
Experimentally Induced

Aloe-Emodin Quinone Pretreatment Reduces Acute Liver Injury Induced by Carbon Tetrachloride

2000 ◽  
Vol 87 (5) ◽  
pp. 229-233 ◽  
Author(s):  
Beatrice Arosio ◽  
Nicoletta Gagliano ◽  
Lorena Maria Pia Fusaro ◽  
Luciano Parmeggiani ◽  
Jacopo Tagliabue ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Aloe Emodin
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