scholarly journals Effects of ethylcholine mustard aziridinium ion (AF64A) administered intraperitoneally on cholinergic nerves in rat brain.

1988 ◽  
Vol 92 (6) ◽  
pp. 349-358
Author(s):  
Hideaki NISHIO ◽  
Arihiro NODA ◽  
Yasunori MORIO ◽  
Osamu YAGASAKI
Keyword(s):  
Rat Brain ◽  
Cholinergic Nerves ◽  
Aziridinium Ion ◽  
Ethylcholine Mustard Aziridinium Ion

scholarly journals Changes in GABAa and GABAb receptors in rat striatum microinjected with ethylcholine mustard aziridinium ion, AF64A.

1999 ◽  
Vol 79 ◽  
pp. 145
Author(s):  
Yasushi Ikarashi ◽  
Mitsutoshi Yuzurihara ◽  
Akira Takahashi ◽  
Hirohisa Ishimaru ◽  
Takemi Shiobara ◽  
...  
Keyword(s):  
Gabab Receptors ◽  
Rat Striatum ◽  
Aziridinium Ion ◽  
Gabaa And Gabab Receptors ◽  
Ethylcholine Mustard Aziridinium Ion

Is ethylcholine mustard aziridinium ion a specific cholinergic neurotoxin?

Neuroscience ◽  
1987 ◽  
Vol 22 (1) ◽  
pp. 215-224 ◽  
Author(s):  
S.R. McGurk ◽  
S.L. Hartgraves ◽  
P.H. Kelly ◽  
M.N. Gordon ◽  
L.L. Butcher
Keyword(s):  
Aziridinium Ion ◽  
Ethylcholine Mustard Aziridinium Ion

scholarly journals An Attempt to Produce Cholinergic Hypofunction in Rat Brain using Choline Mustard Aziridinium Ion: Neurochemical and Histological Parameters

1986 ◽  
Vol 13 (S4) ◽  
pp. 517-520 ◽  
Author(s):  
E.H. Colhoun ◽  
L.A. Myles ◽  
R.J. Rylett
Keyword(s):  
Rat Brain ◽  
Tissue Damage ◽  
Dorsal Hippocampus ◽  
Memory Loss ◽  
Medial Septum ◽  
Aziridinium Ion ◽  
Early Memory ◽  
Medial Septal Nucleus ◽  
Specific Tissue ◽  
Cholinergic Hypofunction

Abstract:Deficiencies in cholinergic nerve function have been clearly documented in patients with Alzheimer's disease. The lack of this neurotransmitter may be responsible for early memory loss in patients with the disease. Choline mustard Az ion has been used in our laboratory to produce cholinergic hypofunction in rat brain. Injections of the compound into the medial septal nucleus and dorsal hippocampus produced tissue lesions. The lesions were dose and time-dependent. Lesions produced in the medial septum resulted in transmitter depression in the hippocampus. These results suggest non-specific tissue damage because 5-HT levels were lower than normal. Other strategies for getting choline mustard Az ion into rat brain are being investigated to circumvent the apparent ability of this compound and other nitrogen mustard analogs of choline to produce non-specific tissue damage when injected directly into brain tissue.

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