scholarly journals Inhibitory effect of AD-1590, a non-steroidal anti-inflammatory drug, on allergic inflammation in mice and rats.

1988 ◽  
Vol 92 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Hideo NAKAMURA ◽  
Satoru MOTOYOSHI ◽  
Katsumi ISHII ◽  
Toshiaki KADOKAWA
Keyword(s):  
Allergic Inflammation ◽  
Inhibitory Effect ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
P. Skopiński ◽  
B. J. Bałan ◽  
J. Kocik ◽  
R. Zdanowski ◽  
S. Lewicki ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Angiogenesis ◽  
Herbal Remedy ◽  
Inhibitory Effect ◽  
Inflammatory Drug ◽  
Anticancer Effects ◽  
Biologic Response ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Anticancer activity of many herbs was observed for hundreds of years. They act as modifiers of biologic response, and their effectiveness may be increased by combining multiple herbal extracts . PERVIVO, traditional digestive herbal remedy, contains some of them, and we previously described its antiangiogenic activity. Numerous studies documented anticancer effects of nonsteroidal anti-inflammatory drugs. We were the first to show that sulindac and its metabolites inhibit angiogenesis. In the present paper the combinedin vivoeffect of multicomponent herbal remedy PERVIVO and nonsteroidal anti-inflammatory drug sulindac on tumor growth, tumor angiogenesis, and tumor volume in Balb/c mice was studied. These effects were checked after grafting cells collected from syngeneic sarcoma L-1 tumors into mice skin. The strongest inhibitory effect was observed in experimental groups treated with PERVIVO and sulindac together. The results of our investigation showed that combined effect of examined drugs may be the best way to get the strongest antiangiogenic and antitumor effect.

Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats

1991 ◽  
Vol 12 (10) ◽  
pp. 1949-1952 ◽  
Author(s):  
Takuji Tanaka ◽  
Toshihiro Kojima ◽  
Naoki Yoshimi ◽  
Shigeyuki Sugie ◽  
Hideki Mori
Keyword(s):  
Inhibitory Effect ◽  
Inflammatory Drug ◽  
Naturally Occurring ◽  
Anti Inflammatory

scholarly journals Nonsteroidal Anti-Inflammatory Drug-Induced Severe Hyponatremia

Medicina ◽  
2012 ◽  
Vol 48 (12) ◽  
pp. 90 ◽  
Author(s):  
Mehmet Demir ◽  
Mehmet Horoz ◽  
Turgay Ulas ◽  
Mehmet Eren ◽  
Zafer Ercan
Keyword(s):  
Water Retention ◽  
Serum Sodium Level ◽  
Free Water ◽  
Inhibitory Effect ◽  
Severe Hyponatremia ◽  
Drug Induced ◽  
Water Excretion ◽  
Inflammatory Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Hyponatremia (serum sodium level, <135 mmol/L) occasionally may develop in the course of treatment with nonsteroidal anti-inflammatory drugs, which are usually used in daily clinical practice. Nonsteroidal anti-inflammatory drugs diminish the normal inhibitory effect of prostaglandins on the activity of antidiuretic hormone and can therefore reduce free water excretion, leading to water retention and induction or exacerbation of hyponatremia. In this report, we present a case of hyponatremia in a 78-year-old man who had received meloxicam, a nonsteroidal anti-inflammatory drug.

scholarly journals In silico and in vitro Study of the Inhibitory Effect of Antiinflammatory Drug Betamethasone on Two Lipases

2020 ◽  
Vol 19 (4) ◽  
pp. 387-392
Author(s):  
Nia Samira ◽  
Benarous Khedidja ◽  
Abdelalim Fatima Zahra ◽  
Chellali Khadidja Nour Elyakine ◽  
Yousfi Mohamed
Keyword(s):  
Molecular Docking ◽  
In Silico ◽  
Candida Rugosa ◽  
In Vitro Study ◽  
Antiinflammatory Drug ◽  
Inhibitory Effect ◽  
Vitro Study ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Background: For the first time, the anti-inflammatory drug betamethasone is investigated for its inhibitory activity against lipase. Objective: This work aims to demonstrate the in vitro and in silico inhibitory effect of the anti-inflammatory drug betamethasone on the enzymatic activity of two lipases. Methods: In vitro study using p-nitrophenyllaurate as lipase substrate is used to determine inhibition potency. Molecular Docking is performed using the Autodock Vina for drug molecule and two enzymes Candida rugosa lipase and human pancreatic lipase. Results: Betamethasone represents a moderate inhibition effect with a value of IC50 of 0.36±0.01 mg/ml. Molecular docking allowed us to understand inhibitory – enzyme interactions and to confirm in vitro obtained results. Conclusion: These experiments showed that betamethasone can be used in the treatment of diseases related to lipase activity.

scholarly journals An inhibitory effect of meloxicam, a novel nonsteroidal anti-inflammatory drug, on COX-2.

1996 ◽  
Vol 71 ◽  
pp. 304
Author(s):  
Keiko Ogino ◽  
Yoshiteru Harada ◽  
Michiko Kawamura ◽  
Ko Hatanaka ◽  
Saori Tsuda ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Inflammatory Drug ◽  
Cox 2 ◽  
Anti Inflammatory

Renal targeting of a non-steroidal anti-inflammatory drug: effects on renal prostaglandin synthesis in the rat

1998 ◽  
Vol 95 (5) ◽  
pp. 603-609 ◽  
Author(s):  
Marijke HAAS ◽  
Frits MOOLENAAR ◽  
Dirk K. F. MEIJER ◽  
Paul E. DE JONG ◽  
Dick DE ZEEUW
Keyword(s):  
Prostaglandin E2 ◽  
Rat Kidney ◽  
Drug Effects ◽  
Fold Increase ◽  
Inhibitory Effect ◽  
High Dose ◽  
Water Excretion ◽  
Inflammatory Drug ◽  
Baseline Conditions ◽  
Anti Inflammatory

1.Renal specific targeting of the non-steroidal anti-inflammatory drug naproxen was obtained by coupling to the low-molecular-mass protein lysozyme. A previous study showed that conjugation to lysozyme resulted in a 70-fold increase of naproxen accumulation in the kidney with a subsequent renal release of the active metabolite naproxen–lysine. 2.In the present study we questioned whether naproxen–lysozyme is active in the rat kidney, inhibiting the urinary excretion of prostaglandin E2 and renal sodium and water excretion in salt-restricted baseline conditions as well as during frusemide treatment. 3.A high dose of free naproxen (10 ;mg·day-1·kg-1) did not affect prostaglandin E2 excretion in baseline conditions (naproxen, 11±1 ;ng/8 ;h; vehicle, 13±4 ;ng/8 ;h), whereas sodium and water excretion were, respectively, 3.0 and 1.6 times lower in the naproxen group (P< 0.05). Naproxen completely prevented the frusemide-induced increase (3-fold) in prostaglandin E2 excretion (naproxen 6.6±1.1 ;ng/8 ;h, vehicle 40±12 ;ng/8 ;h, P< 0.005). Frusemide-stimulated natriuresis and diuresis were, respectively, 1.6 (P< 0.05) and 1.8 times (P< 0.005) lower in the naproxen group. 4.A dose of 2 ;mg·day-1·kg-1 lysozyme-conjugated naproxen did not affect prostaglandin E2 excretion in baseline conditions (conjugate, 18±2 ;ng/8 ;h; vehicle, 24±5 ;ng/8 ;h). The conjugate also had no effect on sodium and water excretion. However, the naproxen conjugate completely prevented the frusemide-induced increase (2-fold) in prostaglandin E2 excretion (conjugate, 16±3 ;ng/8 ;h; vehicle, 48±13 ;ng/8 ;h, P< 0.05). Surprisingly, frusemide-induced natriuresis and diuresis were not affected by the conjugate. 5.In conclusion, a renal specific delivery of the non-steroidal anti-inflammatory drug naproxen using lysozyme results in an inhibitory effect on renal prostaglandin E2 synthesis but does not affect the excretion of sodium and water, in contrast to free naproxen.

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