scholarly journals General pharmacological action of 4-(o-Benzylphenoxy)-N-methylamine hydrochloride (bifemelane hydrochloride, MCI-2016) - Influence on the central nervous system.

1986 ◽  
Vol 87 (2) ◽  
pp. 143-159 ◽  
Author(s):  
Akihiro TOBE ◽  
Mitsuo EGAWA ◽  
Noriko HASHIMOTO ◽  
Rie NAGAI ◽  
Kouko ISHIKAWA ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pharmacological Action ◽  
Methylamine Hydrochloride ◽  
The Central Nervous System ◽  
Bifemelane Hydrochloride

scholarly journals Anticonvulsant activity of 5-(furan-2-yl)-4R1-1,2,4-triazole-3-thione S-derivatives

2018 ◽  
pp. 56-60
Author(s):  
V. V. Parchenko
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Side Effects ◽  
Anticonvulsant Activity ◽  
Pharmacological Action ◽  
Biologically Active ◽  
Huge Number ◽  
Theoretical Computer ◽  
Relevant Today ◽  
The Central Nervous System

Among the huge number of drugs registered in Ukraine anticonvulsants occupy a special place. They are mainly used for the relief of different etiology seizures. Along with the principal pharmacological action of drugs in this group there were exhibited a number of unwanted side effects. Therefore the question of the searching for new biologically active molecules, remains relevant today and is necessary for the further practical introduction into medical practice. The purpose of our work was to study the anticonvulsant activity of 5- (furan-2-yl) -4R1-1,2,4-triazole-3-thione S-derivatives. The anticonvulsant activity study of the 5-(furan-2-yl)-2H-1,2,4-triazole-3-thione S-derivatives and 5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiones were conducted on the test of interaction with agents that stimulate the central nervous system. The theoretical computer predictions indicate the prospects in searching among the represented compounds classes. The criteria for assessing anticonvulsant activity were the changings in attack seizures latency and their duration. Reference drugs were Mydocalmum and Phenobarbital. Among the studied substances two compounds had the highest activity which is equivalent in strength to the activity of reference drugs. Two compounds among the studied substances have the highest activity which is equivalent in strength to Mydocalm activity/ Also 2-[5-(furan-2-yl)-4-fenil-4H-1,2,4-triazole-3-ylthio]-1-(4-chlorfeniletanon) must be noted, whose activity exceeds the activity of Phenobarbitalum and Midokalm in 1,23 and 1,27 times respectively on korazol model of seizures in rats. For some classes of 1,2,4-triaxole-3-thione 5-furanderivatives there were established structure–action patterns.

Effects of Glipizide on β-Endorphin Secretions in Response to Hyperglycaemia in Obese Cafeteria Rats

1989 ◽  
Vol 17 (6) ◽  
pp. 539-546 ◽  
Author(s):  
J. P. Belon ◽  
M. Orosco ◽  
J. C. Henry ◽  
C. Jacquot
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Glucose ◽  
Glucose Metabolism ◽  
Pharmacological Action ◽  
Neural Mechanisms ◽  
Considerable Evidence ◽  
Experimental Animals ◽  
The Central Nervous System

Regulation of blood glucose involves the integration of the central nervous system with both hormonal and neural mechanisms. Considerable evidence suggests that β-endorphin is involved in the regulation of feeding in experimental animals and man. Previous studies have shown that β-endorphin plays an important role during hypergiycaemia. Glipizide has been shown to increase glucose metabolism by both pancreatic and extrapancreatic actions. This study indicates that glipizide may exert its pharmacological action in obese cafeteria rats through a modification of β-endorphin secretions via central and peripheral mechanisms.

Effects of Hyperoxia on Lung Utrastructure

1970 ◽  
Vol 28 ◽  
pp. 26-27
Author(s):  
Gladys Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Light Microscopy ◽  
Oxygen Effects ◽  
Age Dependent ◽  
The Central Nervous System ◽  
The Subject ◽  
Space Age ◽  
Alveolar Septa ◽  
Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

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