scholarly journals Antiedema effects of basic nonsteroidal anti-inflammatory drugs that are not inhibitors of prostaglandin biosynthesis.

1985 ◽  
Vol 85 (5) ◽  
pp. 343-346
Author(s):  
Shohei HIGUCH ◽  
Susumu OTOMO ◽  
Hironaka AIHARA
Keyword(s):  
Prostaglandin Biosynthesis ◽  
Inhibitors Of Prostaglandin Biosynthesis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Effects of Anti-inflammatory Drugs on Prostaglandin Biosynthesis

1972 ◽  
Vol 238 (82) ◽  
pp. 104-106 ◽  
Author(s):  
R. FLOWER ◽  
R. GRYGLEWSKI ◽  
K. HERBACZŃSKA-CEDRO ◽  
J. R. VANE
Keyword(s):  
Prostaglandin Biosynthesis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Carbachol interactions with nonsteroidal anti-inflammatory drugs

2002 ◽  
Vol 80 (12) ◽  
pp. 1173-1179 ◽  
Author(s):  
H F Miranda ◽  
F Sierralta ◽  
G Pinardi
Keyword(s):  
Test Dose ◽  
Antinociceptive Activity ◽  
Simultaneous Administration ◽  
Response Curves ◽  
Additional Mechanism ◽  
Writhing Test ◽  
Prostaglandin Biosynthesis ◽  
Isobolographic Analysis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The inhibition of cyclooxygenase enzymes by nonsteroidal anti-inflammatory drugs (NSAIDs) does not completely explain the antinociceptive efficacy of these agents. It is known that cholinergic agonists are antinociceptive, and this study evaluates the interactions between carbachol and some NSAIDs. Antinociceptive activity was evaluated in mice by the acetic acid writhing test. Dose–response curves were constructed for NSAIDs and carbachol, administered either intraperitoneally (i.p.) or intrathecally (i.t.). The interactions of carbachol with NSAIDs were evaluated by isobolographic analysis after the simultaneous administration of fixed proportions of carbachol with each NSAID. All of the drugs were more potent after spinal than after systemic administration. The combinations of NSAIDs and carbachol administered i.p. were supra-additive; however, the i.t. combinations were only additive. Isobolographic analysis of the coadministration of NSAIDs and carbachol and the fact that atropine antagonized the synergistic effect suggest that carbachol may strongly modulate the antinociceptive activity of NSAIDs; thus, central cholinergic modulation would be an additional mechanism for the antinociceptive action of NSAIDs, unrelated to prostaglandin biosynthesis inhibition.Key words: antinociception, nonsteroidal anti-inflammatory drugs, cholinergic, carbachol, writhing test.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source
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