scholarly journals Effect of nizofenone on pyramidal response, electrocorticogram and regional cerebral blood flow following recirculation after complete global brain ischemia in cats.

1984 ◽  
Vol 84 (6) ◽  
pp. 519-528
Author(s):  
Shigetoshi SHUTO ◽  
Teruhito USA ◽  
Tatsumi TSUMAGARI ◽  
Akira NAKAJIMA
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Ischemia ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Global Brain Ischemia ◽  
Global Brain

Mismatch Recovery of Regional Cerebral Blood Flow and Brain Temperature During Reperfusion After Prolonged Brain Ischemia in Gerbils

2007 ◽  
Vol 62 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Goro Tajima ◽  
Tadahiko Shiozaki ◽  
Akitoshi Seiyama ◽  
Tomoyoshi Mohri ◽  
Kentaro Kajino ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Ischemia ◽  
Regional Cerebral Blood Flow ◽  
Brain Temperature ◽  
Regional Cerebral Blood

scholarly journals Uncoupled Cerebral Blood Flow and Metabolism after Severe Global Ischemia in Rats

1992 ◽  
Vol 12 (5) ◽  
pp. 802-808 ◽  
Author(s):  
Narendra C. Singh ◽  
Patrick M. Kochanek ◽  
Joanne K. Schiding ◽  
John A. Melick ◽  
Edwin M. Nemoto
Keyword(s):  
Blood Flow ◽  
Cardiac Arrest ◽  
Cerebral Blood Flow ◽  
Brain Ischemia ◽  
Global Ischemia ◽  
Global Brain Ischemia ◽  
Sagittal Sinus ◽  
Postischemic Period ◽  
Baseline Values ◽  
Global Brain

In a rat model of complete global brain ischemia (neck tourniquet) lasting either 3 min or 20 min, we monitored global CBF (sagittal sinus H2 clearance) and CMRO2 for 6 h to test the hypothesis that delayed postischemic hyperemia and uncoupling of CBF and CMRO2 occur depending on the severity of the insult. Early postischemic hyperemia occurred in both the 3-min and 20-min groups ( p < 0.05 vs. baseline values) and resolved by 15 min. Hypoperfusion occurred in the 3-min group between 15 and 60 min postischemia (≈23% reduction), and in the 20-min group from 15 to 120 min postischemia (≈50% reduction) ( p < 0.05), and then resolved. CMRO2 was not significantly different from baseline at any time after ischemia in the 3-min group. After 20 min of ischemia, however, CMRO2 was decreased (≈60%) throughout the postischemic period ( p < 0.05). At 5 min after ischemia, CBF/CMRO2 was increased in both groups but returned to baseline from 60 to 120 min postischemia. In the 3-min group, CBF/CMRO2 remained at baseline throughout the rest of the experiment. However, in the 20-min group, CBF/CMRO2 once again increased (≈100%), reaching a significant level at 180 min and remaining so for the rest of the 6-h period ( p < 0.05). These data demonstrate biphasic uncoupling of CBF and CMRO2 after severe (20 min) global ischemia in rats. This relatively early reemergence of CBF/CMRO2 uncoupling after 180 min of reperfusion is similar to that observed after prolonged cardiac arrest and resuscitation in humans.

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