scholarly journals Regulation mechanism of autonomic function on N. 1. cr. int. Chapter 2. On respiratory reflex

1963 ◽  
Vol 59 (5) ◽  
pp. 287-306 ◽  
Author(s):  
Kikuji TOKITA ◽  
Miyako OHMOTO ◽  
Shigeru YASHIKI ◽  
Yoshikata HIROSHIBA ◽  
Yasuke YAGI ◽  
...  
Keyword(s):  
Autonomic Function ◽  
Regulation Mechanism ◽  
Respiratory Reflex

554-P: Dapagliflozin and Measures of Cardiovascular Autonomic Function in Patients with Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 554-P
Author(s):  
LYNN ANG ◽  
KELLEY M. KIDWELL ◽  
JACOB REISS ◽  
BRENDAN R. DILLON ◽  
KARA R. MIZOKAMI-STOUT ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Function ◽  
Cardiovascular Autonomic Function

Role of 4-O Galloylchlorogenic Acid in Lung Cancer- An Insilico Approach

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Jaynthy C. ◽  
N. Premjanu ◽  
Abhinav Srivastava
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
In Silico ◽  
Computational Study ◽  
Regulation Mechanism ◽  
Down Regulation ◽  
Fruit Extract ◽  
In Vitro Techniques ◽  
Discovery Studio

Cancer is a major disease with millions of patients diagnosed each year with high mortality around the world. Various studies are still going on to study the further mechanisms and pathways of the cancer cell proliferation. Fucosylation is one of the most important oligosaccharide modifications involved in cancer and inflammation. In cancer development increased core fucosylation by FUT8 play an important role in cell proliferation. Down regulation of FUT8 expression may help cure lung cancer. Therefore the computational study based on the down regulation mechanism of FUT8 was mechanised. Sapota fruit extract, containing 4-Ogalloylchlorogenic acid was used as the inhibitor against FUT-8 as target and docking was performed using in-silico tool, Accelrys Discovery Studio. There were several conformations of the docked result, and conformation 1 showed 80% dock score between the ligand and the target. Further the amino acids of the inhibitor involved in docking were studied using another tool, Ligplot. Thus, in-silico analysis based on drug designing parameters shows that the fruit extract can be studied further using in-vitro techniques to know its pharmacokinetics.

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