Pharmacological characteristics and clinical study results of Pemigatinib (Pemazyre<sup>®</sup> Tablets), a selective fibroblast growth factor receptor (FGFR) inhibitor

Koki Kabu; Satoko Takei; Midori Kondo; Kazuya Kitazawa; Takashi Harada

doi:10.1254/fpj.21087

Pharmacological characteristics and clinical study results of Pemigatinib (Pemazyre® Tablets), a selective fibroblast growth factor receptor (FGFR) inhibitor

Folia Pharmacologica Japonica ◽

10.1254/fpj.21087 ◽

2021 ◽

Vol 156 (6) ◽

pp. 392-402

Author(s):

Koki Kabu ◽

Satoko Takei ◽

Midori Kondo ◽

Kazuya Kitazawa ◽

Takashi Harada

Keyword(s):

Clinical Study ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Fibroblast Growth ◽

Study Results

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Fibroblast Growth Factor Receptor 4

10.32388/xtxa2z ◽

2020 ◽

Author(s):

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Fibroblast Growth

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Faculty Opinions recommendation of Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1014779.194603 ◽

2003 ◽

Author(s):

Sjur Olsnes

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Fibroblast Growth ◽

Receptor Signalling

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Faculty Opinions recommendation of The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022433.254707 ◽

2004 ◽

Author(s):

Kermit Carraway

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Kinase Activity ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Receptor Trafficking ◽

Activation Loop ◽

Fibroblast Growth

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Faculty Opinions recommendation of Effect of ganglioside and tetraspanins in microdomains on interaction of integrins with fibroblast growth factor receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1026857.327437 ◽

2005 ◽

Author(s):

Sjur Olsnes

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Fibroblast Growth

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Faculty Opinions recommendation of Spatiotemporal control of fibroblast growth factor receptor signals by blue light.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718475804.793499467 ◽

2014 ◽

Author(s):

Simon Cook ◽

Hannah Johnson

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Blue Light ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Fibroblast Growth ◽

Spatiotemporal Control

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Disruption of Fibroblast Growth Factor Receptor (FGFR) Signaling as an Approach to Prostate Cancer Therapy

10.21236/ada455329 ◽

2006 ◽

Author(s):

Mustafa Ozen

Keyword(s):

Prostate Cancer ◽

Growth Factor ◽

Cancer Therapy ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Fibroblast Growth ◽

Prostate Cancer Therapy ◽

Fgfr Signaling

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Fibroblast Growth Factor Receptor Inhibitors

Current Pharmaceutical Design ◽

10.2174/13816128130409 ◽

2012 ◽

Vol 19 (4) ◽

pp. 687-701

Author(s):

Suneel Kumar B.V.S ◽

Lakshmi Narasu ◽

Rambabu Gundla ◽

Raveendra Dayam ◽

Sarma J.A.R.P

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Fibroblast Growth

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Molecular Modeling, de novo Design and Synthesis of a Novel, Extracellular Binding Fibroblast Growth Factor Receptor 2 Inhibitor Alofanib (RPT835)

Medicinal Chemistry ◽

10.2174/1573406412666160106154726 ◽

2016 ◽

Vol 12 (4) ◽

pp. 303-317 ◽

Cited By ~ 6

Author(s):

Ilya Tsimafeyeu ◽

Frits Daeyaert ◽

Jean-Baptiste Joos ◽

Koen V. Aken ◽

John Ludes-Meyers ◽

...

Keyword(s):

Molecular Modeling ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

De Novo ◽

Growth Factor Receptor ◽

De Novo Design ◽

Fibroblast Growth ◽

Design And Synthesis

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Enhanced Expression of Fibroblast Growth Factor Receptor 3 in Human Skin Cancer Cells

The Open Circulation & Vascular Journal ◽

10.2174/1877382600902010030 ◽

2009 ◽

Vol 2 (1) ◽

pp. 30-36 ◽

Cited By ~ 2

Author(s):

Motoki Terada ◽

Chikara Ohnishi ◽

Nobuhiro Ueno ◽

Akio Shimizu ◽

Michiyuki Kanai ◽

...

Keyword(s):

Growth Factor ◽

Skin Cancer ◽

Cancer Cells ◽

Fibroblast Growth Factor ◽

Human Skin ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Fibroblast Growth ◽

Enhanced Expression

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Primary and Secondary Dimer Interfaces of the Fibroblast Growth Factor Receptor 3 Transmembrane Domain: Characterization via Multiscale Molecular Dynamics Simulations

Biochemistry ◽

10.1021/bi401576k ◽

2014 ◽

Vol 53 (2) ◽

pp. 323-332 ◽

Cited By ~ 18

Author(s):

Tyler Reddy ◽

Santiago Manrique ◽

Amanda Buyan ◽

Benjamin A. Hall ◽

Alan Chetwynd ◽

...

Keyword(s):

Molecular Dynamics ◽

Growth Factor ◽

Molecular Dynamics Simulations ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Transmembrane Domain ◽

Growth Factor Receptor ◽

Fibroblast Growth ◽

Dynamics Simulations

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