Doxorubicin directly induced fibrotic change of cardiac fibroblasts

2021 ◽  
Vol 156 (3) ◽  
pp. 146-151
Author(s):  
Masanari Umemura ◽  
Masatoshi Narikawa ◽  
Ryo Tanaka ◽  
Hiroko Nemoto ◽  
Rina Nakakaji ◽  
...  
Keyword(s):  
Cardiac Fibroblasts ◽  
Fibrotic Change

DOXORUBICIN DIRECTLY INDUCED FIBROTIC CHANGE OF CARDIAC FIBROBLASTS AND MATRIX METALLOPROTEINASE-1

2019 ◽  
Vol 73 (9) ◽  
pp. 822
Author(s):  
Masatoshi Narikawa ◽  
Masanari Umemura ◽  
Ryo Tanaka ◽  
Tomoaki Ishigami ◽  
Koichi Tamura ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Cardiac Fibroblasts ◽  
Fibrotic Change ◽  
Matrix Metalloproteinase 1

Protective role of peroxiredoxin-4 in heart failure

2020 ◽  
Vol 134 (1) ◽  
pp. 71-72
Author(s):  
Naseer Ahmed ◽  
Masooma Naseem ◽  
Javeria Farooq
Keyword(s):  
Heart Failure ◽  
Cardiac Fibroblasts ◽  
Protective Role ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Galectin 3 ◽  
Consequent Increase ◽  
And Oxidative Stress

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.

Grafting of Connexin43 (Cx43) Overexpressing Cardiac Fibroblasts Protects from Postinfarct Arrhythmia

2020 ◽  
Author(s):  
M. Schiffer ◽  
E. Carls ◽  
G. D. Dürr ◽  
H. Treede ◽  
J. M. Delafuente ◽  
...  
Keyword(s):  
Cardiac Fibroblasts

Luteolin Antagonizes Angiotensin II-Dependent Proliferation and Collagen Synthesis of Cultured rat Cardiac Fibroblasts

2015 ◽  
Vol 16 (5) ◽  
pp. 430-439 ◽  
Author(s):  
Tingting Wang ◽  
Defeng Pan ◽  
Yingying Zhang ◽  
Dongye Li ◽  
Yanbin Zhang ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Collagen Synthesis ◽  
Cardiac Fibroblasts

Natriuretic Peptides Inhibit DNA Synthesis in Cardiac Fibroblasts

Hypertension ◽  
1995 ◽  
Vol 25 (2) ◽  
pp. 227-234 ◽  
Author(s):  
Li Cao ◽  
David G. Gardner
Keyword(s):  
Dna Synthesis ◽  
Natriuretic Peptides ◽  
Cardiac Fibroblasts

Prostacyclin Release by Rat Cardiac Fibroblasts

Hypertension ◽  
1997 ◽  
Vol 30 (5) ◽  
pp. 1047-1053 ◽  
Author(s):  
Hisahiro Yu ◽  
Ann Marie Gallagher ◽  
Phillip M. Garfin ◽  
Morton P. Printz
Keyword(s):  
Cardiac Fibroblasts
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