scholarly journals Alcohol dependence and opioid receptor —Pharmacological profile of nalmefene—

2020 ◽  
Vol 155 (3) ◽  
pp. 145-148
Author(s):  
Yuta Ohgi
Keyword(s):  
Alcohol Dependence ◽  
Opioid Receptor ◽  
Pharmacological Profile

scholarly journals Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence

2021 ◽  
pp. 026988112199199 ◽  
Author(s):  
Miriam Sebold ◽  
Maria Garbusow ◽  
Deniz Cerci ◽  
Ke Chen ◽  
Christian Sommer ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Opioid Receptor ◽  
Mechanistic Model ◽  
Critical Role ◽  
Opioid System ◽  
Operant Behaviour ◽  
Oprm1 Gene ◽  
Potential Biomarker ◽  
A118g Polymorphism

Background: Pavlovian-to-instrumental transfer (PIT) quantifies the extent to which a stimulus that has been associated with reward or punishment alters operant behaviour. In alcohol dependence (AD), the PIT effect serves as a paradigmatic model of cue-induced relapse. Preclinical studies have suggested a critical role of the opioid system in modulating Pavlovian–instrumental interactions. The A118G polymorphism of the OPRM1 gene affects opioid receptor availability and function. Furthermore, this polymorphism interacts with cue-induced approach behaviour and is a potential biomarker for pharmacological treatment response in AD. In this study, we tested whether the OPRM1 polymorphism is associated with the PIT effect and relapse in AD. Methods: Using a PIT task, we examined three independent samples: young healthy subjects ( N = 161), detoxified alcohol-dependent patients ( N = 186) and age-matched healthy controls ( N = 105). We used data from a larger study designed to assess the role of learning mechanisms in the development and maintenance of AD. Subjects were genotyped for the A118G (rs1799971) polymorphism of the OPRM1 gene. Relapse was assessed after three months. Results: In all three samples, participants with the minor OPRM1 G-Allele (G+ carriers) showed increased expression of the PIT effect in the absence of learning differences. Relapse was not associated with the OPRM1 polymorphism. Instead, G+ carriers displaying increased PIT effects were particularly prone to relapse. Conclusion: These results support a role for the opioid system in incentive salience motivation. Furthermore, they inform a mechanistic model of aberrant salience processing and are in line with the pharmacological potential of opioid receptor targets in the treatment of AD.

Pharmacological Profile of Naldemedine, a Peripheral Acting μ-Opioid Receptor Antagonist: Comparison With Naloxone and Naloxegol

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S96-S97
Author(s):  
Toshiyuki Kanemasa ◽  
Katsumi Koike ◽  
Kenji Takase ◽  
Tohko Arai ◽  
Atsushi Nakamura ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Opioid Receptor ◽  
Pharmacological Profile ◽  
Opioid Receptor Antagonist ◽  
Μ Opioid Receptor

scholarly journals An Evaluation of μ-Opioid Receptor (OPRM1) as a Predictor of Naltrexone Response in the Treatment of Alcohol Dependence

2008 ◽  
Vol 65 (2) ◽  
pp. 135 ◽  
Author(s):  
Raymond F. Anton ◽  
Gabor Oroszi ◽  
Stephanie O’Malley ◽  
David Couper ◽  
Robert Swift ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Opioid Receptor ◽  
Μ Opioid Receptor

scholarly journals Exploring the Backbone of Enkephalins To Adjust Their Pharmacological Profile for the δ-Opioid Receptor

2010 ◽  
Vol 1 (11) ◽  
pp. 757-769 ◽  
Author(s):  
Arnaud Proteau-Gagné ◽  
Véronique Bournival ◽  
Kristina Rochon ◽  
Yves L. Dory ◽  
Louis Gendron
Keyword(s):  
Opioid Receptor ◽  
Pharmacological Profile ◽  
Δ Opioid Receptor

Association of Functional Opioid Receptor Genotypes With Alcohol Dependence in Koreans

2004 ◽  
Vol 28 (7) ◽  
pp. 986-990 ◽  
Author(s):  
Sung-Gon Kim ◽  
Cheol-Min Kim ◽  
Dong-Ho Kang ◽  
Yun-Jin Kim ◽  
Won-Tan Byun ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Opioid Receptor

scholarly journals Association between two µ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence

2006 ◽  
Vol 15 (6) ◽  
pp. 807-819 ◽  
Author(s):  
Huiping Zhang ◽  
Xingguang Luo ◽  
Henry R. Kranzler ◽  
Jaakko Lappalainen ◽  
Bao-Zhu Yang ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Opioid Receptor ◽  
Receptor Gene ◽  
Haplotype Blocks
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