scholarly journals A new transgenic mouse model revealed a role of astrocytic calcium in vivo

2016 ◽  
Vol 148 (2) ◽  
pp. 69-74
Author(s):  
Mika Tanaka
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model

scholarly journals Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model

Biochimie ◽  
2021 ◽  
Author(s):  
Mélanie Dacheux ◽  
Soraya Chaouch ◽  
Alonso Joy ◽  
Amandine Labat ◽  
Christine Payré ◽  
...  
Keyword(s):  
Mouse Model ◽  
Phospholipase A2 ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Human Group ◽  
Secreted Phospholipase A2

scholarly journals Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia

2016 ◽  
Vol 8 (5) ◽  
pp. 517-528 ◽  
Author(s):  
Andrew E. Armitage ◽  
Pei Jin Lim ◽  
Joe N. Frost ◽  
Sant-Rayn Pasricha ◽  
Elizabeth J. Soilleux ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Brucella Abortus ◽  
Serum Iron ◽  
Vibrio Vulnificus ◽  
Iron Status ◽  
Transgenic Mouse Model ◽  
Innate Immune ◽  
Serum Hepcidin

Withdrawal of iron from serum (hypoferraemia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation. Mice lacking Hamp1 from birth rapidly accumulate iron and are susceptible to infection by blood-dwelling siderophilic bacteria such as Vibrio vulnificus. In order to study the innate immune role of hepcidin against a background of normal iron status, we developed a transgenic mouse model of tamoxifen-sensitive conditional Hamp1 deletion (termed iHamp1-KO mice). These mice attain adulthood with an iron status indistinguishable from littermate controls. Hamp1 disruption and the consequent decline of serum hepcidin concentrations occurred within hours of a single tamoxifen dose. We found that the TLR ligands LPS and Pam3CSK4 and heat-killed Brucella abortus caused an equivalent induction of inflammation in control and iHamp1-KO mice. Pam3CSK4 and B. abortus only caused a drop in serum iron in control mice, while hypoferraemia due to LPS was evident but substantially blunted in iHamp1-KO mice. Our results characterise a powerful new model of rapidly inducible hepcidin disruption, and demonstrate the critical contribution of hepcidin to the hypoferraemia of inflammation.

Transgenic mouse model for evaluation of the role of cyclin-dependent kinase 8 in vascular disease

2021 ◽  
Vol 331 ◽  
pp. e62
Author(s):  
E. Varlamova ◽  
A. Bruter ◽  
V. Mogila ◽  
I. Roninson ◽  
A. Deykin
Keyword(s):  
Mouse Model ◽  
Vascular Disease ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Cyclin Dependent Kinase

scholarly journals Multimodal In Vivo Imaging of Tumorigenesis and Response to Chemotherapy in a Transgenic Mouse Model of Mammary Cancer

2015 ◽  
Vol 18 (4) ◽  
pp. 617-626 ◽  
Author(s):  
Jean-Louis Alberini ◽  
Raphaël Boisgard ◽  
Stéphanie Guillermet ◽  
Karine Siquier ◽  
Benoît Jego ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
In Vivo Imaging ◽  
Mammary Cancer ◽  
Transgenic Mouse Model ◽  
Response To Chemotherapy
Sign in / Sign up

Export Citation Format

Share Document