scholarly journals Modeling and simulation of pharmacokinetic drug-drug interaction caused by induction of metabolic enzymes

2016 ◽  
Vol 147 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Fumiyoshi Yamashita
Keyword(s):  
Drug Interaction ◽  
Modeling And Simulation ◽  
Metabolic Enzymes ◽  
Drug Drug Interaction ◽  
Pharmacokinetic Drug

Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China

2020 ◽  
Vol 21 ◽  
Author(s):  
Xuan Yu ◽  
Zixuan Chu ◽  
Jian Li ◽  
Rongrong He ◽  
Yaya Wang ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Drug Interactions ◽  
Penicillin G ◽  
Literature Mining ◽  
Human Pharmacokinetics ◽  
P450 Enzyme ◽  
Drug Drug Interaction ◽  
Pharmacokinetic Drug ◽  
Sepsis Care

Background: Many antibiotics have a high potential for having an interaction with drugs, as perpetrator and/or victim, in critically ill patients, and particularly in sepsis patients. Methods: The aim of this review is to summarize the pharmacokinetic drug-drug interaction (DDI) of 45 antibiotics commonly used in sepsis care in China. Literature mining was conducted to obtain human pharmacokinetics/dispositions of the antibiotics, their interactions with drug metabolizing enzymes or transporters, and their associated clinical drug interactions. Potential DDI is indicated by a DDI index > 0.1 for inhibition or a treated-cell/untreated-cell ratio of enzyme activity being > 2 for induction. Results: The literature-mined information on human pharmacokinetics of the identified antibiotics and their potential drug interactions is summarized. Conclusion: Antibiotic-perpetrated drug interactions, involving P450 enzyme inhibition, have been reported for four lipophilic antibacterials (ciprofloxacin, erythromycin, trimethoprim, and trimethoprim-sulfamethoxazole) and three lipophilic antifungals (fluconazole, itraconazole, and voriconazole). In addition, seven hydrophilic antibacterials (ceftriaxone, cefamandole, piperacillin, penicillin G, amikacin, metronidazole, and linezolid) inhibit drug transporters in vitro. Despite no reported clinical PK drug interactions with the transporters, caution is advised in the use of these antibacterials. Eight hydrophilic antibacterials (all β-lactams; meropenem, cefotaxime, cefazolin, piperacillin, ticarcillin, penicillin G, ampicillin, and flucloxacillin), are potential victims of drug interactions due to transporter inhibition. Rifampin is reported to perpetrate drug interactions by inducing CYP3A or inhibiting OATP1B; it is also reported to be a victim of drug interactions, due to the dual inhibition of CYP3A4 and OATP1B by indinavir. In addition, three antifungals (caspofungin, itraconazole, and voriconazole) are reported to be victims of drug interactions because of P450 enzyme induction. Reports for other antibiotics acting as victims in drug interactions are scarce.

Pharmacokinetic drug–drug interaction assessment of peptibody trebananib in combination with chemotherapies

2015 ◽  
Vol 76 (2) ◽  
pp. 243-250 ◽  
Author(s):  
Benjamin Wu ◽  
Rebeca Melara ◽  
Erik Rasmussen ◽  
Lei Zhou ◽  
Teresa Wong ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Drug Drug Interaction ◽  
Pharmacokinetic Drug

A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers

2018 ◽  
Vol 74 (12) ◽  
pp. 1605-1613 ◽  
Author(s):  
Soyoung Lee ◽  
Yun Kim ◽  
Janice Ji Sung Lee ◽  
Guangjin Im ◽  
Joo-Youn Cho ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Healthy Volunteers ◽  
Interaction Study ◽  
Drug Interaction Study ◽  
Drug Drug Interaction ◽  
Pharmacokinetic Drug

Clinical Data Combined With Modeling and Simulation Indicate Unchanged Drug‐Drug Interaction Magnitudes in the Elderly

2020 ◽  
Author(s):  
Felix Stader ◽  
Perrine Courlet ◽  
Hannah Kinvig ◽  
Melissa A. Penny ◽  
Laurent A. Decosterd ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Modeling And Simulation ◽  
Clinical Data ◽  
The Elderly ◽  
Unchanged Drug ◽  
Drug Drug Interaction

scholarly journals Evaluation of the pharmacokinetic drug-drug interaction potential of iohexol, a renal filtration marker

2020 ◽  
Vol 86 (4) ◽  
pp. 535-545
Author(s):  
Anand Joshi ◽  
Jianxia Guo ◽  
Julianne L. Holleran ◽  
Brian Kiesel ◽  
Sarah Taylor ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Drug Drug Interaction ◽  
Pharmacokinetic Drug
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