scholarly journals The engineered thymidylate kinase (TMPK)/azidothymidine (AZT)-axis offers efficient bystander cell killing effect for suicide gene therapy for cancer

2016 ◽  
Vol 147 (6) ◽  
pp. 326-329 ◽  
Author(s):  
Takeya Sato ◽  
Teruyuki Yanagisawa
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Cell Killing ◽  
Suicide Gene Therapy ◽  
Bystander Cell ◽  
Killing Effect ◽  
Thymidylate Kinase ◽  
Cell Killing Effect

scholarly journals The Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis Offers Efficient Bystander Cell Killing for Suicide Gene Therapy of Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e78711 ◽  
Author(s):  
Takeya Sato ◽  
Anton Neschadim ◽  
Arnon Lavie ◽  
Teruyuki Yanagisawa ◽  
Jeffrey A. Medin
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Cell Killing ◽  
Suicide Gene Therapy ◽  
Bystander Cell ◽  
Thymidylate Kinase

scholarly journals 140. Enhanced Cell Killing Effect of E1 Modified Adenoviruses Expressing HSV-TK Suicide Gene

2006 ◽  
Vol 13 ◽  
pp. S56
Author(s):  
Oh-Joon Kwon ◽  
Dong Hyun Ko ◽  
Jing Hwa Huang ◽  
Il-Kyu Choi ◽  
Sung-Mi Jung ◽  
...  
Keyword(s):  
Suicide Gene ◽  
Cell Killing ◽  
Killing Effect ◽  
Cell Killing Effect

Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment

2020 ◽  
Vol 3 (8) ◽  
pp. 2000007
Author(s):  
Lucia Salvioni ◽  
Stefania Zuppone ◽  
Francesco Andreata ◽  
Matteo Monieri ◽  
Serena Mazzucchelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Cancer Treatment ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Suicide Gene ◽  
Breast Cancer Treatment ◽  
Suicide Gene Therapy

scholarly journals Development of iRGD-Modified Peptide Carriers for Suicide Gene Therapy of Uterine Leiomyoma

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 202
Author(s):  
Anna Egorova ◽  
Sofia Shtykalova ◽  
Alexander Selutin ◽  
Natalia Shved ◽  
Marianna Maretina ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Uterine Leiomyoma ◽  
Transfection Efficiency ◽  
Chemical Properties ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Benign Tumors ◽  
Αvβ3 Integrin ◽  
Peptide Carrier ◽  
Plasmid Delivery

Uterine leiomyoma (UL) is one of the most common benign tumors in women that often leads to many reproductive complications. Suicide genetherapy was suggested as a promising approach for UL treatment. In the present study, we describe iRGD ligand-conjugated cysteine-rich peptide carrier RGD1-R6 for targeted DNA delivery to αvβ3 integrin-expressing primary UL cells. The physico-chemical properties, cytotoxicity, transfection efficiency and specificity of DNA/RGD1-R6 polyplexes were investigated. TheHSV-1thymidine kinase encoding plasmid delivery to PANC-1pancreatic carcinoma cells and primary UL cells resulted in significant suicide gene therapy effects. Subsequent ganciclovir treatment decreased cells proliferative activity, induced of apoptosis and promoted cells death.The obtained results allow us to concludethatthe developed RGD1-R6 carrier can be considered a promising candidate for suicide gene therapy of uterine leiomyoma.

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