scholarly journals Langendorff perfusion heart model

2012 ◽  
Vol 140 (4) ◽  
pp. 166-169
Author(s):  
Yuji Nakamura ◽  
Kentaro Ando ◽  
Atsushi Sugiyama
Keyword(s):  
Heart Model ◽  
Langendorff Perfusion

Analysis of the Pulse-Modulated Microwave Propagation into 3D Anisotropic Heart Model by SIE Method

PIERS Online ◽  
2009 ◽  
Vol 5 (4) ◽  
pp. 389-392
Author(s):  
Liudmila Nickelson ◽  
Steponas Asmontas ◽  
Romanas Martavicius ◽  
Vadim Engelson
Keyword(s):  
Heart Model ◽  
Microwave Propagation

Dobutamine responsiveness, PET mismatch, and lack of necrosis in low-flow ischemia: is this hibernation in the isolated rat heart?

2003 ◽  
Vol 285 (1) ◽  
pp. H316-H324 ◽  
Author(s):  
Richard Southworth ◽  
Pamela B. Garlick
Keyword(s):  
Rat Heart ◽  
Recovery Of Function ◽  
Electron Microscopic Examination ◽  
Left Ventricular ◽  
Isolated Rat Heart ◽  
Low Flow ◽  
Hibernating Myocardium ◽  
Heart Model ◽  
Electron Microscopic ◽  
Isolated Rat

The clinical hallmarks of hibernating myocardium include hypocontractility while retaining an inotropic reserve (using dobutamine echocardiography), having normal or increased [18F]fluoro-2-deoxyglucose-6-phosphate (18FDG6P) accumulation associated with decreased coronary flow [flow-metabolism mismatch by positron emission tomography (PET)], and recovering completely postrevascularization. In this study, we investigated an isolated rat heart model of hibernation using experimental equivalents of these clinical techniques. Rat hearts ( n = 5 hearts/group) were perfused with Krebs-Henseleit buffer for 40 min at 100% flow and 3 h at 10% flow and reperfused at 100% flow for 30 min (paced at 300 beats/min throughout). Left ventricular developed pressure fell to 30 ± 8% during 10% flow and recovered to 90 ± 7% after reperfusion. In an additional group, this recovery of function was found to be preserved over 2 h of reperfusion. Electron microscopic examination of hearts fixed at the end of the hibernation period demonstrated a lack of ischemic injury and an accumulation of glycogen granules, a phenomenon observed clinically. In a further group, hearts were challenged with dobutamine during the low-flow period. Hearts demonstrated an inotropic reserve at the expense of increased lactate leakage, with no appreciable creatine kinase release. PET studies used the same basic protocol in both dual- and globally perfused hearts (with 250MBq18FDG in Krebs buffer ± 0.4 mmol/l oleate). PET data showed flow-metabolism “mismatch;” whether regional or global,18FDG6P accumulation in ischemic tissue was the same as (glucose only) or significantly higher than (glucose + oleate) control tissue (0.023 ± 0.002 vs. 0.011 ± 0.002 normalized counts · s-1· g-1· min-1, P < 0.05) despite receiving 10% of the flow. This isolated rat heart model of acute hibernation exhibits many of the same characteristics demonstrated clinically in hibernating myocardium.

Tris-hydroxymethyl aminomethane and sodium bicarbonate to buffer metabolic acidosis in an isolated heart model.

1997 ◽  
Vol 155 (3) ◽  
pp. 957-963 ◽  
Author(s):  
D Sirieix ◽  
S Delayance ◽  
M Paris ◽  
S Massonnet-Castel ◽  
A Carpentier ◽  
...  
Keyword(s):  
Metabolic Acidosis ◽  
Sodium Bicarbonate ◽  
Isolated Heart ◽  
Heart Model

Thermal analysis of nanowarming in a human heart and a rat heart model

Cryobiology ◽  
2020 ◽  
Vol 97 ◽  
pp. 264
Author(s):  
Purva Joshi ◽  
John Bischof ◽  
Yoed Rabin
Keyword(s):  
Thermal Analysis ◽  
Rat Heart ◽  
Human Heart ◽  
Heart Model

High-Order Cardiomyopathy Human Heart Model and Mesh Generation

2021 ◽  
Author(s):  
Fariba Mohammadi ◽  
Suzanne M Shontz ◽  
Cristian A Linte
Keyword(s):  
Mesh Generation ◽  
Human Heart ◽  
High Order ◽  
Heart Model
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