scholarly journals Application of Lab-on-a-chip technology to drug discovery

2008 ◽  
Vol 131 (1) ◽  
pp. 28-31
Author(s):  
Kiyoshi Takayama
Keyword(s):  
Drug Discovery ◽  
Lab On A Chip ◽  
Chip Technology

scholarly journals Revisiting lab-on-a-chip technology for drug discovery

2012 ◽  
Vol 11 (8) ◽  
pp. 620-632 ◽  
Author(s):  
Pavel Neužil ◽  
Stefan Giselbrecht ◽  
Kerstin Länge ◽  
Tony Jun Huang ◽  
Andreas Manz
Keyword(s):  
Drug Discovery ◽  
Lab On A Chip ◽  
Chip Technology

scholarly journals Testing Lab-on-a-Chip Technology for Culturing Human Melanoma Cells under Simulated Microgravity

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 402
Author(s):  
Dawid Przystupski ◽  
Agata Górska ◽  
Olga Michel ◽  
Agnieszka Podwin ◽  
Patrycja Śniadek ◽  
...  
Keyword(s):  
Simulated Microgravity ◽  
Lab On A Chip ◽  
Human Keratinocytes ◽  
Melanoma Cells ◽  
Short Exposure ◽  
Biological Research ◽  
Cell Physiology ◽  
Caspase Activity ◽  
Chip Technology ◽  
Cells Cultured

The dynamic development of the space industry makes space flights more accessible and opens up new opportunities for biological research to better understand cell physiology under real microgravity. Whereas specialized studies in space remain out of our reach, preliminary experiments can be performed on Earth under simulated microgravity (sµg). Based on this concept, we used a 3D-clinostat (3D-C) to analyze the effect of short exposure to sµg on human keratinocytes HaCaT and melanoma cells A375 cultured on all-glass Lab-on-a-Chip (LOC). Our preliminary studies included viability evaluation, mitochondrial and caspase activity, and proliferation assay, enabling us to determine the effect of sµg on human cells. By comparing the results concerning cells cultured on LOCs and standard culture dishes, we were able to confirm the biocompatibility of all-glass LOCs and their potential application in microgravity research on selected human cell lines. Our studies revealed that HaCaT and A375 cells are susceptible to simulated microgravity; however, we observed an increased caspase activity and a decrease of proliferation in cancer cells cultured on LOCs in comparison to standard cell cultures. These results are an excellent basis to conduct further research on the possible application of LOCs systems in cancer research in space.

scholarly journals Lab-on-a-chip technology and microfluidics

2019 ◽  
pp. 3-36 ◽  
Author(s):  
Antonio Francesko ◽  
Vanessa F. Cardoso ◽  
Senentxu Lanceros-Méndez
Keyword(s):  
Lab On A Chip ◽  
Chip Technology

scholarly journals A Keyword-Based Literature Review Data Generating Algorithm—Analyzing a Field from Scientific Publications

Symmetry ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 903
Author(s):  
Junchao Wang ◽  
Guodong Su ◽  
Chengrui Wan ◽  
Xiwei Huang ◽  
Lingling Sun
Keyword(s):  
Lab On A Chip ◽  
Future Trend ◽  
Research Field ◽  
Levenshtein Distance ◽  
Scientific Publications ◽  
Scientific Review ◽  
The Past ◽  
Communication Engineering ◽  
Chip Technology ◽  
Meta Information

A scientific review is a type of article that summarizes the current state of a specific field, which is crucial for promoting the advancement of our science community. Authors need to read hundreds of research articles to prepare the data and insights for a comprehensive review, which is time-consuming and labor-intensive. In this work, we present an algorithm that can automatically extract keywords from the meta-information of each article and generate the basic data for review articles. Two different fields—communication engineering, and lab on a chip technology—were analyzed as examples. We first built an article library by downloading all the articles from the target journal using a python-based crawler. Second, the rapid automatic keyword extraction algorithm was implemented on the title and abstract of each article. Finally, we classified all extracted keywords into class by calculating the Levenshtein distance between each of them. The results demonstrated its capability of not only finding out how communication engineering and lab on a chip were evolved in the past decades but also summarizing the analytical outcomes after data mining of the extracted keywords. Our algorithm is more than a useful tool for researchers during the preparation of a review article, it can also be applied to quantitatively analyze the past, present and help authors predict the future trend of a specific research field.

scholarly journals Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery

2013 ◽  
Vol 65 (11-12) ◽  
pp. 1626-1663 ◽  
Author(s):  
Goran T. Vladisavljević ◽  
Nauman Khalid ◽  
Marcos A. Neves ◽  
Takashi Kuroiwa ◽  
Mitsutoshi Nakajima ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Scale Up ◽  
Lab On A Chip ◽  
Chip Design

Abstract 1580: Separation of circulating biomarkers by nanoDLD lab-on-a-chip technology

2018 ◽  
Author(s):  
Stacey M. Gifford ◽  
Benjamin H. Wunsch ◽  
Joshua T. Smith ◽  
Navneet Dogra ◽  
Sungcheol Kim ◽  
...  
Keyword(s):  
Lab On A Chip ◽  
Circulating Biomarkers ◽  
Chip Technology

scholarly journals Assessing the Influence of Electric Cues and Conductivity on Pollen Tube Growth via Lab-On-A-Chip Technology

2014 ◽  
Vol 106 (2) ◽  
pp. 574a ◽  
Author(s):  
Carlos G. Agudelo ◽  
Muthukumaran Packirisamy ◽  
Anja Geitmann
Keyword(s):  
Pollen Tube ◽  
Pollen Tube Growth ◽  
Lab On A Chip ◽  
Tube Growth ◽  
Chip Technology
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