scholarly journals A New Century of Pharmacology Is Coming. Prospects for future development in the pharmacology of gastric ulcer models and of gastric acid secretion in experimental animals.

1999 ◽  
Vol 114 (3) ◽  
pp. 141-148 ◽  
Author(s):  
Kazuo WATANABE
Keyword(s):  
Gastric Ulcer ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Future Development ◽  
Experimental Animals

The endoscopic studies on the gastric acid secretion (III) with relation to gastric ulcer

1966 ◽  
Vol 1 (4) ◽  
pp. 54-54
Author(s):  
N. Senda ◽  
H. Inui ◽  
S. Okuda ◽  
T. Itoh ◽  
T. Saegusa ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid

Cimetidine

1979 ◽  
Vol 17 (8) ◽  
pp. 29-32
Keyword(s):  
Duodenal Ulcer ◽  
Gastric Ulcer ◽  
Acid Secretion ◽  
Receptor Antagonist ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Reflux Oesophagitis ◽  
Benign Gastric Ulcer ◽  
Zollinger Ellison Syndrome ◽  
Stomal Ulceration

Cimetidine (Tagamet - SKF) is the first histamine-H2 receptor antagonist in general use. It reduces gastric acid secretion and is marketed for the treatment of duodenal ulcer, benign gastric ulcer, recurrent and stomal ulceration, reflux oesophagitis and Zollinger-Ellison syndrome.

4709 Effect of h. pylori eradication on gastric acid secretion and acid gastro-esophageal reflux in gastric ulcer.

2000 ◽  
Vol 51 (4) ◽  
pp. AB209
Author(s):  
Toshihiko Hayakawa ◽  
Hiroshi Kaneko ◽  
Akihito Kasahara ◽  
Toshihiro Konagaya ◽  
Kazuo Kusugami ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Esophageal Reflux ◽  
H Pylori

Inhibition of gastric acid secretion by omeprazole prevents gastric ulcer relapse caused by interleukin-1ß in rats

1998 ◽  
Vol 114 ◽  
pp. A328
Author(s):  
T. Watanabe ◽  
T. Arakawa ◽  
T. Fukuda ◽  
K. Higuchi ◽  
Y. Fujiwara ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Ulcer Relapse

scholarly journals The preventive effect of Nigella sativa seed on gastric ulcer induced by indomethacin in rat

2020 ◽  
Vol 9 (1) ◽  
pp. 12-19
Author(s):  
Maryam Paseban ◽  
Saeed Niazmand ◽  
Mohammad Soukhtanloo ◽  
Naser Tayyebi Meybodi
Keyword(s):  
Gastric Ulcer ◽  
Acid Secretion ◽  
Protein Content ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Nigella Sativa ◽  
Gastric Ulceration ◽  
Gastric Mucus ◽  
Ulcer Index ◽  
Nigella Sativa Seed

Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as one of the most administrated groups of medications worldwide. Due to the role of NSAIDs in inducing gastric ulceration, their clinical applications are still challenging. Nigella sativa seed is widely used as an herbal medication against gastrointestinal complications. The present experiment was carried out to investigate the impact of N. sativa seed hydro-alcoholic extract on gastric ulcer induced by indomethacin (IND) and to evaluate its possible mechanisms in rat. Methods: This study was performed on 48 male Wistar rats. Acute gastric ulceration was induced by IND (35 mg/kg). N. sativa seed extract (100, 200, 400 mg/kg) and ranitidine (50 mg/kg) were administered orally for five days before the induction ulcer. Ulcer index, gastric acid secretion, gastric mucus content, glutathione (GSH), malondialdehyde (MDA), total hexose, gastric juice protein content were determined on the fifth day. Results: The ulcer index in all groups of N. sativa seed was significantly lower than that of the IND group. N sativa seed considerably decreased MDA and protein content, but increased total thiol, total hexose, and mucus content compared to the IND group. N. sativa seed did not affect gastric acid secretion. Conclusion: These findings were indicative of the gastroprotective effect of N. sativa seed against the IND-induced ulcer, suggesting that it can mainly be exerted through the anti-oxidant activity of the extract as well as its role in stimulating gastric mucus secretion and increasing total hexose in the gastric mucosa.

The Therapeutic Effect of Nigella sativa Seed on Indomethacin-induced Gastric Ulcer in Rats

2020 ◽  
Vol 16 (3) ◽  
pp. 276-283
Author(s):  
Maryam Paseban ◽  
Saeed Niazmand ◽  
Mohammad Soukhtanloo ◽  
Naser T. Meibodi ◽  
Abbasali Abbasnezhad ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Acid Secretion ◽  
Protein Content ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Therapeutic Effect ◽  
Nigella Sativa ◽  
Gastric Mucus ◽  
Ulcer Index ◽  
Nigella Sativa Seed

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain and reduce inflammation. However, gastric complications remain a major problem limiting their clinical usage. This study was carried out to evaluate the therapeutic effect of Nigella sativa seed (N. sativa seed) hydroalcoholic extract on indomethacin-induced gastric ulcer in rats and its possible mechanism. Methods: This study was carried out on forty-eight male Wistar rats. Gastric ulcer was induced by indomethacin (35 mg/kg). N. sativa seed extract (100, 200, and 400 mg/kg) and ranitidine (50 mg/kg) was administered orally for five days after ulcer induction. Ulcer index, gastric acid secretion, gastric mucus content, total thiol, malondialdehyde (MDA), and total hexose, and protein content in gastric juice were determined. Results: The ulcer index in groups of N. sativa seed was significantly lower as compared to indomethacin group. N. sativa seed significantly decreased MDA and protein content, but increased total thiol, total hexose, and mucus content as compared to indomethacin group. N. sativa seed did not affect gastric acid secretion. Conclusion: These findings showed that the gastroprotective effect of N. sativa seed against indomethacin- induced ulcer was mainly exerted by antioxidant activity, stimulation of gastric mucus secretion and also increased total hexose in the gastric mucosa.

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