scholarly journals Effects of maternal exposure to a single dose of kainic acid on the functional development of the brain in the rat.

1994 ◽  
Vol 104 (1) ◽  
pp. 7-18 ◽  
Author(s):  
Mamoru HATA
Keyword(s):  
Single Dose ◽  
Kainic Acid ◽  
Maternal Exposure ◽  
Functional Development ◽  
The Brain

Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release

1990 ◽  
Vol 258 (1) ◽  
pp. E163-E171 ◽  
Author(s):  
G. Katsuura ◽  
A. Arimura ◽  
K. Koves ◽  
P. E. Gottschall
Keyword(s):  
Kainic Acid ◽  
Adrenocorticotropic Hormone ◽  
Preoptic Area ◽  
Interleukin 1 ◽  
Prostaglandin E ◽  
Lamina Terminalis ◽  
Interleukin 1 Beta ◽  
Plasma Acth ◽  
Organum Vasculosum ◽  
The Brain

Intravenous administration of recombinant human interleukin 1 beta (IL-1 beta, 1 micrograms/100 g body wt) resulted in a marked elevation of plasma adrenocorticotropic hormone (ACTH) levels, with peak levels at 10 min, in conscious unrestrained rats. One week after the placement of a lesion by radiofrequency or microinjection of kainic acid in the organum vasculosum of lamina terminalis (OVLT) but not in subfornical organ, ACTH response to intravenous IL-1 beta was enhanced, whereas both radiofrequency-induced lesion and kainic acid in the preoptic area (POA) suppressed the response. Indomethacin or a prostaglandin E (PGE) antagonist microinjected into the OVLT or POA suppressed or abolished the response. On the other hand, PGE, but not PGD2, microinjected into the POA increased plasma ACTH levels. These results suggest an important role for the OVLT, which lacks blood-brain barrier, as a possible site of entry of blood-borne IL-1 beta into the brain and for the POA, which may contain the neurons required for the response. Involvement of PGE in the OVLT and POA in the ACTH response to intravenous IL-1 beta is also suggested.

Precocious ovarian stimulation following hypothalamic and amygdaloid lesions in rats

1960 ◽  
Vol 198 (2) ◽  
pp. 381-385 ◽  
Author(s):  
Mildred Elwers ◽  
Vaughn Critchlow
Keyword(s):  
Ovarian Stimulation ◽  
Histological Study ◽  
Amygdaloid Complex ◽  
Female Rats ◽  
Gonadotropin Secretion ◽  
Functional Development ◽  
Electrolytic Lesions ◽  
Basal Septum ◽  
The Brain ◽  
Hypothalamic Mechanism

The effects of neural lesions on the functional development of the reproductive system were studied in prepubertal female rats. Small electrolytic lesions were placed bilaterally in 66 female rats at 18–20 days of age; 42 littermates served as controls, and 7 rats were blank-operated. All animals were weighed two to three times a week and examined daily for vaginal opening. At 33 days of age the uteri, ovaries and adrenals were weighed and prepared for histological study. All brains were examined histologically for lesion localization. Lesions in the anterior hypothalamus or in the medial portion of the amygdaloid complex were associated with precocious ovarian stimulation. With the exception of one lesion in the basal septum and one in caudate-putamen, bilaterally symmetrical lesions in other parts of the brain and asymmetrical lesions have been ineffective. These results are compatible with an anterior hypothalamic mechanism involved in the inhibition of gonadotropin secretion and suggest the inclusion of the medial portion of the amygdaloid complex in this mechanism.

Changes in the brain protein levels following administration of kainic acid

2001 ◽  
Vol 22 (10) ◽  
pp. 2086-2091 ◽  
Author(s):  
Kurt Krapfenbauer ◽  
Michael Berger ◽  
Gert Lubec ◽  
Michael Fountoulakis
Keyword(s):  
Kainic Acid ◽  
Brain Protein ◽  
Protein Levels ◽  
The Brain
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