scholarly journals Acidified aspirin-induced gastric lesion in rats with hepatic cirrhosis produced by N-nitrosodiethylamine or carbon tetrachloride. Effect of aldioxa on gastric lesions.

1994 ◽  
Vol 103 (3) ◽  
pp. 111-120
Author(s):  
Masayuki UCHIDA ◽  
Hiroki HAMURA ◽  
Satoshi TAKAGI ◽  
Yuji NOGUCHI ◽  
Hiroko SHIBATA ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Hepatic Cirrhosis ◽  
Gastric Lesion ◽  
Gastric Lesions

Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Vanessa Mba Matah Marthe ◽  
Gilbert Ateufack ◽  
Marius Mbiantcha ◽  
William Yousseu Nana ◽  
Albert Donatien Atsamo ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Gastric Lesion ◽  
Stem Bark ◽  
Male Rats ◽  
Gastric Ulcers ◽  
Gastric Lesions ◽  
Mucus Production ◽  
Antisecretory Activity ◽  
Antisecretory Effect ◽  
Pylorus Ligation

AbstractObjectivesIn African traditional medicine, Distemonanthus benthamianus (Caesalpiniaceae) is used to treat many diseases including gastric ulcers. We evaluated in this study, the cytoprotective and antisecretory properties of the methanolic extract of the stem bark of this plant using different technics of gastric lesion induction.MethodsCytoprotective and antisecretory activity of the methanolic extract of D. benthamianus stem bark was evolved through six methods of gastric lesion induction in experimental Wistar male rats (150–200 g): (1) gastric lesions induced by HCl/ethanol, (2) gastric lesions induced by Indomethacin- HCl/ethanol, (3) gastric lesion induced by Indomethacin, (4) gastric lesions induced by Pylorus ligation, (5) gastric lesions induced by histamine-Pylorus ligation, (6) gastric lesions induced by carbachol-Pylorus ligation. Mucus and gastric mucosal ulceration were evaluated. pH, gastric volume, and acidity were quantified in all pylorus ligation induction technics. Nitric oxide (NO) level was determined in indomethacin induced gastric ulcers.ResultsAt different doses (125, 250 and 500 mg/kg), extract reduced significantly the ulcer index. In all models used, that is 100.00% with HCl/ethanol; 100.00% with HCl/ethanol/indomethacin; 95.70% with Indomethacin; 74.79% with pylorus ligation, 95.94% histamine-Pylorus ligation, 99.54% carbachol-Pylorus ligation at the highest dose of 500 mg/kg. The lesion formation reduces in all the methods used followed by a significant increase of mucus production. The pylorus ligation technic revealed that the extract has an antisecretory activity.ConclusionsThe methanolic extract of D. benthamianus stem bark has both cytoprotective and antisecretory effects. This extract exerts its antisecretory effect trough cholinergic and histaminergic pathways.

scholarly journals Effects of a dietary supplement on gastric ulcer number and severity in exercising horses1

2018 ◽  
Vol 2 (2) ◽  
pp. 119-124
Author(s):  
Alysia L Conner ◽  
Amanda J Davis ◽  
Cheryl A Porr
Keyword(s):  
Gastric Ulcer ◽  
Dietary Supplement ◽  
Fixed Effects ◽  
Gastric Lesion ◽  
Gastric Ulcers ◽  
Experimental Unit ◽  
Adaptation Period ◽  
Feeding Period ◽  
Gastric Lesions ◽  
Dependent Variables

Abstract This study evaluated the effect of a dietary supplement on the treatment of equine gastric ulcer syndrome (EGUS). Gastroscopy was performed on university riding horses of mixed breeds at two locations and only horses exhibiting gastric ulcers were selected to participate in this study (location A, n = 13; location B, n = 15). Gastric ulcer severity was assessed using two different methods depending on location before treatment (Pre). After gastroscopy, horses were fed the supplement in addition to their regular diet for 44 d (14-d adaptation period followed by 30-d feeding period). All horses were subjected to gastroscopy again at the end of the feeding period (Post) to evaluate changes in gastric lesions. Statistical analysis was performed using SAS. Individual horses were the experimental unit with dependent variables including severity and number of gastric ulcers. At location A, dependent variable included severity of gastric lesions with fixed effects of time (Pre and Post) and location (stall or pasture). For location B, dependent variables included severity and number of gastric lesions with fixed effects of time. Severity of gastric ulcers decreased at both locations in horses following the feeding period. Gastric lesion scores decreased from 2.2990 to 1.3760 (P = 0.0015) at location A and gastric lesion severity from 3.8000 to 2.5667 (P = 0.0322) at location B. No differences were found in gastric lesion scores at location A between horses housed in stalls or pastures (1.8750 and 1.8000; P = 0.7783). The number of gastric ulcers observed at location B were similar Pre and Post treatment (3.4667 and 3.5333; P = 0.8363). There were no changes in body condition score (P ≥ 0.2607), BW (P ≥ 0.4551), or behavior at either location. Results suggest that oral supplementation may decrease severity of gastric ulcers in horses participating in university riding programs.

scholarly journals Acute renal failure induced by carbon tetrachloride in rats with hepatic cirrhosis

2008 ◽  
Vol 7 (4) ◽  
pp. 331-338 ◽  
Author(s):  
Fernando Jaramillo-Juárez ◽  
María Luisa Rodríguez-Vázquez ◽  
Ana Rosa Rincón-Sánchez ◽  
María Consolación Martínez ◽  
Genaro G. Ortiz ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Carbon Tetrachloride ◽  
Hepatic Cirrhosis

Gastroprotective Effect of Fructus Evodiae Water Extract on Ethanol-Induced Gastric Lesions in Rats

2006 ◽  
Vol 34 (06) ◽  
pp. 1027-1035 ◽  
Author(s):  
Xiao Yu ◽  
Da-Zheng Wu ◽  
Jian-Ye Yuan ◽  
Rong-Rong Zhang ◽  
Zhi-Bi Hu
Keyword(s):  
Gastric Lesion ◽  
Ex Vivo ◽  
Water Extract ◽  
Mucosal Barrier ◽  
Dependent Manner ◽  
Gastric Lesions ◽  
Gastric Mucosal Lesions ◽  
Nitrate And Nitrite ◽  
Dose Dependent ◽  
Lesion Index

Fructus Evodiae is a widely used herbal medicine with anti-inflammatory and analgetic activities in China. The present study was designed to investigate the effect of Fructus Evodiae water extract (FE) on ethanol-induced gastric lesions in rats. Three hours before ethanol challenge, animals were intraperitoneally treated with FE (424.8 mg/kg, 141.6 mg/kg, and 47.6 mg/kg). Subsequently, we employed ex-vivo chamber technique to examine the effect of FE on gastric transmucosal potential difference (PD) changes. NOx (nitrate and nitrite) in gastric perfusate and gastric lesion index of whole glandular stomach were determined by intubation. The results showed that FE dose-dependently accelerated the recovery of PD reduction by ethanol, and increased NOx production in gastric perfusate. FE also inhibited gastric lesion formation in a dose-dependent manner. These results suggested that FE prevented ethanol-induced gastric mucosal lesions by strengthening the mucosal barrier integrity and increasing gastric mucosal nitric oxide (NO) synthesis.

l-Theanine prevents carbon tetrachloride-induced liver fibrosis via inhibition of nuclear factor κB and down-regulation of transforming growth factor β and connective tissue growth factor

2015 ◽  
Vol 35 (2) ◽  
pp. 135-146 ◽  
Author(s):  
JE Pérez-Vargas ◽  
N Zarco ◽  
P Vergara ◽  
M Shibayama ◽  
J Segovia ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Hepatic Cirrhosis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Nuclear Factor Κb ◽  
Tissue Growth ◽  
Nuclear Factor

Here we evaluated the ability of l-theanine in preventing experimental hepatic cirrhosis and investigated the roles of nuclear factor-κB (NF-κB) activation as well as transforming growth factor β (TGF-β) and connective tissue growth factor (CTGF) regulation. Experimental hepatic cirrhosis was established by the administration of carbon tetrachloride (CCl4) to rats (0.4 g/kg, intraperitoneally, three times per week, for 8 weeks), and at the same time, adding l-theanine (8.0 mg/kg) to the drinking water. Rats had ad libitum access to water and food throughout the treatment period. CCl4 treatment promoted NF-κB activation and increased the expression of both TGF-β and CTGF. CCl4 increased the serum activities of alanine aminotransferase and γ-glutamyl transpeptidase and the degree of lipid peroxidation, and it also induced a decrease in the glutathione and glutathione disulfide ratio. l-Theanine prevented increased expression of NF-κB and down-regulated the pro-inflammatory (interleukin (IL)-1β and IL-6) and profibrotic (TGF-β and CTGF) cytokines. Furthermore, the levels of messenger RNA encoding these proteins decreased in agreement with the expression levels. l-Theanine promoted the expression of the anti-inflammatory cytokine IL-10 and the fibrolytic enzyme metalloproteinase-13. Liver hydroxyproline contents and histopathological analysis demonstrated the anti-fibrotic effect of l-theanine. In conclusion, l-theanine prevents CCl4-induced experimental hepatic cirrhosis in rats by blocking the main pro-inflammatory and pro-fibrogenic signals.

Stress-Induced Gastric Lesions in Mice

1965 ◽  
Vol 16 (3) ◽  
pp. 941-946 ◽  
Author(s):  
John D. Frisone ◽  
Walter B. Essman
Keyword(s):  
Food Deprivation ◽  
Gastric Lesion ◽  
Gastric Tissue ◽  
Gastric Lesions ◽  
Gastric Pathology ◽  
Induced Stress ◽  
Food Retention ◽  
And Control

Groups of light (13-21 gm.) and heavier (22-30 gm.) mice were subdivided and either immobilized for 48 hr. (Experimental) or just food deprived for the same period (Control). The stomachs were removed, food contents noted, and the gastric tissue was examined for lesions and rated for the severity of pathology Experimental and control Ss differed significantly only with respect to the amount of food contained in the stomach and not with respect to the rated severity of the gastric lesion; a decrease in the severity of gastric pathology and a lowered incidence of gastric pathology emerged as a function of increased weight and food retention. It was apparent that immobilization-induced stress contributed little more to the incidence and severity of gastric lesions in mice than did food deprivation alone.

scholarly journals Evidence of Helicobacter spp. in Saliva and Gastric Mucosa of Domestic Dogs in the Central Region of Rio Grande do Sul, Brazil

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Daniel D. Guerra Segundo ◽  
Camila B. E. Mello ◽  
Juliana F. Cargnelutti ◽  
Mariana M. Flores ◽  
Luís F. Pedrotti ◽  
...  
Keyword(s):  
Central Region ◽  
Gastric Lesion ◽  
Rio Grande ◽  
Domestic Dogs ◽  
Occurrence Rate ◽  
Rio Grande Do Sul ◽  
Gastric Lesions ◽  
Gastric Diseases ◽  
Phylogenetic Groups ◽  
H Pylori

Helicobacter pylori is a spiral-shaped bacterium, which plays a role in the aetiology of gastric diseases in humans. Non-H. pylori Helicobacter (NHPH) species naturally colonise the stomach of animals and also induce gastric lesions in humans, highlighting their zoonotic importance. We evaluated the gastric bacterial colonisation density and gastric lesions and sought to identify the main phylogenetic groups of the Helicobacter spp. obtained from dogs in the central region of Rio Grande do Sul, Brazil, with this study aiming to investigate the occurrence of Helicobacter spp. in saliva and gastric samples from these dogs. This study included 35 dogs and used analysis such as cytology, histopathology, PCR, rapid urease testing, and phylogenetic analysis. Of the dogs, 94.3% were positive for Helicobacter spp., and these bacteria were present in the stomach of 32 dogs and saliva of eight. Respectively, eight, 15, and nine dogs had mild, moderate, and severe colonisation. Lymphocytic-plasmacytic infiltrate was the main gastric lesion. However, the presence of Helicobacter and the density appeared to be unrelated to the gastric lesions. The samples possessed a high nucleotide identity with remarkably similar sequences among some of the species of NHPH such as H. heilmannii s.s., H. salomonis, H. felis, and H. bizzozeronii. The saliva of domestic dogs, even of those who appear clinically healthy, can cause Helicobacter infection in humans and other animals, with, in these dogs, increased density, occurrence rate, and predominance of NHPH of zoonotic importance being found in the stomach with a lower occurrence of Helicobacter spp. in the saliva.

scholarly journals Gastroprotective Activity of Sterculia striata A. St. Hil. & Naudin (Malvaceae) in Rodents

2012 ◽  
Vol 67 (3-4) ◽  
pp. 163-171
Author(s):  
Joubert A. Sousa ◽  
Irisdalva S. Oliveira ◽  
Francilene V. Silva ◽  
Danielly A. Costa ◽  
Mariana H. Chaves ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Methyl Ester ◽  
Gastric Secretion ◽  
Catalase Activity ◽  
Gastric Lesion ◽  
Ischemia Reperfusion ◽  
Ethanolic Extract ◽  
Antioxidant Compounds ◽  
Gastric Lesions ◽  
Gastroprotective Activity

The Sterculia striata ethanolic extract (Ss-EtOH) inhibited gastric lesions induced by ethanol, HCl/ethanol, and ischemia/reperfusion, but not those induced by indomethacin, and did not alter the gastric secretion. Ss-EtOH restored the catalase activity and content of nonprotein sulfhydryl groups in the stomach of mice treated with ethanol. The gastroprotection induced by Ss-EtOH in the ethanol-induced gastric lesion model was abolished by NG-nitro- L-arginine methyl ester (L-NAME) pretreatment, suggesting the involvement of nitric oxide and antioxidant compounds, but not prostaglandins, in this activity. Lupeol obtained from Ss-EtOH promoted gastroprotection as well as the extract at the same dose, and it must therefore contribute to the observed effects

scholarly journals Effect of EDRF on gastric lesions: inhibition of 0.6N HCl-induced gastric lesion by nitric oxide

1989 ◽  
Vol 49 ◽  
pp. 121
Author(s):  
Hisato Kitagawa ◽  
Fumiyo Takeda ◽  
Hideyuki Nishiwaki ◽  
Hiroshi Kohei
Keyword(s):  
Nitric Oxide ◽  
Gastric Lesion ◽  
Gastric Lesions

Effects of 1-O-hexyl-2,3,5-trimethylhydroquinone on carbon tetrachloride-induced hepatic cirrhosis in rats

2010 ◽  
Vol 40 (6) ◽  
pp. 613-621 ◽  
Author(s):  
Jun An ◽  
Guo-Gang Feng ◽  
Lei Huang ◽  
Tsuyoshi Kurokawa ◽  
Toshiaki Nonami ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Hepatic Cirrhosis
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