scholarly journals Inhibitory action of E3810 on H+, K+-ATPase and gastric acid secretion in vitro.

1993 ◽  
Vol 102 (6) ◽  
pp. 389-397 ◽  
Author(s):  
Hideaki FUJISAKI ◽  
Kiyoshi OKETANI ◽  
Hisashi SHIBATA ◽  
Manabu MURAKAMI ◽  
Masatoshi FUJIMOTO ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Inhibitory Action

scholarly journals Inhibitory action of E3810, a new H+-K+ ATPase inhibitor, on H+-K+ ATPase anil gastric acid secretion in vitro

1989 ◽  
Vol 49 ◽  
pp. 196
Author(s):  
Hideaki Fujisaki ◽  
Kiyoshi Oketani ◽  
Hisashi Shibata ◽  
Manabu Murakami ◽  
Tsuneo Wakabayashi ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Inhibitory Action ◽  
Atpase Inhibitor

An hypothesis for discovery of inhibitors of gastric acid secretion

1964 ◽  
Vol 207 (3) ◽  
pp. 613-618 ◽  
Author(s):  
Marian E. LeFevre ◽  
Edmund J. Gohmann ◽  
Warren S. Rehm
Keyword(s):  
Carbonic Anhydrase ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Electrical Resistance ◽  
Inhibitory Action ◽  
Potential Difference ◽  
Ammonium Ions ◽  
Working Hypothesis

Davenport discovered that thiocyanate inhibits gastric acid secretion. The original working hypothesis, that this action of thiocyanate is due to inhibition of carbonic anhydrase, was successful in stimulating further work but is now no longer tenable. We propose a new working hypothesis according to which the inhibitory action is dependent on the presence of a nitrogen with a pair of unshared electrons. This hypothesis was tested by studying the effects of nitrite, cyanate, and ammonium ions on the in vitro frog's stomach. It was found that the addition of these compounds to the nutrient side reversibly inhibits H+ secretion in the same concentration range as that found for thiocyanate, i.e., 0.5–10 mm. Reduction of the H+ rate to approximately zero was associated with an increase in the transmucosal potential difference and electrical resistance to levels characteristic of the resting stomach. Acetate and nitrate in the same and higher concentrations did not inhibit the H+ rate. The hypothesis has been fruitful in that three new gastric inhibitors have been discovered, and it is hoped that it will be successful in stimulating much further work before it too becomes untenable.

Effect of caffeic acid phenethyl ester on gastric acid secretion in vitro

2005 ◽  
Vol 521 (1-3) ◽  
pp. 139-143 ◽  
Author(s):  
Francesca Borrelli ◽  
Inmaculada Posadas ◽  
Raffaele Capasso ◽  
Gabriella Aviello ◽  
Valeria Ascione ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

Radioreceptor and biological characterization of cholecystokinin and gastrin in the chicken

1984 ◽  
Vol 246 (3) ◽  
pp. G296-G304
Author(s):  
S. R. Vigna
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Amylase Secretion ◽  
Physiological Regulation ◽  
Chicken Brain ◽  
Specific Radioimmunoassay ◽  
Cck Receptor Antagonist

Radioimmunoassay, radioreceptor assays, and bioassays were used to demonstrate that chicken brain and antrum extracts contain cholecystokinin (CCK)-like and gastrinlike peptides, respectively. C-terminal-specific radioimmunoassay of partially purified chicken CCK and gastrin gave dilution curves parallel to those of the mammalian peptides. Mouse cerebral cortical and rat pancreatic membrane radioreceptor assays were used to differentiate CCK- from gastrinlike peptides on the basis of the different CCK versus gastrin specificities of the two receptors. Confirmation of the biological activity of chicken brain CCK was obtained by stimulation of amylase secretion from rat pancreatic lobules in vitro. The specificity of this response was demonstrated by the inhibition of chicken CCK-stimulated amylase secretion by the specific CCK receptor antagonist dibutyryl cGMP. Chicken antral gastrin stimulated gastric acid secretion from the rat stomach in vivo. In contrast to previous hypotheses, it is proposed that chickens have significant amounts of an antral gastrinlike peptide and that therefore it is possible that gastrin is involved in the physiological regulation of gastric acid secretion in chickens.

scholarly journals The mechanism of inhibitory action of secretin on gastric acid secretion in conscious rats.

1995 ◽  
Vol 488 (2) ◽  
pp. 501-508 ◽  
Author(s):  
K Shimizu ◽  
P Li ◽  
K Y Lee ◽  
T M Chang ◽  
W Y Chey
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Inhibitory Action ◽  
Conscious Rats

scholarly journals Central Site of Inhibitory Action of Bombesin on Gastric Acid Secretion in Rats

1987 ◽  
Vol 45 (2) ◽  
pp. 129-133
Author(s):  
Yasunobu OKUMA ◽  
Kunihiko YOKOTANI ◽  
Yoshitsugu OSUMI
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Inhibitory Action
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