scholarly journals Beneficial Effects of Heart Rate Reduction on Cardiac Mechanics and Energetics in Patients With Left Ventricular Dysfunction

1999 ◽  
Vol 63 (12) ◽  
pp. 957-964 ◽  
Author(s):  
Toshiro Shinke ◽  
Motoshi Takeuchi ◽  
Hideyuki Takaoka ◽  
Mitsuhiro Yokoyama
Keyword(s):  
Heart Rate ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Cardiac Mechanics ◽  
Left Ventricular ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Beneficial Effects

Role of Heart Rate Reduction in the Management of Myocarditis

2018 ◽  
Vol 24 (3) ◽  
pp. 365-378 ◽  
Author(s):  
Chen Guang-Yi ◽  
Ge Li-Sha ◽  
Li Yue-Chun
Keyword(s):  
Heart Rate ◽  
Nitrosative Stress ◽  
Ventricular Remodeling ◽  
Animal Experiments ◽  
Viral Myocarditis ◽  
Protective Effects ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Beneficial Effects ◽  
Biological Technique

The morbidity of myocarditis demonstrates an upward tendency by years, is commonly defined as the inflammation of myocytes and is caused by multiple factors. With the development of the molecular biological technique, great breakthroughs in the diagnosis and understanding of pathophysiological mechanisms of myocarditis have recently been achieved. Several questions remain unresolved, however, including standard treatment approaches to myocarditis, which remain controversial and ambiguous. Heart rate, as an independent risk factor, has been shown to be related to cardiac disease. Recent studies also show that the autonomic nervous system is involved in immunomodulatory myocarditis processes. Heart rate reduction treatment is recommended in myocarditis based on a number of animal experiments and clinical trials. It is possible that heart rate-lowering treatments can help to attenuate the inflammatory response and myocyte injury and reverse ventricular remodeling. However, how to execute the protective effects of heart rate reduction on myocarditis is still not clear. In this review, we discuss the pathogenesis and pathophysiological process of viral myocarditis and propose heart rate lowering as a therapeutic target for myocarditis, especially in light of the third-generation β-blockade carvedilol and funny channel blocker ivabradine. We also highlight some additional beneficial effects of such heart rate reduction agents, including anti-inflammatory, antioxidation, anti-nitrosative stress, anti-fibrosis and antiapoptosis properties.

scholarly journals Elevated resting heart rate is a marker of subclinical left ventricular dysfunction in hodgkin lymphoma survivors

2021 ◽  
Vol 35 ◽  
pp. 100830
Author(s):  
Julius C. Heemelaar ◽  
Augustinus D.G. Krol ◽  
Marloes Louwerens ◽  
Saskia L.M.A. Beeres ◽  
Eduard R. Holman ◽  
...  
Keyword(s):  
Heart Rate ◽  
Hodgkin Lymphoma ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Resting Heart Rate ◽  
Lymphoma Survivors

scholarly journals The beneficial effects of tadalafil on left ventricular dysfunction in doxorubicin-induced cardiomyopathy

2013 ◽  
Vol 62 (2) ◽  
pp. 110-116 ◽  
Author(s):  
Zhe Jin ◽  
Jian Zhang ◽  
Huilan Zhi ◽  
Bingzhe Hong ◽  
Shuying Zhang ◽  
...  
Keyword(s):  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Beneficial Effects
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