scholarly journals High-energy Phosphate Metabolism of the Myocardium in Normal Subjects and Patients with Various Cardiomyopathies. The study using ECG gated MR spectroscopy with a localization technique.

1992 ◽  
Vol 56 (6) ◽  
pp. 620-626 ◽  
Author(s):  
YOSHIAKI MASUDA ◽  
YUKIO TATENO ◽  
HIROO IKEHIRA ◽  
TAKAYUKI HASHIMOTO ◽  
FUMIO SHISHIDO ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Normal Subjects ◽  
High Energy ◽  
Phosphate Metabolism ◽  
High Energy Phosphate ◽  
Localization Technique ◽  
High Energy Phosphate Metabolism

High-energy phosphate metabolism in a neonatal model of hydrocephalus before and after shunting

1994 ◽  
Vol 81 (4) ◽  
pp. 544-553 ◽  
Author(s):  
Marcia C. da Silva ◽  
James M. Drake ◽  
Claude Lemaire ◽  
Albert Cross ◽  
Ursula I. Tuor
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Mr Spectroscopy ◽  
High Energy ◽  
Resonance Spectroscopy ◽  
Phosphate Metabolism ◽  
Energy Index ◽  
High Energy Phosphate ◽  
High Energy Phosphate Metabolism ◽  
The Impact

✓ The authors studied the effects of hydrocephalus on the high-energy phosphate metabolism of the brain and the impact of ventriculoperitoneal (VP) shunting on these changes in an experimental model of hydrocephalus. High-energy phosphate metabolism was analyzed using in vivo magnetic resonance (MR) imaging and 31P MR spectroscopy. Hydrocephalus was produced in 34 1-week-old kittens by cisternal injection of 0.05 ml of a 25% kaolin solution. Sixteen litter mates were used as controls. A VP shunt with a distal slit valve was implanted in 17 of the 34 hydrocephalic animals 10 days after induction of hydrocephalus. Both MR imaging and 31P MR spectroscopy were obtained 1 and 3 weeks after either kaolin or distilled water injection. Untreated hydrocephalic animals had marked dilatation of the lateral ventricles and periventricular edema. Magnetic resonance spectroscopy showed a significant decrease in the energy index ratio of phosphocreatine (PCR): inorganic phosphate (PI) and an increase in the PI:adenosine triphosphate (ATP) ratio. There was a direct correlation between the decrease in the energy index and ventricular size. Compared with preoperative scans, shunted animals showed no periventricular edema, and the ventricles decreased in size. Also, PCR:PI and PI:ATP ratios were within the levels of controls. This study suggests that neonatal hydrocephalus results in a mild hypoxic/ischemic insult that is treatable by VP shunting.

Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia

1995 ◽  
Vol 16 (6) ◽  
pp. 973-975 ◽  
Author(s):  
Jay W. Pettegrew ◽  
William E. Klunk ◽  
Emanuel Kanal ◽  
Kanagasabai Panchalingam ◽  
Richard J. McClure
Keyword(s):  
High Energy ◽  
Membrane Phospholipid ◽  
Phosphate Metabolism ◽  
High Energy Phosphate ◽  
Brain Membrane ◽  
High Energy Phosphate Metabolism
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