scholarly journals Effect of cyclic GMP and sulfhydryl on prostacyclin production by human vascular endothelial cells.

1991 ◽  
Vol 55 (6) ◽  
pp. 643-647 ◽  
Author(s):  
KYOCHIRO KOBAYASHI ◽  
TAKEO TOYODA ◽  
SYOHEI SAWADA ◽  
KAORU SHIRAI ◽  
KATSUMI YAMAMOTO ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cyclic Gmp ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Prostacyclin Production

Human serum stimulates endothelin-1 synthesis more potently than prostacyclin production by cultured vascular endothelial cells

Life Sciences ◽  
1991 ◽  
Vol 49 (8) ◽  
pp. 603-609 ◽  
Author(s):  
Ari Ristimäki ◽  
Risto Renkonen ◽  
Outi Saijonmaa ◽  
Olavi Ylikorkala ◽  
Lasse Viinikka
Keyword(s):  
Endothelial Cells ◽  
Human Serum ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Endothelin 1 ◽  
Prostacyclin Production

YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway

2003 ◽  
Vol 66 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Hun-Kung Hsu ◽  
Shu-Hui Juan ◽  
Pei-Yin Ho ◽  
Yu-Chih Liang ◽  
Chien-Huang Lin ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cyclic Gmp ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial

scholarly journals Implication of cyclic GMP and sulfhydryl radicals in prostacyclin generation of human vascular endothelial cells.

1989 ◽  
Vol 20 (6) ◽  
pp. 545-552
Author(s):  
Kyoichiro KOBAYASHI ◽  
Takeo TOYODA ◽  
Syohei SAWADA ◽  
Kaoru SHIRAI ◽  
Katsumi YAMAMOTO ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cyclic Gmp ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial

Effects of Homocysteine and Related Compounds on Prostacyclin Production by Cultured Human Vascular Endothelial Cells

1993 ◽  
Vol 70 (06) ◽  
pp. 1047-1052 ◽  
Author(s):  
Jian Wang ◽  
Nicholas P B Dudman ◽  
David E L Wilcken
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Calf Serum ◽  
Consistent Difference ◽  
Vascular Endothelial ◽  
Intravascular Thrombosis ◽  
Increased Risk ◽  
Related Compounds ◽  
Prostacyclin Production ◽  
Cells Cultured

SummaryElevated plasma homocysteine is associated with an increased risk of intravascular thrombosis. Platelet aggregation and thrombosis are inhibited by prostacyclin produced by the vascular endothelium. Our aim was to investigate whether homocysteine and related metabolites inhibit endothelial prostacyclin production. We used a radioimmunoassay for 6-ketoprostaglandin-F1α to assay medium which had been in contact with confluent cultured endothelial cells. In medium containing 20% human serum, endothelial prostacyclin production was not specifically inhibited by homocysteine, S-adenosylhomocysteine or protein-bound homocysteine. Further, there was no consistent difference in prostacyclin production by cells cultured in medium containing sera from homocystinuria patients, compared with medium containing normal healthy sera. We conclude that vascular disorder in homocystinuria is unlikely to result from effects of homocysteine or related metabolites on endothelial prostacyclin production. By contrast, S-adenosylhomocysteine and protein-bound homocysteine specifically inhibited prostacyclin production by cells cultured in medium containing 20% fetal calf serum.

Prostacyclin: Production by Vascular Endothelium and Effects on Platelet Aggregation

1979 ◽  
Author(s):  
S. Moncada ◽  
S. Bunting
Keyword(s):  
Endothelial Cells ◽  
Arachidonic Acid ◽  
Platelet Aggregation ◽  
Vascular Endothelium ◽  
Vascular Endothelial Cells ◽  
Specific Inhibitor ◽  
Inhibitory Effect ◽  
Vascular Endothelial ◽  
Prostacyclin Production

The inhibitory effect of vascular endothelial cells on platelet aggregation is due to their ability to release prostacyclin. The existence of an ADPase has been confirmed in endothelial cells but this enzymes does not seem to be related to the anti-aggregating properties of vascular endothelium. In vitro, the release of prostacyclin by humand and rabbit endothelial cells persists after several subcultures. The production of PGI2 can be demonstrated by its inhibition by aspirin-like drugs or 15-hydroperoxy arachidonic acid (a specific inhibitor of PGI2 synthesis). Moreover, the antiaggregating activity is antagonised by an antibody to 5,6 dihydro prostacyclin which cross reacts and neutralises prostacyclin.

Human Milk Stimulates Prostacyclin Production by Cultured Human Vascular Endothelial Cells*

1991 ◽  
Vol 72 (3) ◽  
pp. 623-627 ◽  
Author(s):  
ARI RISTIMÄKI ◽  
OLAVI YLIKORKALA ◽  
KRISTINA PESONEN ◽  
JAAKKO PERHEENTUPA ◽  
LASSE VIINIKKA
Keyword(s):  
Endothelial Cells ◽  
Human Milk ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Prostacyclin Production

scholarly journals Interferon enhances prostacyclin production by cultured vascular endothelial cells.

1984 ◽  
Vol 73 (1) ◽  
pp. 251-257 ◽  
Author(s):  
A Eldor ◽  
R Fridman ◽  
I Vlodavsky ◽  
E Hy-Am ◽  
Z Fuks ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Prostacyclin Production
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