scholarly journals A quantitative analysis of reservoir function of the human pulmonary "venous" system for the left ventricle.

1986 ◽  
Vol 50 (3) ◽  
pp. 222-231 ◽  
Author(s):  
MASAHIRO GOTO ◽  
MICHIO ARAKAWA ◽  
TAKAHIKO SUZUKI ◽  
TSUTOMU TANAKA ◽  
HIROMICHI MIYAMOTO ◽  
...  
Author(s):  
P. Boesiger ◽  
G. McKinnon ◽  
O. Hess ◽  
H. P. Krayenbühl ◽  
S. E. Maier ◽  
...  

2011 ◽  
Vol 301 (6) ◽  
pp. H2362-H2371 ◽  
Author(s):  
Rochus K. Voeller ◽  
Abdulhameed Aziz ◽  
Hersh S. Maniar ◽  
Nneka N. Ufere ◽  
Ajay K. Taggar ◽  
...  

Increased right atrial (RA) and ventricular (RV) chamber volumes are a late maladaptive response to chronic pulmonary hypertension. The purpose of the current investigation was to characterize the early compensatory changes that occur in the right heart during chronic RV pressure overload before the development of chamber dilation. Magnetic resonance imaging with radiofrequency tissue tagging was performed on dogs at baseline and after 10 wk of pulmonary artery banding to yield either mild RV pressure overload (36% rise in RV pressure; n = 5) or severe overload (250% rise in RV pressure; n = 4). The RV free wall was divided into three segments within a midventricular plane, and circumferential myocardial strain was calculated for each segment, the septum, and the left ventricle. Chamber volumes were calculated from stacked MRI images, and RA mechanics were characterized by calculating the RA reservoir, conduit, and pump contribution to RV filling. With mild RV overload, there were no changes in RV strain or RA function. With severe RV overload, RV circumferential strain diminished by 62% anterior ( P = 0.04), 42% inferior ( P = 0.03), and 50% in the septum ( P = 0.02), with no change in the left ventricle ( P = 0.12). RV filling became more dependent on RA conduit function, which increased from 30 ± 9 to 43 ± 13% ( P = 0.01), than on RA reservoir function, which decreased from 47 ± 6 to 33 ± 4% ( P = 0.04), with no change in RA pump function ( P = 0.94). RA and RV volumes and RV ejection fraction were unchanged from baseline during either mild ( P > 0.10) or severe RV pressure overload ( P > 0.53). In response to severe RV pressure overload, RV myocardial strain is segmentally diminished and RV filling becomes more dependent on RA conduit rather than reservoir function. These compensatory mechanisms of the right heart occur early in chronic RV pressure overload before chamber dilation develops.


Folia Medica ◽  
2018 ◽  
Vol 60 (2) ◽  
pp. 226-233
Author(s):  
Alexandar A. Iliev ◽  
Georgi N. Kotov ◽  
Boycho V. Landzhov ◽  
Lazar S. Jelev ◽  
Iva N. Dimitrova ◽  
...  

Abstract Background: The growth of the heart during the foetal and early postnatal development takes places mainly due to hyperplasia. The late postnatal development is characterised by cardiomyocytic hypertrophy in response to normal physiological mechanisms and increased load. To study the cell size most authors measure the diameter either directly or indirectly. Aim: The aim of the present study was to make a comparative quantitative analysis of the postnatal changes observed in the left and right ventricles in rat by evaluating the changes in three morphometric parameters – thickness of the free wall, transverse section of the cardiomyocytes and cardiomyocytic density in the left ventricle and right ventricle. Materials and methods: In the present study, we used histological material from the hearts of 15 male Wistar rats, distributed in five groups aged 2 weeks, 1 month, 3 months, 6 months and 12 months, respectively. Results: In both ventricles, the wall thickness and the transverse section of the cardiomyocytes increased with age, while the cardiomyocytic density decreased. Changes were identical in both ventricles; however, they were more dynamic and pronounced in the left ventricle. Conclusions: The studied morphometric parameters reveal that age-related hypertrophy and the gradual loss of cardiac muscle cells take place in both ventricles but have a more dynamic pattern of progression in the left ventricle as compared with the right ventricle.


Circulation ◽  
1982 ◽  
Vol 65 (3) ◽  
pp. 580-590 ◽  
Author(s):  
S C Klausner ◽  
T J Blair ◽  
W F Bulawa ◽  
G M Jeppson ◽  
R L Jensen ◽  
...  

1975 ◽  
Vol 35 (1) ◽  
pp. 134
Author(s):  
James Ehrhardt ◽  
Melvin L. Marcus ◽  
Richard E. Kerber ◽  
Francois M. Abboud

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