scholarly journals Studies on sympathetic nerve, renin-angiotensin and renal kallikrein-kinin systems, and water-sodium balance in essential hypertension.

1980 ◽  
Vol 44 (5) ◽  
pp. 411-421 ◽  
Author(s):  
OSAMU IIMURA ◽  
KENJIRO KIKUCHI ◽  
MIYAMA AKIYOSHI ◽  
TAKASHI NAKAO ◽  
AKIFUMI KONDO ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Sympathetic Nerve ◽  
Sodium Balance ◽  
Renin Angiotensin ◽  
Renal Kallikrein

The Role of Intrarenal Vasoactive Substances in the Pathogenesis of Essential Hypertension

1978 ◽  
Vol 55 (s4) ◽  
pp. 363s-366s ◽  
Author(s):  
K. Abe ◽  
M. Yasujima ◽  
N. Irokawa ◽  
M. Seino ◽  
S. Chiba ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Urinary Excretion ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Prostaglandin E ◽  
Plasma Aldosterone Concentration ◽  
Renin Angiotensin ◽  
Vasoactive Substances ◽  
Angiotensin Ii Antagonist ◽  
Renal Kallikrein

To investigate the role of renal vasoactive substances in the pathogenesis of essential hypertension, urinary prostaglandin E excretion, urinary kallikrein excretion, plasma renin activity, plasma aldosterone concentration and urinary Na excretion were measured in normal subjects and patients with essential hypertension after stimulation of the renin—angiotensin—aldosterone system by the intravenous injection of frusemide or a low Na diet; after the inhibition of renin—angiotensin—aldosterone by an angiotensin II antagonist and after the inhibition of renal prostaglandin E synthesis by indomethacin. The urinary excretions of prostaglandin E and kallikrein, plasma renin activity and plasma aldosterone concentration increased after frusemide administration. The urinary excretion of kallikrein increased after frusemide or a low Na diet but decreased after the angiotensin II antagonist and indomethacin during Na depletion. Changes in urinary kallikrein excretion paralleled those in the renin—angiotensin—aldosterone system after various stimuli. The urinary excretion of prostaglandin E increased after frusemide. However, a dissociation between the urinary excretions of prostaglandin E and kallikrein was found during the low Na diet: the former decreased and the latter increased. The urinary excretion of prostaglandin E was closely related to urinary Na output after various stimuli. Basal levels of urinary prostaglandin E and kallikrein excretion were lower in essential hypertension than in normal subjects. The release of renal prostaglandin E and kallikrein after frusemide was also suppressed in essential hypertension compared with that in normal subjects. The data indicate that renal kallikrein—kinin and renin—angiotensin—aldosterone may interact in a dynamic fashion to maintain blood pressure, that renal prostaglandin E may be involved in renal Na handling and that the suppression of renal kallikrein—kinin and prostaglandin E in essential hypertension may be an etiological factor in essential hypertension.

Atrial natriuretic peptides in essential hypertension: basal plasma levels and relationship to sodium balance

1991 ◽  
Vol 69 (10) ◽  
pp. 1592-1600 ◽  
Author(s):  
G. A. Sagnella ◽  
N. D. Markandu ◽  
M. G. Buckley ◽  
M. A. Miller ◽  
D. R. J. Singer ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Natriuretic Peptides ◽  
Renin Angiotensin System ◽  
Dietary Sodium ◽  
Sodium Balance ◽  
Potential Importance ◽  
Atrial Natriuretic Peptides ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Atrial Natriuretic

The identification of the atrial natriuretic peptides (ANP) as a new hormonal system has provided a new perspective on the mechanisms controlling renal sodium excretion and abnormalities in sodium homeostasis. The present article focuses on the potential importance of ANP (ANF 99–126) in essential hypertension with particular reference to circulating ANP levels and the relationship between the ANP and the renin–angiotensin system in the control of sodium balance and blood pressure. There is now considerable evidence demonstrating that a substantial proportion of patients with essential hypertension have raised circulating ANP levels. Given the known biological actions of ANP, these raised levels point to important compensatory mechanisms. This is further supported by studies during alterations in dietary sodium intake, as sodium restriction highlighted important relationships between ANP and the renin angiotensin system. The potential importance of ANP in essential hypertension is strengthened by recent demonstration of natriuretic and antihypertensive actions associated with small increases in circulating ANP as induced by administration of exogenous ANP. Furthermore, the recent development of orally active inhibitors of ANP metabolism now provides a basis to determine the therapeutic importance of specific manipulation of endogenous ANP levels in patients with essential hypertension.Key words: ANF, essential hypertension, sodium balance.

scholarly journals Sympathetic nerve activity, plasma renin activity and water-sodium balance in obese patients with essential hypertension.

1986 ◽  
Vol 50 (11) ◽  
pp. 1155-1157 ◽  
Author(s):  
Izumi YAMAJI ◽  
Kenjiro KIKUCHI ◽  
Shingo SHIBATA ◽  
Mitsuhiro NISHIMURA ◽  
Kanae AOKI ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Sodium Balance ◽  
Obese Patients ◽  
Nerve Activity

scholarly journals TOTAL BODY POTASSIUM IN LOW RENIN ESSENTIAL HYPERTENSION WITH REFERENCE TO THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

1978 ◽  
Vol 67 (12) ◽  
pp. 1522-1528
Author(s):  
Shin SUZUKI ◽  
Yutaka DOI ◽  
Shunsuke TASAKI ◽  
Wataru AOI ◽  
Morio KURAMOCHI ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Total Body Potassium ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Total Body
Sign in / Sign up

Export Citation Format

Share Document